Amfecloral
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- classified Research-chemical
Aliases: Acutran, Amphecloral
Summary
Amfecloral was marketed in the 1960s-70s as the anorectic Acutran and withdrawn worldwide by 1973. It functions as a prodrug that hydrolyzes to approximately equimolar amounts of dextroamphetamine (and some levoamphetamine) plus chloral hydrate, producing a unique profile with milder stimulation than pure amphetamine but potential next-day grogginess from the sedative component. The chloral metabolite (trichloroethanol) is a GABAergic hypnotic that can potentiate other CNS depressants—exercise caution with alcohol, benzodiazepines, or barbiturates.
Dose Information
Dose basis. Historic Rx tablets were 25 mg Acutran; contemporary human data are scarce. As a prodrug with slower onset, early redosing can cause delayed stacking; wait at least 2–3 hours before considering more. Doses below are extrapolated from archival prescribing info and anecdotal reports; start at the low end, allergy test 1–2 mg if material identity is uncertain. (Dose figures and this note are from Drugs.Wiki.)
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 10-25mg | 25-50mg | 50-75mg | 75mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 30-90 min | 30-60 min | 1.5-4 hrs | 2-4 hrs | 5-8 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong anxiety/jitters with moderate euphoria and focus, mild stimulation
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The PsychonautWiki Journal logging app doesn't include every substance. To track Amfecloral there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Amfecloral Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 10 · light 10-25 · common 25-50 · strong 50-75 · heavy 75+ Oral duration: onset 0.5-1.5h · come-up 0.5-1h · peak 1.5-4h · offset 2-4h · total 5-8h · after-effects 6-24h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 37.5 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Tolerance figures are extrapolated from general amphetamine patterns and chloral-hypnotic tolerance (which develops rapidly) rather than direct studies on amfecloral; treat as approximate and conservative. Avoid consecutive-day use; allow multi-day breaks to limit sleep disruption and crash severity.
Cross-Tolerances
Effects
- Stimulation
- Muscle relaxation
- Physical euphoria
- Teeth grinding
- Dry mouth
- Increased heart rate
- Pupil dilation
- Insomnia
- Respiratory depression
- Sedation
- Wakefulness
- Focus enhancement
- Motivation enhancement
- Euphoria
- Decreased anxiety
- Anxiety
- Cognitive fatigue
- Irritability
- Thought acceleration
- Time distortion
- Increased libido
- Appetite suppression
- Light sensitivity
- Disinhibition
- Double vision
- Visual acuity suppression
- Acuity suppression
- Dulled perception
- Internal hallucination
- Internal hallucinations
Combinations
Cross-Check Amfecloral with another substanceHelpful Links
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