Atropine
Aliases: Atropin, Atropina, Atropinum, Dl-hyoscyamine, Dl-tropyltropate
Categories
Summary
Atropine is a naturally occurring tropane alkaloid found in Atropa belladonna and related nightshades. Medically it is employed to treat bradycardia, organophosphate poisoning, and to induce mydriasis. Recreational use is strongly discouraged: its psychoactive profile is characterised by true delirium, intense peripheral anticholinergic burden, and profound amnesia. The effective dose range for central effects lies dangerously close to the toxic and potentially lethal range; fatalities have occurred at doses only modestly above those that cause hallucinations. Individual sensitivity varies widely and children are especially vulnerable.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | - | - | - | 10+mg(oftentoxic)+ |
| Intravenous | 0.3-0.6mg | - | - | 2+mg(poisoningrisk)+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 30-60 min | 1-2 hrs | 1-3 hrs | 4-8 hrs | 24-72 hrs |
| Intravenous | 1-4 min | 5-15 min | 1-3 hrs | 4-8 hrs | 24-72 hrs |
Tolerance
Build-up
develops rapidly after a single use
Reset
7–14 days for baseline
Effects
Positive
Negative
- Extreme dry mouth and skin
- Dilated pupils and blurred vision
- Tachycardia and palpitations
- Flushing and hyperthermia
- Urinary retention and constipation
- Restlessness alternating with sedation
- Loss of balance
- Dry mouth
- Slurred or nonsensical speech
- Sedation
Positive
- Introspection
Negative
- Profound confusion and disorientation
- Retrograde and anterograde amnesia
- Paranoia or aggressive behaviour
- Dizziness
- Amnesia
- Anxiety
- Psychosis
- Confusion
- Delirium
Positive
- Color enhancement
- Auditory enhancement
Negative
- Photophobia
- Acuity suppression
- Visual distortions
- After images
- Auditory hallucinations
- Drifting
- External hallucinations
- Internal hallucinations