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    ⚠ Benzodiazepines can cause physical dependence with regular use. Withdrawal can be life-threatening. Never combine with opioids or alcohol.

    Adinazolam

    Aliases: Deracyn, U-41,123, Adinazolamum

    Depressant Benzodiazepine

    Summary TheDrug.Wiki TripSit

    Adinazolam is a short-acting triazolobenzodiazepine originally investigated as both an anxiolytic and antidepressant but never FDA approved. In clinical trials (10-90 mg/day) it showed rapid relief of anxiety and modest antidepressant efficacy comparable to tricyclics with fewer anticholinergic effects. Human studies found adinazolam causes the most mental and physical sedation compared to diazepam and lorazepam, along with significant mental unpleasantness.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 5-15mg 15-30mg 30-50mg 50mg+
    Sublingual 5-15mg 15-30mg 30-50mg 50mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Peak Offset After Effects Total
    Oral 10-25 min 1-2 hrs 1.5-3 hrs 4-16 hrs 2.7-5.4 hrs
    Sublingual 10-25 min 1-2 hrs 1.5-3 hrs 4-16 hrs 2.7-5.4 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Benzodiazepine 7.3
    Strong+ 7/10

    Strong anxiolysis, cognitive impairment, and euphoria with moderate sedation

    Anxiolysis ×3
    10
    anxiety suppression anxiolytic muscle relaxation
    Sedation / Relaxation ×2
    6
    sedation muscle relaxation
    ⚠ Motor / Cognitive Impairment ×1
    10
    motor control loss cognitive impairment memory suppression amnesia double vision
    Euphoria / Mood Lift ×1
    9
    physical euphoria disinhibition
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Adinazolam
    View methodology →

    Tolerance

    Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
    Reset weeks to months depending on half-life and duration of use; taper recommended

    Tolerance Decay

    Full tolerance 14d Half tolerance 7d Baseline ~42d

    Benzodiazepine tolerance develops to most effects with repeated use over days–weeks; cross-tolerance exists across the class and with Z-drugs. On discontinuation, tolerance decays slowly over weeks; clinical practice favors long, individualized tapers to minimize withdrawal. Data are derived largely from class-wide evidence and user reports rather than adinazolam-specific trials.

    Cross-Tolerances

    Other benzodiazepines
    80%
    Non-benzodiazepine Z-drugs
    60%
    Barbiturates
    40%
    Other GABA-A positive modulators
    40%

    Effects TheDrug.Wiki

    Positive
    • Muscle Relaxation
    • Physical Euphoria
    • Muscle relaxation
    • Anxiolytic
    • Physical euphoria
    Negative
    • Respiratory Depression
    • Motor impairment
    • Respiratory depression
    Neutral
    • Sedation
    • Sedative
    Positive
    • Anxiety Suppression
    • Anxiety suppression
    Negative
    • Cognitive Impairment
    • Motor Control Loss
    • Memory Suppression
    • Thought Deceleration
    • Motor control loss
    • Amnesia
    • Thought deceleration
    • Dizziness
    Positive
    • Increased libido
    • Appetite enhancement
    Negative
    • Disinhibition
    • Acuity suppression
    • Double vision
    • Decreased Libido
    • Acuity Suppression
    • Visual acuity suppression
    Neutral
    • Dulled perception
    • Perception of bodily heaviness

    Combinations TripSit

    Adinazolam's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

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