This is my report on atropine sulfate eye drops administered by a medical practitioner for pupil dilation for a eye exam. The practitioner administered 3 drops in each eye. The burning sensation immediately felt through my eyes.
Atropine
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- partial dose data
- duration data present
- toxicity data (PsychonautWiki)
- dose data not in PW/TripSit (unverifiable)
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- partial dose data
- duration data present
- toxicity data (PsychonautWiki)
- dose data not in PW/TripSit (unverifiable)
Aliases: Atropin, Atropina, Atropinum, Dl-hyoscyamine, Dl-tropyltropate
Summary
Atropine is a naturally occurring tropane alkaloid found in Atropa belladonna and related nightshades. Medically it is employed to treat bradycardia, organophosphate poisoning, and to induce mydriasis. Recreational use is strongly discouraged: its psychoactive profile is characterised by true delirium, intense peripheral anticholinergic burden, and profound amnesia.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | - | - | - | 10+mg (often toxic) |
| Intravenous | 0.3-0.6mg | - | - | 2+ mg (poisoning risk) |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 30-60 min | 1-2 hrs | 1-3 hrs | 4-8 hrs | 6.5-14 hrs |
| Intravenous | 1-4 min | 5-15 min | 1-3 hrs | 4-8 hrs | 5.1-11.32 hrs |
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Name
Atropine
Unit
mg
Description
Atropine Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 0.3 · heavy 10+ (often toxic) Intravenous dose (mg): threshold 0.2 (therapeutic) · light 0.3-0.6 · heavy 2+ (poisoning risk) Oral duration: onset 0.5-1h · come-up 1-2h · peak 1-3h · offset 4-8h · total 6.5-14h · after-effects 24-72h Intravenous duration: onset 1-4m · come-up 5-15m · peak 1-3h · offset 4-8h · total 5.1-11.32h · after-effects 24-72h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Build-up
develops rapidly after a single use
Reset
7–14 days for baseline
Tolerance Decay
Full tolerance
2d
Half tolerance
7d
Baseline
~14d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Limited and mostly anecdotal data: repeated daily exposure to antimuscarinics appears to blunt delirium intensity within 2–3 days but does not reliably protect from peripheral toxicity (tachycardia, anhidrosis, urinary retention). Cross‑tolerance across anticholinergic deliriants is plausible due to shared muscarinic antagonism, but quantitative relationships are unproven. Treat this section as precautionary and avoid any intentional ‘tolerance testing’.
Cross-Tolerances
Effects
Negative
- Extreme dry mouth and skin
- Dilated pupils and blurred vision
- Tachycardia and palpitations
- Flushing and hyperthermia
- Urinary retention and constipation
- Restlessness alternating with sedation
- Loss of balance
- Dry mouth
- Slurred or nonsensical speech
- Sedation
Positive
- Introspection
Negative
- Profound confusion and disorientation
- Retrograde and anterograde amnesia
- Paranoia or aggressive behaviour
- Dizziness
- Amnesia
- Anxiety
- Psychosis
- Confusion
- Delirium
Positive
- Color enhancement
- Auditory enhancement
Negative
- Photophobia
- Acuity suppression
- Visual distortions
- After images
- Auditory hallucinations
- Drifting
- External hallucinations
- Internal hallucinations
Combinations
Cross-Check Atropine with another substanceCommunity Trip Reports
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Erowid 1 report 1 cautionary visit
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