Home
    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Synthetic cannabinoids are far more potent and unpredictable than natural cannabis. They lack a ceiling effect and have been linked to seizures, psychosis, and death.

    AKB-57 Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 16 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Apinac

    Depressant Psychedelic Research-chemical Cannabinoid

    Summary dose.wiki

    1. Potency varies widely between batches; always allergy-test with a tiny match-head amount (<0.5 mg). 2.

    Dose Information dose.wiki Drugs.Wiki

    Dose basis. SCRAs can be ultra‑potent and unevenly distributed on plant material (“hot pockets”); accurate mg scales or volumetric dosing are essential. Start far below listed ranges if identity/purity is unverified. User‑report based; not clinically validated. Oral onset is delayed and effects may be longer/stronger; re‑dosing before full onset has caused overdoses with potent SCRAs. Data are extrapolated from similar indazole carboxamides and user reports; not clinically validated. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Smoked 0.5-1.5mg 1.5-3mg 3-5mg 5mg+
    Oral 1-2mg 2-4mg 4-6mg 6mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Peak Offset After Effects Total
    Smoked 0-2 min 5-30 min 30-90 min 4-6 hrs 0.58-2.03 hrs
    Oral 30-90 min 1-2 hrs 30-90 min 4-6 hrs 2-5 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 5.4
    Moderate+ 5/10

    Moderate visuals with mild headspace, auditory effects, and body load

    Visual Intensity ×3
    7
    color enhancement drifting tracers pattern recognition enhancement
    Headspace Depth ×3
    4
    conceptual thinking time distortion confusion
    Auditory Effects ×1
    4
    auditory distortion
    ⚠ Body Load / Somatic Effects ×1
    4
    nausea increased heart rate
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track AKB-57 there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "AKB-57 (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    AKB-57
    Unit
    mg
    Description 
    AKB-57
Source: SubstanceSearch (substancesearch.com)

Smoked dose (mg): threshold 0.5 · light 0.5-1.5 · common 1.5-3 · strong 3-5 · heavy 5+
Oral dose (mg): threshold 0.5 · light 1-2 · common 2-4 · strong 4-6 · heavy 6+

Smoked duration: onset 0-2m · peak 5-30m · offset 0.5-1.5h · total 0.58-2.03h · after-effects 4-6h
Oral duration: onset 0.5-1.5h · peak 1-2h · offset 0.5-1.5h · total 2-5h · after-effects 4-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 2.25 mg (Smoked).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over weeks of regular use via CB1 receptor downregulation
    Reset 2–4 weeks for most users; heavy users may need longer

    Tolerance Decay

    Full tolerance 2d Half tolerance 14d Baseline ~28d

    Rapid tolerance build with frequent SCRA use is widely reported; decay appears to take weeks. Quantitative model is an illustrative approximation synthesized from user reports, not clinical data.

    Cross-Tolerances

    Other synthetic cannabinoids
    70%
    THC
    30%

    Effects dose.wiki

    Positive
    • Stimulation
    Negative
    • Tachycardia then bradycardia
    • Dry mouth
    • Nausea/vomiting
    • Nausea
    • Increased heart rate
    Neutral
    • Potent mental sedation
    • Motor incoordination
    • Red eyes
    • Sedation
    Positive
    • Euphoria
    • Conceptual thinking
    Negative
    • Short-term memory suppression
    • Paranoia/anxiety/panic
    • Afterglow dysphoria or irritability
    • Anxiety
    • Memory suppression
    • Confusion
    Neutral
    • Rapid intoxication
    • Time distortion
    Positive
    • Tracers
    • Color enhancement
    • Tactile enhancement
    • Increased music appreciation
    • Enhanced tactile sensation
    • Pattern recognition enhancement
    Neutral
    • Closed-eye imagery at higher doses
    • Dulled perception
    • Drifting
    • Auditory distortion

    Combinations

    Cross-Check AKB-57 with another substance

    AKB-57's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki