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    ALEPH-2 molecular structure

    ALEPH-2 Stats & Data

    Dot-2 4-ethylthio-2,5-dimethoxyamphetamine dot2 aleph2
    Chemical Class Amphetamine
    Psychoactive Class Psychedelic / Stimulant
    Half-Life Unknown in humans; effects 8–16 h suggest long subjective duration unrelated to elimination kinetics.

    Pharmacology

    DrugBank
    State Solid

    Description

    2,5-Dimethoxy-4-ethylthioamphetamine (ALEPH-2) is a phenylisopropylamine derivative with alleged anxiolytic and hallucinogenic properties.

    Receptor Profile

    Receptor Actions

    Agonists
    5-HT2A receptor agonist (partial)
    5-HT2C receptor agonist (full)
    Inhibitors
    Monoamine oxidase-A inhibitor (weak, IC50 3,200 nM)

    History & Culture

    ALEPH-2 was first introduced to the scientific literature by Alexander Shulgin in 1978 as part of his systematic exploration of phenethylamine derivatives. The compound belongs to the Aleph series, a family of sulfur-substituted psychedelic amphetamines that Shulgin developed and characterized. A more comprehensive account of ALEPH-2's synthesis, dosage, duration, and qualitative effects appeared in Shulgin's 1991 book PiHKAL (Phenethylamines I Have Known and Loved), where it was catalogued as entry #4. Despite this documentation, ALEPH-2 has remained an exceptionally rare compound with very limited human use reported in the decades since its initial characterization.

    Effect Profile

    Curated + 1 Reports
    Psychedelic 4.6

    Moderate visuals with mild auditory effects and body load, low headspace

    Visual Intensity×3
    7
    Headspace Depth×3
    2
    Auditory Effects×1
    4
    Body Load / Somatic Effects×1
    4
    Stimulant 3.4

    Moderate anxiety/jitters with mild focus, low stimulation and euphoria

    Stimulation / Energy×3
    3
    Euphoria / Mood Lift×2
    3
    Focus / Productivity×2
    4
    Anxiety / Jitters×1
    6

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Unknown in humans; effects 8–16 h suggest long subjective duration unrelated to elimination kinetics.
    Addiction Potential
    Low; classical psychedelic profile. Compulsive redosing is uncommon, but slow onset and long duration can encourage risky stacking if onset is misjudged.

    Tolerance Decay

    Full tolerance 0h Half tolerance 3d Baseline ~7d

    As with classical psychedelics, acute tolerance appears after a single robust session and decays over about 1–2 weeks. Exact kinetics for ALEPH‑2 are not characterized; values extrapolated from broader psychedelic literature and user reports. Data quality: anecdotal.

    Cross-Tolerances

    DOx amphetamines
    70% ●○○
    2C‑x phenethylamines
    60% ●○○
    Tryptamine psychedelics (e.g., psilocybin, LSD)
    50% ●○○

    Experience Report Analysis

    Erowid
    1 Reports
    2002–2002 Date Range

    Demographics

    Gender Distribution

    Reports Over Time

    Legal Status

    Country Status Notes
    United States Unscheduled Not classified as a controlled substance at the federal level as of 2011. As an unscheduled compound, possession is not specifically prohibited under the Controlled Substances Act. However, as a structural analogue of controlled phenethylamines, the Federal Analogue Act may potentially apply if the substance is sold or possessed with intent for human consumption.

    Harm Reduction

    drugs.wiki

    Identity and mislabeling: ALEPH‑2 is extremely rare in circulation. Confirm identity with multi‑reagent testing and, ideally, laboratory drug checking (FTIR/GC‑MS) before ingesting; mis-sold DOx/NBOMe/2C‑x has been documented in the wild. Shulgin lists oral activity at approximately 4–8 mg with 8–16 h duration; due to steep, idiosyncratic dose–response, first assays should be conservative (≤2–3 mg) and no redosing for at least 3 h to avoid stacked overduration and overstimulation. Thio‑substituted phenethylamines (e.g., 2C‑T‑2/‑7) have a track record of unpredictable toxicity and wide interindividual sensitivity; avoid insufflation or parenteral routes because of local irritation and greater unpredictability. Cardiovascular load (tachycardia, vasoconstriction, BP elevation) and mydriasis/bruxism are common; those with cardiovascular, seizure, or significant psychiatric histories should avoid or use only with medical clearance. Potential weak reversible MAO‑A inhibition has been reported in vitro for para‑alkylthio amphetamines; combinations with MAOIs or potent serotonergics (e.g., MDMA, high‑dose tryptamines) increase the risk of hypertensive or serotonergic crises. Onset can be slow and deceptive; early redoses frequently overextend duration and intensity. Plan set/setting and recovery (quiet environment, light nutrition, electrolytes, and sleep hygiene) and anticipate insomnia late in the course; do not use alcohol to force sleep. If severe agitation, hyperthermia, chest pain, or continuous vomiting occur, seek urgent medical care and avoid taking additional substances to self‑treat. Because US mail‑in lab testing via DrugsData is on administrative pause (as of April 2025), consider local in‑person services listed via drugchecking community resources.

    References

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