Avizafone
Aliases: Pro-diazepam
Summary
Avizafone (CAS 65617-86-9) is a water-soluble lysine prodrug of diazepam developed for rapid intramuscular administration in nerve-agent antidote kits. It cyclizes in plasma (t1/2 approximately 3-4 minutes) to diazepam with an elimination half-life of approximately 0.75 hours for the parent compound, while the resulting diazepam exhibits its typical 20-40 hour half-life. Community users exploit the powder's hygroscopic nature to prepare aqueous or PEG/ethanol solutions for oral dropper dosing but note variable potency (approximately 0.7-1.0x diazepam by mass) and sticky handling issues.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset |
|---|---|---|---|
| Oral (Solution / Capsule) | 15-45 min | 1-2 hrs | 3-6 hrs |
| Intramuscular | 5-15 min | 1-2 hrs | 3-6 hrs |
| Intranasal (Experimental) | 2-8 min | 1-2 hrs | 3-6 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Benzodiazepine
7.3
Strong+
7/10
Strong anxiolysis, euphoria, and cognitive impairment with mild sedation
Anxiolysis
×3
10
anxiety suppression
anxiolytic
muscle relaxation
muscle relaxant
emotion suppression
Sedation / Relaxation
×2
5
sedation
muscle relaxation
Motor / Cognitive Impairment
×1
9
motor control loss
amnesia
memory suppression
delusions of sobriety
Euphoria / Mood Lift
×1
10
cognitive euphoria
physical euphoria
disinhibition
Based on reports from:
Tolerance
Build-up
develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
Reset
weeks to months depending on half-life and duration of use; taper recommended
Cross-Tolerances
Effects
Positive
- Muscle relaxation
- Physical euphoria
- Anxiolytic
- Muscle Relaxant
Negative
- Motor impairment
- Respiratory depression
- Sedation
- Sedative
- Dystaxia
- Hypnotic
Positive
- Anxiety suppression
- Cognitive euphoria
Negative
- Amnesia
- Motor control loss
- Emotion suppression
- Thought deceleration
- Dizziness
- Delusions of sobriety
- Compulsive redosing
- Memory suppression
Positive
- Increased libido
- Increased music appreciation
- Appetite enhancement
Negative
- Disinhibition
- Acuity suppression
- Visual acuity suppression
- Dehydration
- Light sensitivity
- Dulled perception
- Perception of bodily heaviness
Combinations
Avizafone's nerd page
Pharmacology, chemical data, effect profiles, and more
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