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    AB-FUBINACA molecular structure

    AB-FUBINACA Stats & Data

    Ab-fub Ab-fubi
    NPS DataHub
    MW368.41
    FormulaC20H21FN4O2
    CAS1629062-56-1
    IUPACN-[(2R)-1-amino-3-methyl-1-oxobutan-2-yl]-1-[(4-fluorophenyl)methyl]indazole-3-carboxamide
    SMILESFc1ccc(cc1)Cn1nc(C(=O)NC(C(C)C)C(O)=N)c2ccccc12
    InChIKeyAKOOIMKXADOPDA-QGZVFWFLSA-N
    Cannabinoids; 2020/2.1 Von Indol Pyrazol und 4-Chinolon abgeleitete Verbindungen; 2021/2.1 Von Indol Pyrazol und 4-Chinolon abgeleitete Verbindungen; 2022/2.1 Von Indol Pyrazol und 4-Chinolon abgeleitete Verbindungen
    Chemical Class Cannabinoid

    Receptor Profile

    Receptor Actions

    Agonists
    CB1 receptor agonist (full, Ki 0.9 nM, EC50 1.8 nM)
    CB2 receptor agonist (full, Ki 23.2 nM, EC50 3.2 nM) with some selectivity for CB2

    History & Culture

    AB-FUBINACA was initially synthesized by Pfizer in 2009 during research into novel analgesic compounds. The pharmaceutical company never advanced the substance to human clinical trials, and it was subsequently abandoned as a potential medication. The compound first appeared on the recreational drug market in 2012, when Japanese researchers identified it as an active ingredient in synthetic cannabinoid products being sold in that country. It was discovered alongside AB-PINACA, a structurally related compound that had not been previously documented in the scientific literature. AB-FUBINACA subsequently became one of the more prevalent synthetic cannabinoids circulating in recreational drug markets. In August 2018, AB-FUBINACA gained significant public attention following a mass overdose event in New Haven, Connecticut. Beginning on August 15, approximately 70 individuals overdosed in the vicinity of Yale University's campus after consuming adulterated synthetic cannabis products. By the end of that week, over 100 people had required emergency medical transport to local hospitals. Law enforcement subsequently arrested three individuals on charges related to dealing synthetic cannabis products containing AB-FUBINACA.

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 3d Half tolerance 21d Baseline ~28d

    Experience Report Analysis

    Erowid
    2 Reports
    2014–2015 Date Range
    2 With Age Data

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Legal Status

    UNODC Schedule II (recommended December 2019)
    Country Status Notes
    China Controlled Classified as a controlled substance since October 2015 under national drug control regulations. Manufacturing, trafficking, and possession are subject to legal penalties.
    Finland Banned Scheduled in a government decree on psychoactive substances prohibited from the consumer market, effective 19 October 2017. Production, import, sale, and possession for sale are prohibited.
    Germany Anlage II BtMG Listed as an Anlage II controlled substance under the Betäubungsmittelgesetz since November 2014. This classification permits restricted medical and scientific use under license.
    United States Schedule I Designated as a Schedule I controlled substance in January 2014. Classified as having high abuse potential with no accepted medical use under the Controlled Substances Act.
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