Acetorphine Limited data

Limited data

Sparse data. Doses and effects may be unreliable or untested.

2 corroborating sources

29 combo interactions documented

classified Research-chemical

Aliases: Acetyletorphine

Summary dose.wiki

Acetorphine (Acetyletorphine) is a synthetic opioid analgesic and a derivative of etorphine. It is extremely potent, reported as up to 8700 times stronger than morphine by weight. It was developed in 1966 by the Reckitt research group exclusively for veterinary immobilization of large animals such as elephants, giraffes, and rhinoceros. Despite showing some advantages over etorphine (reduced toxic side effects in giraffes), it was never widely adopted for veterinary use.

Dose Information source not identified

ROA	Threshold
Intramuscular	Not established for humans

Only a threshold dose is documented for this substance — the smallest amount with a noticeable effect. There is no published light/common/strong ladder to show above it.

Sources· no ladder identified

Intramuscular

Dose ladder — source not identified

Effect Profile

Scores (0–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Opioid 7.9

Intense 8/10

Strong euphoria and pain relief with moderate itching/nausea and sedation

Euphoria / Warmth ×3

physical euphoria euphoria cognitive euphoria mood lift

Analgesia ×2

analgesia pain relief

Sedation / Relaxation ×1

sedation muscle relaxation dream potentiation

⚠ Itching / Nausea ×1

nausea constipation dry mouth

Tolerance

Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance

Reset Falls quickly once you stop, at a rate you can't judge. After any break, treat your tolerance as gone.

No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.

Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.

Sources: FRANK: heroin · National Harm Reduction Coalition · WHO: opioid overdose · Merrall et al. 2010 · Binswanger et al. 2007 · Strang et al. 2003 · FDA 2019: gabapentinoids and breathing

Cross-Tolerances

Other mu‑opioid agonists (e.g., morphine, fentanyl, etorphine)

Effects dose.wiki

Positive

Negative

Neutral

Positive

Negative

Neutral

Combinations

Cross-Check Acetorphine with another substance

Acetorphine's nerd page Pharmacology, chemical data, effect profiles, and more

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Helpful Links

📖 dose.wiki

Add to PsychonautWiki Journal

The PsychonautWiki Journal logging app doesn't include every substance. To track Acetorphine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

Name

Acetorphine

Unit

Description

Acetorphine
Source: SubstanceSearch (substancesearch.com)

Intramuscular dose: threshold Not established for humans

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

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Acetorphine Limited data Limited data Sparse data. Doses and effects may be unreliable or untested. 2 corroborating sources 29 combo interactions documented classified Research-chemical