Summary
Avizafone (CAS 65617-86-9) is a water-soluble lysine prodrug of diazepam developed for rapid intramuscular administration in nerve-agent antidote kits. It cyclizes in plasma (t1/2 approximately 3-4 minutes) to diazepam with an elimination half-life of approximately 0.75 hours for the parent compound, while the resulting diazepam exhibits its typical 20-40 hour half-life. Community users exploit the powder's hygroscopic nature to prepare aqueous or PEG/ethanol solutions for oral dropper dosing but note variable potency (approximately 0.7-1.0x diazepam by mass) and sticky handling issues. Subjective reports describe a flat diazepam-like sedation with strong muscle relaxation yet reduced euphoria unless 50-75 mg or higher doses are taken. High doses may reveal nonlinear conversion kinetics.
Dose Information
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Oral (Solution / Capsule) | 15-45 min | 1-2 hrs | 3-6 hrs | 24 hrs |
| Intramuscular | 5-15 min | 1-2 hrs | 3-6 hrs | 24 hrs |
| Intranasal (Experimental) | 2-8 min | 1-2 hrs | 3-6 hrs | 24 hrs |
Tolerance
Effects
- Muscle relaxation
- Physical euphoria
- Anxiolytic
- Muscle Relaxant
- Motor impairment
- Respiratory depression
- Sedation
- Sedative
- Dystaxia
- Hypnotic
- Anxiety suppression
- Cognitive euphoria
- Amnesia
- Motor control loss
- Emotion suppression
- Thought deceleration
- Dizziness
- Delusions of sobriety
- Compulsive redosing
- Memory suppression
- Increased libido
- Increased music appreciation
- Appetite enhancement
- Disinhibition
- Acuity suppression
- Visual acuity suppression
- Dehydration
- Light sensitivity
- Dulled perception
- Perception of bodily heaviness