Avizafone
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 3 ROAs with full dose ladders
- duration data present
- 17 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 1 source
- 3 ROAs with full dose ladders
- duration data present
- 17 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Pro-diazepam
Summary
Avizafone (CAS 65617-86-9) is a water-soluble lysine prodrug of diazepam developed for rapid intramuscular administration in nerve-agent antidote kits. It cyclizes in plasma (t1/2 approximately 3-4 minutes) to diazepam with an elimination half-life of approximately 0.75 hours for the parent compound, while the resulting diazepam exhibits its typical 20-40 hour half-life. Community users exploit the powder's hygroscopic nature to prepare aqueous or PEG/ethanol solutions for oral dropper dosing but note variable potency (approximately 0.7-1.0x diazepam by mass) and sticky handling issues.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-15mg | 15-30mg | 30-60mg | 60mg+ |
| Intramuscular | 5-10mg | 10-20mg | 20-30mg | 30mg+ |
| Insufflated | 5-10mg | 10-15mg | 15-20mg | 20mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 15-60 min | 1-2 hrs | 3-8 hrs | 6-24 hrs |
| Intramuscular | 10-30 min | 1-2 hrs | 3-8 hrs | 6-24 hrs |
| Insufflated | - | 1-2 hrs | 3-8 hrs | 6-24 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong anxiolysis, euphoria, and cognitive impairment with mild sedation
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Tolerance builds with repeated near‑daily exposure; cross‑tolerance extends to other benzodiazepines. Data are inferred from diazepam and benzodiazepine class behavior; exact rates are not quantified in open sources.
Cross-Tolerances
Effects
- Muscle relaxation
- Physical euphoria
- Anxiolytic
- Muscle Relaxant
- Motor impairment
- Respiratory depression
- Sedation
- Sedative
- Dystaxia
- Hypnotic
- Anxiety suppression
- Cognitive euphoria
- Amnesia
- Motor control loss
- Emotion suppression
- Thought deceleration
- Dizziness
- Delusions of sobriety
- Compulsive redosing
- Memory suppression
- Increased libido
- Increased music appreciation
- Appetite enhancement
- Disinhibition
- Acuity suppression
- Visual acuity suppression
- Dehydration
- Light sensitivity
- Dulled perception
- Perception of bodily heaviness
Combinations
Cross-Check Avizafone with another substanceHelpful Links
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Avizafone? Let us know. Reports are reviewed by moderators — this is not posted publicly.