Summary
Amfecloral was marketed in the 1960s-70s as the anorectic Acutran and withdrawn worldwide by 1973. It functions as a prodrug that hydrolyzes to approximately equimolar amounts of dextroamphetamine (and some levoamphetamine) plus chloral hydrate, producing a unique profile with milder stimulation than pure amphetamine but potential next-day grogginess from the sedative component. The chloral metabolite (trichloroethanol) is a GABAergic hypnotic that can potentiate other CNS depressants—exercise caution with alcohol, benzodiazepines, or barbiturates. Historically, it was noted for having "little to no stimulant activity" compared to other amphetamines, likely due to the powerful sedating effects of chloral hydrate. Little modern human data exists; dosage ranges are extrapolated from historic prescribing information (25 mg tablets, 1-3 times daily) and limited user reports.
Dose Information
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 30-90 min | 30-60 min | 1.5-4 hrs | 2-4 hrs | 6-24 hrs | 300-0 min |
Tolerance
Effects
- Stimulation
- Muscle relaxation
- Physical euphoria
- Teeth grinding
- Dry mouth
- Increased heart rate
- Pupil dilation
- Insomnia
- Respiratory depression
- Sedation
- Wakefulness
- Focus enhancement
- Motivation enhancement
- Euphoria
- Decreased anxiety
- Anxiety
- Cognitive fatigue
- Irritability
- Thought acceleration
- Time distortion
- Increased libido
- Appetite suppression
- Light sensitivity
- Disinhibition
- Double vision
- Visual acuity suppression
- Acuity suppression
- Dulled perception
- Internal hallucination
- Internal hallucinations