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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Amfecloral Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 18 combo interactions documented
    • classified Research-chemical

    Aliases: Acutran, Amphecloral

    Stimulant Research-chemical

    Summary TheDrug.Wiki TripSit

    Amfecloral was marketed in the 1960s-70s as the anorectic Acutran and withdrawn worldwide by 1973. It functions as a prodrug that hydrolyzes to approximately equimolar amounts of dextroamphetamine (and some levoamphetamine) plus chloral hydrate, producing a unique profile with milder stimulation than pure amphetamine but potential next-day grogginess from the sedative component. The chloral metabolite (trichloroethanol) is a GABAergic hypnotic that can potentiate other CNS depressants—exercise caution with alcohol, benzodiazepines, or barbiturates.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 10-25mg 25-50mg 50-75mg 75mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Peak Offset After Effects Total
    Oral 30-90 min 1.5-4 hrs 2-4 hrs 6-24 hrs 6-12 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 5.6
    Strong 6/10

    Strong anxiety/jitters with moderate euphoria and focus, mild stimulation

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    7
    physical euphoria euphoria motivation enhancement
    Focus / Productivity ×2
    7
    focus enhancement motivation enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    8
    anxiety teeth grinding increased heart rate
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Amfecloral
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 18d Half tolerance 5d Baseline ~42d

    Tolerance figures are extrapolated from general amphetamine patterns and chloral-hypnotic tolerance (which develops rapidly) rather than direct studies on amfecloral; treat as approximate and conservative. Avoid consecutive-day use; allow multi-day breaks to limit sleep disruption and crash severity.

    Cross-Tolerances

    Amphetamine
    50%
    Methamphetamine
    40%
    Other amphetamine prodrugs (e.g., clobenzorex)
    50%
    Cathinones
    30%
    Other GABAergic hypnotics (chloral/‘Z-drugs’/barbiturates)
    40%

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    • Muscle relaxation
    • Physical euphoria
    Negative
    • Teeth grinding
    • Dry mouth
    • Increased heart rate
    • Pupil dilation
    • Insomnia
    • Respiratory depression
    Neutral
    • Sedation
    Positive
    • Wakefulness
    • Focus enhancement
    • Motivation enhancement
    • Euphoria
    • Decreased anxiety
    Negative
    • Anxiety
    • Cognitive fatigue
    • Irritability
    Neutral
    • Thought acceleration
    • Time distortion
    Positive
    • Increased libido
    Negative
    • Appetite suppression
    • Light sensitivity
    • Disinhibition
    • Double vision
    • Visual acuity suppression
    • Acuity suppression
    Neutral
    • Dulled perception
    • Internal hallucination
    • Internal hallucinations

    Combinations TripSit

    Cross-Check Amfecloral with another substance

    Amfecloral's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

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