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    Bromazolam molecular structure

    Bromazolam Stats & Data

    Brom Bromaz Xli-268 xli268
    NPS DataHub
    MW353.22
    FormulaC17H13BrN4
    CAS71368-80-4
    IUPAC8-bromo-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
    SMILESBrc1ccc2c(c1)C(=NCc1nnc(C)n12)c1ccccc1
    InChIKeyKCEIOBKDDQAYCM-UHFFFAOYSA-N
    Benzodiazepines; 2020/3. Benzodiazepine; 2021/3. Benzodiazepine; 2022/3. Benzodiazepine
    Chemical Class Benzodiazepine
    Psychoactive Class Depressant

    Receptor Profile

    Receptor Actions

    Agonists
    non-subtype selective GABAA receptor agonist with binding affinity of 2.81 nM at α1, 0.69 nM at α2, and 0.62 nM at α5 subunits
    Modulators
    Gamma-aminobutyric acid type A receptor positive allosteric modulator (benzodiazepine site)

    History & Culture

    Bromazolam was first synthesized in 1976 as part of benzodiazepine research, representing a structural modification of alprazolam where the chlorine atom is replaced with bromine. Despite its early synthesis, the compound was never developed as a pharmaceutical product or brought to market for medical use. The substance remained largely obscure until it emerged in the designer drug market decades later. In 2016, bromazolam was definitively identified by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) after appearing in Sweden, marking its entry into the novel psychoactive substances landscape. Since then, it has become one of the more prevalent novel benzodiazepines in circulation. In parts of North America, particularly Canada, bromazolam has become intertwined with the illicit opioid supply. Street-level products combining bromazolam with opioids such as heroin or fentanyl analogues have emerged, sometimes referred to colloquially as "benzo-dope." This adulteration pattern has raised significant public health concerns due to the compounded risks of combining central nervous system depressants.

    Effect Profile

    Curated + 4 Reports
    Benzodiazepine 7.1

    Strong anxiolysis, cognitive impairment, and euphoria with mild sedation

    Anxiolysis×3
    10
    Sedation / Relaxation×2
    5
    Motor / Cognitive Impairment×1
    10
    Euphoria / Mood Lift×1
    10

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 3d Half tolerance 37d Baseline ~60d

    Cross-Tolerances

    Alprazolam
    85% ●○○
    Diazepam
    85% ●○○
    Clonazepam
    85% ●○○
    Lorazepam
    85% ●○○
    Etizolam
    85% ●○○
    Clonazolam
    85% ●○○
    Flualprazolam
    85% ●○○
    Flubromazolam
    85% ●○○

    Experience Report Analysis

    Erowid
    4 Reports
    2022–2024 Date Range
    4 With Age Data
    2 Effects Detected

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Effect Analysis

    Erowid

    Effects aggregated from 4 experience reports (4 Erowid)

    4 Reports
    2 Effects Detected
    1 Positive
    1 Adverse
    0 Neutral

    Effect Sentiment Distribution

    Confidence Distribution

    Positive Effects 1

    Sedation 75.0% 70%

    Adverse Effects 1

    Confusion 75.0% 70%

    Form / Preparation

    Most common forms and preparations reported

    Legal Status

    Country Status Notes
    United Kingdom Class C Classified as a Class C controlled substance under UK drug control legislation. Class C represents the lowest tier of controlled substances, with possession, supply, and production without authorization constituting criminal offenses.
    United States Unscheduled (federal); Schedule I pending January 2026 Currently unscheduled at the federal level. Pursuant to a Drug Enforcement Administration notice, bromazolam will be placed into Schedule I on January 14, 2026 for two years with a possible one-year extension. Several states, including Virginia, have independently classified bromazolam as Schedule I at the state level, though notably excluding the related analog phenazolam. Despite its current federal unscheduled status, arrests have occurred for mismarketing bromazolam as alprazolam in counterfeit Xanax-shaped tablets, resulting in counterfeit drug charges. The U.S. Department of Justice reported in June 2022 that bromazolam seizures were surging nationwide, frequently detected alongside fentanyl in the illicit drug supply.
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