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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    Acetorphine Limited data
    Limited data
    Sparse data. Doses and effects may be unreliable or untested.
    • 2 corroborating sources
    • 19 combo interactions documented
    • classified Research-chemical

    Aliases: Acetyletorphine

    Depressant Research-chemical Opioid

    Summary TheDrug.Wiki

    Acetorphine (Acetyletorphine) is a synthetic opioid analgesic and a derivative of etorphine. It is extremely potent, reported as up to 8700 times stronger than morphine by weight. It was developed in 1966 by the Reckitt research group exclusively for veterinary immobilization of large animals such as elephants, giraffes, and rhinoceros. Despite showing some advantages over etorphine (reduced toxic side effects in giraffes), it was never widely adopted for veterinary use.

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 7.9
    Intense 8/10

    Strong euphoria and pain relief with moderate itching/nausea and sedation

    Euphoria / Warmth ×3
    10
    physical euphoria euphoria cognitive euphoria mood lift
    Analgesia ×2
    8
    analgesia pain relief
    Sedation / Relaxation ×1
    6
    sedation muscle relaxation dream potentiation
    ⚠ Itching / Nausea ×1
    7
    nausea constipation dry mouth
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Acetorphine
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 3d Half tolerance 7d Baseline ~35d

    Pattern inferred from general opioid pharmacology: tolerance can develop rapidly with repeated daily exposure and may take weeks to return toward baseline once abstinent; cross‑tolerance across mu‑agonists is expected. Data quality is low because acetorphine lacks human studies.

    Cross-Tolerances

    Other mu‑opioid agonists (e.g., morphine, fentanyl, etorphine)
    100%

    Effects TheDrug.Wiki

    Positive
    • Analgesia
    • Physical euphoria
    • Muscle relaxation
    • Pain relief
    Negative
    • Respiratory depression
    • Nausea
    • Dry Mouth
    Neutral
    • Sedation
    • Itchiness
    • Relaxant
    Positive
    • Euphoria
    • Anxiety suppression
    • Reduced anxiety
    • Cognitive euphoria
    • Mood lift
    • Dream potentiation
    Negative
    • Constipation
    • Compulsive redosing
    • Thought deceleration
    • Dizziness
    Negative
    • Appetite suppression
    • Double vision
    • Decreased libido
    • Decreased Libido
    • Appetite Suppression
    • Orgasm suppression
    • Cognitive dysphoria
    Neutral
    • Dulled perception
    • Internal hallucination
    • Internal hallucinations

    Combinations TripSit

    Cross-Check Acetorphine with another substance

    Acetorphine's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki