Acetorphine - Substance Search

Summary TheDrug.Wiki

Acetorphine is an extremely potent synthetic opioid analgesic, up to 8700 times stronger than morphine by weight. It is a derivative of etorphine and was developed in 1966 by the Reckitt research group exclusively for veterinary immobilization of large animals such as elephants, giraffes, and rhinoceros. Despite showing some advantages over etorphine (reduced toxic side effects in giraffes), it was never widely adopted for veterinary use.

Dose Information TheDrug.Wiki

Light Common Strong Heavy

Effect Profile

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Opioid 7.9

Intense 8/10

Strong euphoria and pain relief with moderate itching/nausea and sedation

Euphoria / Warmth ×3

10

physical euphoria euphoria cognitive euphoria mood lift

Analgesia ×2

8

analgesia pain relief

Sedation / Relaxation ×1

6

sedation muscle relaxation dream potentiation

⚠ Itching / Nausea ×1

7

nausea constipation dry mouth

Based on reports from:

Erowid Experience Reports PsychonautWiki Acetorphine

Tolerance

Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance

Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

Tolerance Decay

Full tolerance 3d Half tolerance 7d Baseline ~21d

Pattern inferred from general opioid pharmacology: tolerance can develop rapidly with repeated daily exposure and may take weeks to return toward baseline once abstinent; cross‑tolerance across mu‑agonists is expected. Data quality is low because acetorphine lacks human studies.