Avizafone
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 17 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- 17 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Pro-diazepam
Summary
Avizafone (CAS 65617-86-9) is a water-soluble lysine prodrug of diazepam developed for rapid intramuscular administration in nerve-agent antidote kits. It cyclizes in plasma (t1/2 approximately 3-4 minutes) to diazepam with an elimination half-life of approximately 0.75 hours for the parent compound, while the resulting diazepam exhibits its typical 20-40 hour half-life. Community users exploit the powder's hygroscopic nature to prepare aqueous or PEG/ethanol solutions for oral dropper dosing but note variable potency (approximately 0.7-1.0x diazepam by mass) and sticky handling issues.
Dose Information
Dose basis. Ranges are aggregated from community reports; no peer‑reviewed human dosing monograph exists. Oral avizafone is a prodrug to diazepam. Due to molecular weight differences and variable conversion, mg-for-mg potency is expected to be lower than diazepam. Start low and titrate cautiously; see notes and interactions for factors that increase potency (e.g., CYP2C19/CYP3A4 inhibition). Anecdotal reports indicate substantial between‑person variability. Intended clinical route in legacy research. Use of non‑sterile solvents or technique risks abscess, cellulitis, and systemic infection. Water‑soluble avizafone does not require propylene glycol; avoid improvised PG/EtOH injectates. If someone chooses to IM despite risks, use new sterile equipment, bacteriostatic/sterile water, rotate sites, and never share supplies. Community reports only; not a recommendation. (Dose figures and this note are from Drugs.Wiki.)
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-15mg | 15-30mg | 30-60mg | 60mg+ |
| Intramuscular | 5-10mg | 10-20mg | 20-30mg | 30mg+ |
| Insufflated | 5-10mg | 10-15mg | 15-20mg | 20mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 15-60 min | - | 3-8 hrs | 6-24 hrs |
| Intramuscular | 5-15 min | 1-2 hrs | 3-6 hrs | 4.08-8.25 hrs |
| Insufflated | 1-10 min | - | 3-8 hrs | 6-24 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong anxiolysis, euphoria, and cognitive impairment with mild sedation
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Avizafone there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Avizafone Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 2-5 · light 5-15 · common 15-30 · strong 30-60 · heavy 60+ Intramuscular dose (mg): threshold 2.5 · light 5-10 · common 10-20 · strong 20-30 · heavy 30+ Insufflated dose (mg): threshold 2-5 · light 5-10 · common 10-15 · strong 15-20 · heavy 20+ Oral duration: onset 0.25-1h · offset 3-8h · total 6-24h · after-effects 12-48h Intramuscular duration: onset 5-15m · peak 1-2h · offset 3-6h · total 4.08-8.25h · after-effects 24h Insufflated duration: onset 1-10m · offset 3-8h · total 6-24h · after-effects 12-48h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 22.5 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Tolerance builds with repeated near‑daily exposure; cross‑tolerance extends to other benzodiazepines. Data are inferred from diazepam and benzodiazepine class behavior; exact rates are not quantified in open sources.
Cross-Tolerances
Effects
- Muscle relaxation
- Physical euphoria
- Anxiolytic
- Muscle Relaxant
- Motor impairment
- Respiratory depression
- Sedation
- Sedative
- Dystaxia
- Hypnotic
- Anxiety suppression
- Cognitive euphoria
- Amnesia
- Motor control loss
- Emotion suppression
- Thought deceleration
- Dizziness
- Delusions of sobriety
- Compulsive redosing
- Memory suppression
- Increased libido
- Increased music appreciation
- Appetite enhancement
- Disinhibition
- Acuity suppression
- Visual acuity suppression
- Dehydration
- Light sensitivity
- Dulled perception
- Perception of bodily heaviness
Combinations
Cross-Check Avizafone with another substanceHelpful Links
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