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    Apomorphine Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 2 corroborating sources
    • 5 ROAs with full dose ladders
    • duration data present
    • 19 combo interactions documented
    • PubChem toxicity data

    Aliases: Apokyn, Onapgo, Apo-go, Ixense, Uprima

    Stimulant

    Summary TheDrug.Wiki

    Apomorphine is primarily used to treat acute hypomobility episodes in advanced Parkinson's disease. Despite its name, it does not contain morphine and does not bind to opioid receptors. Nausea is extremely common; antiemetic pretreatment with trimethobenzamide or domperidone is typically required.

    Dose Information TheDrug.Wiki PsychonautWiki

    ROA Light Common Strong Heavy
    Subcutaneous 1-2mg 2-4mg 4-8mg 8mg+
    Sublingual 10mg - - -
    Oral 2-5mg 5-10mg 10-15mg 15mg+
    Insufflated 0.5-1mg 1-2mg 2-4mg 4mg+
    Smoked 0.5-1mg 1-2mg 2-4mg 4mg+
    Intravenous 1-2mg 2-4mg 4-8mg 8mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Subcutaneous 5-15 min 1-2 hrs 1-2 hrs 30-60 min 1-12 hrs 1-2 hrs
    Sublingual 10-30 min 15-30 min 30-90 min 30-60 min - -
    Oral 15-30 min 20-40 min 1-2 hrs 30-60 min 1-12 hrs 2-4 hrs
    Insufflated 5-15 min 20-40 min 1-2 hrs 30-60 min 1-12 hrs 3-6 hrs
    Smoked 1-5 min 5-15 min 15-30 min 30-60 min 1-12 hrs 1-2 hrs
    Intravenous 1-5 min 5-15 min 15-30 min 30-60 min 1-12 hrs 1-2 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 4.2
    Moderate 4/10

    Strong anxiety/jitters with moderate stimulation, mild euphoria, low focus

    Stimulation / Energy ×3
    6
    stimulation wakefulness alertness enhancement
    Euphoria / Mood Lift ×2
    5
    euphoria motivation enhancement
    Focus / Productivity ×2
    2
    motivation enhancement
    ⚠ Anxiety / Jitters ×1
    8
    anxiety increased heart rate vasoconstriction
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Apomorphine
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Half tolerance 7d Baseline ~35d

    No robust human data on pharmacodynamic tolerance with intermittent rescue dosing; motor response may fluctuate with disease progression rather than classic tolerance. Impulse-control risks are class effects of dopamine agonists rather than tolerance phenomena.

    Cross-Tolerances

    Other dopamine agonists (e.g., pramipexole, ropinirole)
    50%

    Effects TheDrug.Wiki

    Positive
    • Relief of Parkinsonian symptoms
    • Stimulation
    Negative
    • Nausea
    • Vomiting
    • Increased heart rate
    • Vasoconstriction
    • Insomnia
    Neutral
    • Yawning
    • Orthostatic hypotension
    • Sudden sleep onset
    Positive
    • Alertness enhancement
    • Euphoria
    • Wakefulness
    • Motivation enhancement
    Negative
    • Drowsiness
    • Dizziness
    • Anxiety
    Neutral
    • Compulsive behaviors
    • Talkativeness
    • Time distortion
    Positive
    • Increased music appreciation
    • Increased libido
    • Tactile enhancement
    • Color enhancement
    Negative
    • Light sensitivity
    • Appetite suppression
    • Dehydration
    • Disinhibition
    Neutral
    • Hallucinations
    • Drifting

    Combinations TripSit

    Cross-Check Apomorphine with another substance

    Pill Identifiers

    1 known pill identifiers on record — view imprints, colors, shapes, and images
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    Apomorphine's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    💊 Pill Identifier 📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki