4C-D
Aliases: 4c-dom, Ariadne, Bl-3912, Ξ-et-2c-d, Dimoxamine
Categories
Summary
4C-D (Ariadne) is a rare psychedelic phenethylamine first synthesized by Alexander Shulgin in 1968. It was developed by Bristol Laboratories and reached phase 3 clinical trials as an antidepressant and motivational enhancer before being discontinued for economic reasons. Unlike typical psychedelics, 4C-D produces minimal hallucinogenic effects even at high doses, instead causing mental alertness, mood enhancement, and mild stimulation. Shulgin described it as producing 'the alert of a psychedelic, with none of the rest of the package.' Clinical trials suggested efficacy for depression, Parkinson's disease symptoms, and cognitive enhancement in elderly patients. Very limited human data exists beyond Shulgin's testing and unpublished clinical trials.
Perspectives
“I believe that my mood has distinctly improved, and my sleep that evening was excellent. This is physically benign.”
Dose Information
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 20-60 min | 30-60 min | 1-3 hrs | 2-4 hrs | 6 hrs |
Tolerance
Effects
- Stimulation
- Increased heart rate
- Teeth grinding
- Pupil dilation
- Vasoconstriction
- Insomnia
- Increased perspiration
- Sweating
- Nausea
- Decreased appetite
- Motivation enhancement
- Wakefulness
- Analysis enhancement
- Cognitive euphoria
- Emotion enhancement
- Empathy enhancement
- Sociability enhancement
- Euphoria
- Anxiety
- Thought acceleration
- Color enhancement
- Pattern recognition enhancement
- Acuity enhancement
- Tactile enhancement
- Increased music appreciation
- Increased libido
- Light sensitivity
- Dehydration
- Appetite suppression
- Disinhibition
Combinations
PiHKAL / TiHKAL
“I believe that my mood has distinctly improved, and my sleep that evening was excellent. This is physically benign.”