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    2C-G molecular structure

    2C-G Stats & Data

    2cg
    NPS DataHub
    MW209.29
    FormulaC12H19NO2
    CAS207740-18-9
    IUPAC3,4-Dimethyl-2,5-dimethoxyphenethylamine
    SMILESNCCc1cc(OC)c(C)c(C)c1OC
    InChIKeyNFOHGLKGLZIHJQ-UHFFFAOYSA-N
    Phenethylamines; 2020/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2021/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2022/1. Von 2-Phenethylamin abgeleitete Verbindungen
    Chemical Class Phenethylamine
    Psychoactive Class Psychedelic
    Half-Life Unknown; no human PK published. Long effect window (18–30 h) suggests slow elimination and/or active metabolites.

    Pharmacology

    DrugBank

    Description

    In Shulgin's book PiHKAL, the dosage range is listed as 20 to 35 mg. Effects are similar to the related Ganesha, and are extremely long lasting; the duration is 18–30 hours. Visual effects are muted or absent, and it is described in PiHKAL as an "insight-enhancer". Unlike other members of the 2C family, 2C-G is nearly as potent as its amphetamine cousin.

    Receptor Profile

    Receptor Actions

    Agonists
    5-HT2A receptor agonist (partial)
    5-HT2B receptor agonist (partial)
    5-HT2C receptor agonist (partial)

    History & Culture

    2C-G was first synthesized by Alexander Shulgin and initially described in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved). The compound, also designated as 2C-G-0 or 3-methyl-2C-D, shares structural and pharmacodynamic characteristics with both 2C-D and its corresponding amphetamine analog, Ganesha. Shulgin's research established the foundation for what became known as the 2C-G series, which encompasses several related homologues. In his documentation, Shulgin classified 2C-G as a genuine psychedelic with notable insight-enhancing properties, though he observed that its remarkably extended duration made it impractical for therapeutic applications. He noted an unusual convergence in potency between 2C-G and its amphetamine counterpart Ganesha, whereas phenethylamines are typically somewhat less potent than their corresponding amphetamine analogs. The substance has remained extremely rare within the broader landscape of 2C-family compounds.

    Effect Profile

    Curated
    Psychedelic 7.2

    Strong visuals with moderate headspace, mild auditory effects and body load

    Visual Intensity×3
    10
    Headspace Depth×3
    6
    Auditory Effects×1
    4
    Body Load / Somatic Effects×1
    4

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Unknown; no human PK published. Long effect window (18–30 h) suggests slow elimination and/or active metabolites.
    Addiction Potential
    Low; not considered habit-forming. Long duration and slow onset make frequent use impractical and discourage compulsive redosing.

    Tolerance Decay

    Full tolerance 1d Half tolerance 7d Baseline ~14d

    Pattern extrapolated from community reports on 2C-x and general psychedelic tolerance models (5-HT2A downregulation). Expect markedly diminished effects for several days, with near-baseline by 2–4 weeks. Data quality is low; individual variability is large.

    Cross-Tolerances

    Other psychedelics (phenethylamines and tryptamines)
    50% ●○○

    Legal Status

    Country Status Notes
    Canada Schedule III Classified as a controlled substance under Schedule III as of October 31, 2016.
    United Kingdom Class A Controlled as a Class A substance along with all other compounds featured in PiHKAL. Class A drugs carry the most severe penalties under the Misuse of Drugs Act 1971.
    United States Schedule I Controlled as a Schedule I substance due to its classification as a positional isomer of 2C-E and DOM under the Controlled Substances Act.

    Harm Reduction

    drugs.wiki

    • Active oral range is reported as 20–35 mg with 18–30 h duration in the original PiHKAL entry; this unusually long span increases risks of fatigue, sleep loss, and decision-making lapses late in the experience, so plan a 36–48 h recovery window and avoid redosing. • Onset can be slow; some G-series compounds reach full intensity 2–3 h after dosing. Redosing before 3 h risks accidental over-intoxication. • Users and Shulgin’s own notes describe relatively mild visual phenomena and a clearer, more stimulating headspace compared to other 2C-x, with occasional appetite suppression; stimulation without strong visuals can still produce anxiety, tachycardia, and vasoconstriction. • Because the active range is low tens of milligrams, accurate weighing is essential; use a calibrated 0.001 g scale or volumetric dosing to prevent dangerous overshoot. • Avoid insufflation: other 2C-x phenethylamines cause severe nasal irritation and unpredictable potency when snorted; oral is the established route for 2C-G. • Do not combine with MAOIs (including harmala alkaloids); MAO inhibition can markedly and unpredictably potentiate psychedelics. • Combining with other stimulants (including high caffeine doses) increases cardiovascular strain and anxiety; keep caffeine typical dietary or lower, and avoid amphetamines. • If an experience becomes overwhelming, non-pharmacological de-escalation (reassurance, quiet space, hydration) is first-line; in a true crisis, benzodiazepines can be used by a sober sitter or medical professional, but repeated benzo use carries tolerance and dependence risks and should not be routine. • 2C-G has been scarce; recent market appearances have included inconsistent labeling and premixed capsules that prevent accurate dose control. Use a lab-based drug checking service when possible; reagent results for 2C-G are not well characterized. • People with cardiovascular disease, uncontrolled hypertension, severe anxiety, or sleep disorders should avoid 2C-G due to its long stimulation window and potential for insomnia. • Legal status varies; synthesis, possession, or distribution may be illegal in many jurisdictions.

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