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    Benzodiazepines can cause physical dependence with regular use. Withdrawal can be life-threatening. Never combine with opioids or alcohol.

    Acetazolamide

    Summary

    Acetazolamide is a depressant benzodiazepine. Reported effects include euphoria, anxiety suppression, muscle relaxation, and compulsive redosing. Limited data is available on its dosage and safety profile.

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Benzodiazepine 7.6
    Intense 8/10

    Strong anxiolysis and euphoria with moderate cognitive impairment, mild sedation

    Anxiolysis ×3
    10
    anxiety suppression anxiolytic reduced anxiety muscle relaxation
    Sedation / Relaxation ×2
    5
    sedation muscle relaxation
    Motor / Cognitive Impairment ×1
    7
    motor control loss amnesia double vision
    Euphoria / Mood Lift ×1
    10
    cognitive euphoria euphoria physical euphoria disinhibition

    Tolerance

    Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
    Reset weeks to months depending on half-life and duration of use; taper recommended

    Tolerance Decay

    Full tolerance 3d Half tolerance 37d Baseline ~60d

    Effects

    Positive
    • Muscle relaxation
    • Physical euphoria
    • Anxiolytic
    Negative
    • Motor impairment
    • Respiratory depression
    • Nausea
    Neutral
    • Sedation
    • Itchiness
    • Sedative
    • Dystaxia
    Positive
    • Reduced anxiety
    • Anxiety suppression
    • Cognitive euphoria
    • Euphoria
    Negative
    • Amnesia
    • Dizziness
    • Motor control loss
    • Thought deceleration
    • Compulsive redosing
    • Constipation
    Positive
    • Increased music appreciation
    • Increased libido
    Negative
    • Disinhibition
    • Appetite suppression
    • Double vision
    • Dehydration
    • Light sensitivity
    Neutral
    • Dulled perception
    • Internal hallucination
    • Internal hallucinations

    Combinations TripSit

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