Atropine
Aliases: Atropin, Atropina, Atropinum, Dl-hyoscyamine, Dl-tropyltropate
Summary
Atropine is a naturally occurring tropane alkaloid found in Atropa belladonna and related nightshades. Medically it is employed to treat bradycardia, organophosphate poisoning, and to induce mydriasis. Recreational use is strongly discouraged: its psychoactive profile is characterised by true delirium, intense peripheral anticholinergic burden, and profound amnesia.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | - | - | - | 10+mg(oftentoxic)+ |
| Intravenous | 0.3-0.6mg | - | - | 2+mg(poisoningrisk)+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral | 30-60 min | 1-2 hrs | 1-3 hrs | 4-8 hrs |
| Intravenous | 1-4 min | 5-15 min | 1-3 hrs | 4-8 hrs |
Effect Profile
2 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong visuals and auditory effects with low headspace
Tolerance
Tolerance Decay
Limited and mostly anecdotal data: repeated daily exposure to antimuscarinics appears to blunt delirium intensity within 2–3 days but does not reliably protect from peripheral toxicity (tachycardia, anhidrosis, urinary retention). Cross‑tolerance across anticholinergic deliriants is plausible due to shared muscarinic antagonism, but quantitative relationships are unproven. Treat this section as precautionary and avoid any intentional ‘tolerance testing’.
Cross-Tolerances
Effects
- Extreme dry mouth and skin
- Dilated pupils and blurred vision
- Tachycardia and palpitations
- Flushing and hyperthermia
- Urinary retention and constipation
- Restlessness alternating with sedation
- Loss of balance
- Dry mouth
- Slurred or nonsensical speech
- Sedation
- Introspection
- Profound confusion and disorientation
- Retrograde and anterograde amnesia
- Paranoia or aggressive behaviour
- Dizziness
- Amnesia
- Anxiety
- Psychosis
- Confusion
- Delirium
- Color enhancement
- Auditory enhancement
- Photophobia
- Acuity suppression
- Visual distortions
- After images
- Auditory hallucinations
- Drifting
- External hallucinations
- Internal hallucinations