Summary
Acetorphine is an extremely potent synthetic opioid analgesic, up to 8700 times stronger than morphine by weight. It is a derivative of etorphine and was developed in 1966 by the Reckitt research group exclusively for veterinary immobilization of large animals such as elephants, giraffes, and rhinoceros. Despite showing some advantages over etorphine (reduced toxic side effects in giraffes), it was never widely adopted for veterinary use. Acetorphine is Schedule I in the United States and Class A in the UK, prohibited for human use. Human exposure can be fatal even at extremely low doses due to severe respiratory depression.
Dose Information
Light
Common
Strong
Heavy
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Effects
Positive
- Analgesia
- Physical euphoria
- Muscle relaxation
- Pain relief
Negative
- Respiratory depression
- Nausea
- Dry Mouth
- Sedation
- Itchiness
- Relaxant
Positive
- Euphoria
- Anxiety suppression
- Reduced anxiety
- Cognitive euphoria
- Mood lift
- Dream potentiation
Negative
- Constipation
- Compulsive redosing
- Thought deceleration
- Dizziness
Positive
Negative
- Appetite suppression
- Double vision
- Decreased libido
- Decreased Libido
- Appetite Suppression
- Orgasm suppression
- Cognitive dysphoria
- Dulled perception
- Internal hallucination
- Internal hallucinations