Acetorphine
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 2 corroborating sources
- 19 combo interactions documented
- classified Research-chemical
- 2 corroborating sources
- 19 combo interactions documented
- classified Research-chemical
Aliases: Acetyletorphine
Summary
Acetorphine (Acetyletorphine) is a synthetic opioid analgesic and a derivative of etorphine. It is extremely potent, reported as up to 8700 times stronger than morphine by weight. It was developed in 1966 by the Reckitt research group exclusively for veterinary immobilization of large animals such as elephants, giraffes, and rhinoceros. Despite showing some advantages over etorphine (reduced toxic side effects in giraffes), it was never widely adopted for veterinary use.
Dose Information
| ROA | Threshold |
|---|---|
| Intramuscular | Not established for humans |
Only a threshold dose is documented for this substance — the smallest amount with a noticeable effect. There is no published light/common/strong ladder to show above it.
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria and pain relief with moderate itching/nausea and sedation
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The PsychonautWiki Journal logging app doesn't include every substance. To track Acetorphine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Acetorphine Source: SubstanceSearch (substancesearch.com) Intramuscular dose: threshold Not established for humans Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Pattern inferred from general opioid pharmacology: tolerance can develop rapidly with repeated daily exposure and may take weeks to return toward baseline once abstinent; cross‑tolerance across mu‑agonists is expected. Data quality is low because acetorphine lacks human studies.
Cross-Tolerances
Effects
- Analgesia
- Physical euphoria
- Muscle relaxation
- Pain relief
- Respiratory depression
- Nausea
- Dry Mouth
- Sedation
- Itchiness
- Relaxant
- Euphoria
- Anxiety suppression
- Reduced anxiety
- Cognitive euphoria
- Mood lift
- Dream potentiation
- Constipation
- Compulsive redosing
- Thought deceleration
- Dizziness
- Appetite suppression
- Double vision
- Decreased libido
- Orgasm suppression
- Cognitive dysphoria
- Dulled perception
- Internal hallucination
- Internal hallucinations
Combinations
Cross-Check Acetorphine with another substanceHelpful Links
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