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    Apomorphine

    Aliases: Apokyn, Onapgo, Apo-go, Ixense, Uprima

    Stimulant

    Summary TheDrug.Wiki

    Apomorphine is primarily used to treat acute hypomobility episodes in advanced Parkinson's disease. Despite its name, it does not contain morphine and does not bind to opioid receptors. Nausea is extremely common; antiemetic pretreatment with trimethobenzamide or domperidone is typically required.

    Dose Information TheDrug.Wiki

    ROA Light Common Strong Heavy
    Sublingual 10mg - - -
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Comeup Peak Offset
    Subcutaneous 5-20 min 10-15 min 20-60 min 30-60 min
    Sublingual 10-30 min 15-30 min 30-90 min 30-60 min

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 4.2
    Moderate 4/10

    Strong anxiety/jitters with moderate stimulation, mild euphoria, low focus

    Stimulation / Energy ×3
    6
    stimulation wakefulness alertness enhancement
    Euphoria / Mood Lift ×2
    5
    euphoria motivation enhancement
    Focus / Productivity ×2
    2
    motivation enhancement
    ⚠ Anxiety / Jitters ×1
    8
    anxiety increased heart rate vasoconstriction
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Apomorphine
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Cross-Tolerances

    Other dopamine agonists (e.g., pramipexole, ropinirole)
    50%

    Effects TheDrug.Wiki

    Positive
    • Relief of Parkinsonian symptoms
    • Stimulation
    Negative
    • Nausea
    • Vomiting
    • Increased heart rate
    • Vasoconstriction
    • Insomnia
    Neutral
    • Yawning
    • Orthostatic hypotension
    • Sudden sleep onset
    Positive
    • Alertness enhancement
    • Euphoria
    • Wakefulness
    • Motivation enhancement
    Negative
    • Drowsiness
    • Dizziness
    • Anxiety
    Neutral
    • Compulsive behaviors
    • Talkativeness
    • Time distortion
    Positive
    • Increased music appreciation
    • Increased libido
    • Tactile enhancement
    • Color enhancement
    Negative
    • Light sensitivity
    • Appetite suppression
    • Dehydration
    • Disinhibition
    Neutral
    • Hallucinations
    • Drifting

    Combinations TripSit

    Pill Identifiers

    1 known pill identifiers on record — view imprints, colors, shapes, and images
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    Apomorphine's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    💊 Pill Identifier 📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki