Amfecloral
Aliases: Acutran, Amphecloral
Summary
Amfecloral was marketed in the 1960s-70s as the anorectic Acutran and withdrawn worldwide by 1973. It functions as a prodrug that hydrolyzes to approximately equimolar amounts of dextroamphetamine (and some levoamphetamine) plus chloral hydrate, producing a unique profile with milder stimulation than pure amphetamine but potential next-day grogginess from the sedative component. The chloral metabolite (trichloroethanol) is a GABAergic hypnotic that can potentiate other CNS depressants—exercise caution with alcohol, benzodiazepines, or barbiturates.
Dose Information
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 30-90 min | 30-60 min | 1.5-4 hrs | 2-4 hrs | 4.5-10.5 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong anxiety/jitters with moderate euphoria and focus, mild stimulation
Tolerance
Tolerance Decay
Tolerance figures are extrapolated from general amphetamine patterns and chloral-hypnotic tolerance (which develops rapidly) rather than direct studies on amfecloral; treat as approximate and conservative. Avoid consecutive-day use; allow multi-day breaks to limit sleep disruption and crash severity.
Cross-Tolerances
Effects
- Stimulation
- Muscle relaxation
- Physical euphoria
- Teeth grinding
- Dry mouth
- Increased heart rate
- Pupil dilation
- Insomnia
- Respiratory depression
- Sedation
- Wakefulness
- Focus enhancement
- Motivation enhancement
- Euphoria
- Decreased anxiety
- Anxiety
- Cognitive fatigue
- Irritability
- Thought acceleration
- Time distortion
- Increased libido
- Appetite suppression
- Light sensitivity
- Disinhibition
- Double vision
- Visual acuity suppression
- Acuity suppression
- Dulled perception
- Internal hallucination
- Internal hallucinations