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    4-FMA molecular structure

    4-FMA Stats & Data

    4-fluromethamphetamine 4fma
    NPS DataHub
    MW167.23
    FormulaC10H14FN
    CAS351-03-1
    IUPAC1-(4-fluorophenyl)-N-methylpropan-2-amine
    SMILESCNC(C)Cc1ccc(F)cc1
    InChIKeyYCWZPIHKUYZTFM-UHFFFAOYSA-N
    Phenethylamines; 2020/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2021/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2022/1. Von 2-Phenethylamin abgeleitete Verbindungen
    Chemical Class Amphetamine
    Psychoactive Class Psychedelic / Stimulant

    Receptor Profile

    Receptor Actions

    Inhibitors
    Serotonin reuptake inhibitor
    Dopamine reuptake inhibitor
    Norepinephrine reuptake inhibitor
    CYP450 inhibitor
    Other
    Serotonin releasing agent
    Dopamine releasing agent
    Norepinephrine releasing agent

    History & Culture

    4-Fluoromethamphetamine first emerged in documented form when it was detected in legal high products sold in Japanese markets in 2006. Japan subsequently moved to regulate the compound in 2008, prohibiting its sale and possession with intent to distribute while stopping short of criminalizing simple possession for personal use. The substance entered the online research chemical market where it was sold alongside other fluorinated amphetamine analogues including 2-FA, 3-FA, and 4-FA. 4-FMA remained relatively obscure compared to its more popular cousin 4-FA until regulatory changes triggered a significant market shift. When 4-FA was made illegal in the Netherlands in 2017, 4-FMA gained popularity as a legal substitute due to their similar names and effects. By 2018, this transition became apparent in analyzed samples, with products purported to contain 4-FA increasingly found to contain 4-FMA and other fluorinated amphetamines instead. The availability of genuine 4-FA decreased sharply during this period, cementing 4-FMA's position as one of the more widely available fluorinated amphetamines in the research chemical market.

    Effect Profile

    Curated + 2 Reports
    Psychedelic 0.6

    Strong body load with low headspace

    Visual Intensity×3
    0
    Headspace Depth×3
    1
    Auditory Effects×1
    0
    Body Load / Somatic Effects×1
    8
    Empathogen 6.1

    Strong euphoria with moderate stimulation, mild empathy, low sensory enhancement

    Empathy / Social Openness×3
    5
    Euphoria / Mood Elevation×2
    10
    Stimulation×1
    7
    Sensory Enhancement×1
    1
    Stimulant 5.9

    Strong euphoria and anxiety/jitters with moderate focus, mild stimulation

    Stimulation / Energy×3
    5
    Euphoria / Mood Lift×2
    10
    Focus / Productivity×2
    6
    Anxiety / Jitters×1
    10

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 1d Half tolerance 12d Baseline ~21d

    Cross-Tolerances

    Amphetamine
    75% ●○○
    Methamphetamine
    75% ●○○
    Lisdexamfetamine
    75% ●○○
    2-FA
    75% ●○○
    2-FMA
    75% ●○○
    3-FA
    75% ●○○
    4-FA
    40% ●○○
    Methylphenidate
    75% ●○○

    Experience Report Analysis

    Erowid
    2 Reports
    2011–2012 Date Range
    2 With Age Data

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Legal Status

    Country Status Notes
    Australia Schedule 9 Prohibited substance under the Poisons Standard. Defined as a substance which may be abused or misused, where manufacture, possession, sale or use should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of health authorities.
    Austria Illegal (NPSG) Controlled under the Neue-Psychoaktive-Substanzen-Gesetz (New Psychoactive Substances Act). Possession, production, and sale are prohibited.
    Canada Schedule I (analogue) Controlled since 1996 as an analogue of methamphetamine. Falls under the Controlled Drugs and Substances Act with associated criminal penalties for possession, trafficking, and production.
    China Controlled substance Designated a controlled substance as of October 2015 under national drug control legislation.
    Finland Scheduled (narcotic) Listed in the government decree on narcotic substances, preparations and plants. Possession and distribution are illegal under Finnish narcotics law.
    France Not explicitly scheduled As of December 2024, not specifically listed in controlled substance schedules. Exists in a legal grey area where possession may be permitted but regulatory status remains ambiguous.
    Germany Anlage II BtMG Controlled under Schedule II of the Betäubungsmittelgesetz (Narcotics Act) since July 26, 2012. Manufacturing, possession, import, export, purchase, sale, procurement, and dispensing without license are prohibited.
    Italy Schedule I Listed as a Schedule I controlled substance under Italian drug legislation. Production, sale, and possession are prohibited.
    Japan Controlled substance First detected in legal highs sold in 2006. Since 2008, illegal to sell or possess with intent to distribute, though simple possession for personal use is not criminalized.
    New Zealand Schedule 3 (Class C) Controlled as an amphetamine analogue under the Misuse of Drugs Act. Schedule 3 substances carry penalties for possession, supply, and manufacture.
    Switzerland Controlled (Verzeichnis E) Specifically named as a controlled substance under Verzeichnis E of the Swiss narcotics regulations. Unauthorized handling is prohibited.
    United Kingdom Class A Controlled under the Misuse of Drugs Act 1971, added through the 1977 amendment covering fluorinated amphetamine derivatives. Class A designation carries the most severe penalties including up to 7 years imprisonment for possession.
    United States Unscheduled (Analogue Act applies) Not specifically scheduled at the federal level. However, as a structural analogue of methamphetamine, sale or possession could be prosecuted under the Federal Analogue Act when intended for human consumption.
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