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    2C-B-FLY molecular structure

    2C-B-FLY Stats & Data

    2c-bromo-fly 2cb-fly 2cbfly
    NPS DataHub
    MW320.61
    FormulaC12H15BrClNO2
    CAS178557-21-6
    IUPAC2-(4-Bromo-2,3,6,7-tetrahydrofuro[2,3-''f''][1]benzofuran-8-yl)ethanamine
    SMILES[Cl-].NCCc1c2CCOc2c(Br)c2CCOc12.[H+]
    InChIKeyXHRNOQRXDGETTA-UHFFFAOYSA-N
    Phenethylamines; 2020/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2021/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2022/1. Von 2-Phenethylamin abgeleitete Verbindungen
    Chemical Class Phenethylamine
    Psychoactive Class Psychedelic
    Half-Life Not well established; clinical PK data lacking. Effects typically last 7–12 h.

    Receptor Profile

    Receptor Actions

    Agonists
    5-HT2A receptor agonist (partial)
    5-HT2B receptor agonist
    5-HT2C receptor agonist
    5-HT1D receptor agonist (unusually high affinity for a 2C compound)

    History & Culture

    1995–present

    2C-B-FLY was first described in the scientific literature in 1995 by Aaron Phillip Monte and David E. Nichols along with colleagues at Purdue University. Monte, a Professor of Chemistry at the University of Wisconsin-La Crosse, synthesized this novel compound as part of research into the phenethylamine class. Following its initial description, Alexander Shulgin subsequently evaluated the compound, contributing to the early characterization of its psychoactive properties.

    2005–2016

    By 2005, 2C-B-FLY had gained sufficient popularity within the research chemical community to warrant its own dedicated Erowid vault. However, its presence in the market was abruptly disrupted in October 2009 when two deaths occurred in Denmark and the United States. These fatalities were initially and erroneously attributed to 2C-B-FLY, but investigation revealed that the substance involved was actually Bromo-DragonFLY, which had been mislabeled as 2C-B-FLY by a small research chemical vendor. This mislabeling proved catastrophic because Bromo-DragonFLY is active in the microgram range while 2C-B-FLY requires milligram doses, resulting in massive overdoses when users took what they believed to be standard 2C-B-FLY doses. The incident led to the immediate withdrawal of 2C-B-FLY from the market for several years. The compound resurfaced in early 2016 when it was released by Lizard Labs, a research chemical supplier. At that time, it represented one of the few functional psychedelic compounds readily and legally available on the open market, at least until the United Kingdom's Psychoactive Substances Act came into effect in May 2016.

    Effect Profile

    Curated + 19 Reports
    Psychedelic 7.0

    Strong visuals, body load, and auditory effects with moderate headspace

    Visual Intensity×3
    10
    Headspace Depth×3
    6
    Auditory Effects×1
    8
    Body Load / Somatic Effects×1
    10
    Empathogen 7.0

    Strong sensory enhancement with moderate euphoria, stimulation, and empathy

    Empathy / Social Openness×3
    6
    Euphoria / Mood Elevation×2
    7
    Stimulation×1
    7
    Sensory Enhancement×1
    10

    Duration Timeline

    Bluelight
    Onset Comeup Peak Offset After Effects
    Oral
    30 minutes - 1.0 hours
    1-2 hours
    3-5 hours
    2-3 hours
    6-24 hours
    Total: 6-12 hours
    Insufflated
    10-19 minutes
    30 minutes - 1.0 hours
    2-4 hours
    1-2 hours
    4-12 hours
    Total: 6-12 hours

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Not well established; clinical PK data lacking. Effects typically last 7–12 h.
    Addiction Potential
    Low; not habit-forming, with little evidence of compulsive use or dependence.

    Tolerance Decay

    Full tolerance 1d Half tolerance 7d Baseline ~14d

    Cross-tolerance with serotonergic psychedelics is expected; anecdotal decay to baseline ~2 weeks. Data quality is limited; space experiences to reduce variability.

    Cross-Tolerances

    LSD
    60% ●○○
    Psilocybin
    60% ●○○
    2C-B
    70% ●○○

    Experience Report Analysis

    Erowid
    19 Reports
    2005–2023 Date Range
    11 With Age Data
    22 Effects Detected

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Effect Analysis

    Erowid

    Effects aggregated from 19 experience reports (19 Erowid)

    19 Reports
    22 Effects Detected
    9 Positive
    7 Adverse
    6 Neutral

    Effect Sentiment Distribution

    Confidence Distribution

    Positive Effects 9

    Color Enhancement 78.9% 70%
    Tactile Enhancement 63.2% 70%
    Stimulation 52.6% 70%
    Music Enhancement 52.6% 70%
    Euphoria 47.4% 70%
    Body High 47.4% 70%
    Empathy 36.8% 70%
    Focus Enhancement 31.6% 70%
    Introspection 26.3% 70%

    Adverse Effects 7

    Anxiety 36.8% 70%
    Nausea 36.8% 70%
    Confusion 31.6% 70%
    Headache 26.3% 70%
    Muscle Tension 21.1% 70%
    Sweating 21.1% 70%
    Pupil Dilation 15.8% 70%

    Dosage Distribution

    Dose distribution from experience reports

    Median: 14.0 mg IQR: 10.0–15.0 mg n=11

    Real-World Dose Distribution

    62K Doses

    From 31 individual dose entries

    Oral (n=30)

    Median: 11.0mg 25th: 10.0mg 75th: 15.0mg 90th: 20.0mg
    mg/kg median: 0.155 mg/kg 75th: 0.214

    Form / Preparation

    Most common forms and preparations reported

    Body-Weight Dosing

    Dose relative to body weight from reports with weight data

    Median: 0.152 mg/kg IQR: 0.123–0.215 mg/kg n=11

    Redose Patterns

    Redosing behavior across 13 reports

    23.1% Redosed
    1.3 Avg Doses
    15m Median Interval

    Legal Status

    Country Status Notes
    Austria Illegal (NPSG) Controlled under the Neue-Psychoaktive-Substanzen-Gesetz (New Psychoactive Substances Act). Possession, production, and sale are prohibited.
    Canada Schedule III (CDSA) Classified as a controlled substance under Schedule III of the Controlled Drugs and Substances Act as of October 31, 2016. Scheduled as a derivative of 2,5-dimethoxyphenethylamine.
    Finland Scheduled Listed in the government decree on psychoactive substances banned from the consumer market.
    Germany Controlled (NpSG) Regulated under the Neue-psychoaktive-Stoffe-Gesetz (New Psychoactive Substances Act) since November 26, 2016. Production and importation with intent to distribute, administration to others, and trading are criminally punishable. Possession is prohibited but carries no penalty.
    Italy Schedule I Listed as a Schedule I controlled substance. Possession, production, sale, and purchase are illegal.
    Netherlands Legal (research chemical) Currently available as a research chemical when not sold for human consumption. However, pending legislation on New Psychoactive Substances may result in future scheduling.
    Poland Unscheduled Not explicitly scheduled under Polish drug law. However, as a derivative of 2,5-dimethoxyphenethylamine, it could potentially be classified as a Group II-P substance under analogue provisions.
    Sweden Illegal Controlled substance as of April 2018. Possession, sale, purchase, and use are prohibited under Swedish narcotics legislation.
    Switzerland Ambiguous Legal status remains unclear. The compound's structural classification under Verzeichnis E point 130 is contested, as it does not clearly fit the definition of an alkyl, alkoxy, alkylenedioxy, or halide derivative of phenethylamine due to its fused ring system.
    Turkey Illegal Classified as a controlled drug. Possession, production, supply, and importation are prohibited.
    United Kingdom Illegal (Psychoactive Substances Act) Controlled under the Psychoactive Substances Act 2016, which came into effect on May 26, 2016. Production, supply, and importation are criminal offenses. The compound was legally available on the open market prior to this blanket ban.
    United States Unscheduled Not specifically scheduled or controlled under federal law. However, the Federal Analogue Act may apply if the substance is sold or possessed with intent for human consumption, given its structural and pharmacological similarity to the Schedule I substance 2C-B.

    Harm Reduction

    drugs.wiki

    2C-B-FLY’s oral onset can be slow and variable (20–180+ minutes), so redosing early carries a real overshoot risk; wait at least 3 hours before considering any additional dose. Mislabeling events in 2009 involved Bromo-DragonFLY being sold as 2C-B-FLY; the former is far more potent, longer-lasting, and notably more vasoconstrictive—use reagent tests as a preliminary screen only and prefer GC/MS drug checking when feasible; treat unknown batches with allergy tests (≤1 mg) and conservative titration. Insufflation is commonly reported as extremely painful for 2C-x and specifically for 2C-B-FLY; it tends to shorten duration and roughen the come-up—oral is generally preferred for predictability. As with phenethylamine psychedelics, expect transient increases in heart rate and blood pressure; those with cardiovascular, seizure, or bipolar disorders should avoid or consult a clinician. Salt form affects mass: most references cite the HCl or HBr salts; HBr typically requires roughly 10–20% more mass than HCl for equivalent base—always calculate by salt and weigh accurately. Because of the slow come-up and moderate length, plan set/setting, hydration, and recovery time; avoid combining with stimulants, tramadol, or MAOIs. If effects escalate well past 12 hours with pronounced cold/numb extremities and severe vasoconstriction, suspect misidentification (e.g., Bromo-DragonFLY) and seek medical care; do not redose or take vasoconstrictors. As with all psychedelics, cross-tolerance with other 5-HT2A agonists occurs for several days; spacing experiences by 2+ weeks helps restore baseline sensitivity and reduces compulsive redosing pressure.

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