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    3-CPM molecular structure

    3-CPM Stats & Data

    Pal-594 3-cl-pm 3c-phenmetrazine
    NPS DataHub
    MW248.15
    FormulaC11H15Cl2NO
    CAS2903889-68-7
    IUPAC2-(3-Chlorophenyl)-3-methylmorpholine hydrochloride
    SMILES[Cl-].CC1NCCOC1c1cccc(Cl)c1.[H+]
    InChIKeyVZCXTEIFMRHIQB-UHFFFAOYSA-N
    Phenylmorpholines
    Chemical Class Amphetamine
    Psychoactive Class Stimulant
    Half-Life Unknown in humans (no formal PK studies identified).

    Effect Profile

    Curated
    Stimulant 5.4

    Strong anxiety/jitters with moderate euphoria and focus, mild stimulation

    Stimulation / Energy×3
    5
    Euphoria / Mood Lift×2
    7
    Focus / Productivity×2
    7
    Anxiety / Jitters×1
    10

    Tolerance & Pharmacokinetics

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    Half-Life
    Unknown in humans (no formal PK studies identified).
    Addiction Potential
    Moderate to high: multiple reports describe compulsive redosing, especially with intranasal or vaporized use, similar to other short-acting stimulants.

    Tolerance Decay

    Full tolerance 3d Half tolerance 7d Baseline ~30d

    Patterns are extrapolated from community reports for 3‑CPM and closely related phenylmorpholines (e.g., 3‑FPM). Tolerance seems to build rapidly over consecutive days, with partial reversal over 1–2 weeks and near-baseline after a month or more. Data quality is low/anecdotal.

    Cross-Tolerances

    Amphetamines
    50% ●○○
    Cathinones
    40% ●○○
    Other phenylmorpholines (e.g., 3‑FPM)
    60% ●○○

    Harm Reduction

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    - Identity: 3-CPM is a phenylmorpholine stimulant closely related to phenmetrazine and 3‑FPM; it has no established human pharmacokinetics, so interindividual variability and supply purity are major risks. Use small allergy tests and a calibrated milligram scale.

    - Potency/compulsion: Users frequently report a strong urge to redose, especially via intranasal or vaporized routes. Planning dose limits and spacing sessions reduces binge risk and residual insomnia.

    - Cardiovascular strain: Like other stimulants, it can raise heart rate and blood pressure and cause vasoconstriction; people with cardiovascular disease, hypertension, or risk factors should avoid it. Seek medical care for chest pain, severe headache, or persistent tachycardia.

    - Nasal harm: Intranasal use is often described as extremely caustic with burning pain lasting 20–40 minutes; repeated lines increase epistaxis and septal damage risk. If choosing to snort, finely pulverize, use personal sterile straws, pre/post-rinse with isotonic saline, rotate nostrils, and take long breaks.

    - Pulmonary irritation: Vaporizing/smoking has been reported to cause harsh throat/lung irritation; unknown pyrolysis products may add risk. Avoid high-temperature hits and large boluses; oral ROA is safer for tissues.

    - Sleep/comedown: Residual stimulation commonly impairs sleep. Avoid late-day dosing; plan 24 h of recovery time, nutrition, and sleep hygiene.

    - Hydration/temperature: Stimulants increase core temperature and sweat. Sip ~250 mL water/hour at rest (up to 500 mL/hour if active) with electrolytes; take cooling breaks, and avoid hot environments.

    - Serotonergic combinations: Combining with MDMA, tramadol, or serotonergic antidepressants increases serotonin-toxicity risk (agitation, clonus, hyperthermia); avoid.

    - Seizure threshold: Tramadol and stimulant co-use raises seizure risk; avoid this combination.

    - Testing/purity: Reagents may not distinguish phenylmorpholine analogs; where available, use lab-based drug checking or spectrometric services. Avoid unknown vendors.

    - Drug testing: Phenmetrazine analogs may trigger amphetamine-class immunoassay positives; confirmatory testing distinguishes them but is not routine.

    - Storage: Keep powders in airtight, dry, dark containers; minimize oxygen and heat exposure. Let sealed containers warm to room temperature before opening to prevent condensation.

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