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1V-LSD Stats & Data

Psychedelic Research-chemical

Valerie

NPS DataHub

MW407.56

FormulaC25H33N3O2

SMILESCCCCC(=O)n1cc2CC3N(C)CC(C=C3c3cccc1c23)C(=O)N(CC)CC

InChIKeyGIIBVGJWUZNECE-ZZWBGTBQSA-N

2022/5.2 Δ9 10-Ergolene

Chemical Class Lysergamide

Psychoactive Class Psychedelic

Receptor Profile

Receptor Actions

Agonists

5-HT2A receptor partial agonist (weak)

Other

prodrug for LSD via deacylation of valeroyl group

History & Culture

1V-LSD emerged on the online research chemical market in June or July of 2021. Its appearance coincided with the announcement of new German scheduling controls targeting 1cP-LSD under the Neue-psychoaktive-Stoffe-Gesetz (NpSG), suggesting the compound was developed and released specifically as a legal alternative following this regulatory action. The substance quickly gained the informal nickname "Valerie" among users and vendors. The provenance of 1V-LSD remains unknown. Unlike many psychedelics with documented histories stretching back decades, this compound does not appear in any academic literature predating its commercial availability. Its creation appears to have been driven entirely by the grey-market research chemical industry rather than originating from pharmaceutical or academic research. The strategic use of 1-acylated lysergamide derivatives to circumvent controlled substance legislation was apparently anticipated decades before 1V-LSD's emergence. A 1988 DEA report noted the potential for such structural modifications to create legally ambiguous LSD analogues—a prediction that proved prescient with the appearance of compounds like 1V-LSD over thirty years later.

Effect Profile

Curated + 6 Reports

Psychedelic 9.2

Strong visuals, headspace, and auditory effects with moderate body load

Visual Intensity×3

Headspace Depth×3

Auditory Effects×1

Body Load / Somatic Effects×1

Based on reports from:

Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki 1V-LSD

Tolerance & Pharmacokinetics

drugs.wiki

Tolerance Decay

Full tolerance 1h Half tolerance 10d Baseline ~14d

Cross-Tolerances

LSD

90% ●○○

Psilocybin

80% ●○○

Psilocin

80% ●○○

Mescaline

60% ●○○

DMT

80% ●○○

5-MeO-DMT

80% ●○○

2C-B

60% ●○○

2C-E

60% ●○○

Experience Report Analysis

Erowid

6 Reports

2021–2024 Date Range

6 With Age Data

10 Effects Detected

Demographics

Gender Distribution

Age Distribution

Reports Over Time

Effect Analysis

Erowid

Effects aggregated from 6 experience reports (6 Erowid)

6 Reports

10 Effects Detected

6 Positive

2 Adverse

2 Neutral

Effect Sentiment Distribution

Confidence Distribution

Positive Effects 6

Empathy 83.3% 70%

Stimulation 83.3% 70%

Color Enhancement 66.7% 70%

Introspection 66.7% 70%

Focus Enhancement 50.0% 70%

Body High 50.0% 70%

Adverse Effects 2

Muscle Tension 66.7% 70%

Confusion 50.0% 70%

Real-World Dose Distribution

62K Doses

From 9 individual dose entries

Sublingual (n=7)

Median: 0.04mg 25th: 0.04mg 75th: 0.09mg 90th: 0.17mg

mg/kg median: 0.0 mg/kg 75th: 0.001

Form / Preparation

Most common forms and preparations reported

Read full reports on Erowid →

Legal Status

Not scheduled under UN Convention on Psychotropic Substances

Country	Status	Notes
Austria	Legal grey area (NPSG may apply)	Not technically illegal as a specific substance, but may fall under the Neue-Psychoaktive-Substanzen-Gesetz (NPSG) as an analogue of LSD, making it illegal to supply for human consumption.
Canada	Unscheduled	Not a controlled substance under Canadian drug legislation. No specific scheduling exists for this compound.
Germany	Controlled (NpSG)	Controlled under the Neue-psychoaktive-Stoffe-Gesetz (New Psychoactive Substances Act). An initial amendment in September 2022 failed to take effect due to a punctuation error in the legislation. The law was corrected in March 2023, effectively banning 1V-LSD. Production and import with intent to market, administration to another person, and trading are punishable offenses. Possession is illegal but not penalized.
Japan	Controlled	Designated as a controlled substance as of March 20, 2023. Possession, production, and distribution are prohibited under national drug control legislation.
Latvia	Illegal	Although not officially scheduled as a named substance, it is controlled as an LSD structural analogue pursuant to an amendment implemented on June 1, 2015.
South Korea	Temporarily controlled	Placed under legal control in July 2022 on a temporary but renewable basis under the national drug scheduling system.
Sweden	Under investigation	Has been under investigation by Swedish authorities since March 2, 2022 for potential scheduling. May become a controlled substance pending review outcome.
Switzerland	Controlled (Verzeichnis E)	Considered a controlled substance as a defined derivative of lysergic acid under Verzeichnis E, point 263 of the Swiss narcotics scheduling. Permitted when used exclusively for scientific or industrial purposes.
Turkey	Illegal	Classified as a controlled drug substance. Possession, production, supply, and importation are all prohibited under Turkish drug laws.
United Kingdom	Illegal (Psychoactive Substances Act)	Illegal to produce, supply, or import under the Psychoactive Substances Act 2016, which came into effect on May 26, 2016. The Act creates a blanket ban on psychoactive substances intended for human consumption. Personal possession is not criminalized under this Act.
United States	Unscheduled (Analogue Act may apply)	Not specifically scheduled under the Controlled Substances Act. However, since 1V-LSD functions as a prodrug for LSD, its possession and sale may be prosecutable under the Federal Analogue Act when sold or possessed with intent for human consumption.

References

Data Sources

Cited References

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