Summary
CBC is a rare, non-intoxicating cannabinoid found in small amounts in Cannabis sativa. It shows preferential affinity for CB2 receptors, TRPA1, TRPV1, and other TRP channels, demonstrating anti-inflammatory, analgesic, anticonvulsant, antidepressant-like, and neuroprotective properties in preclinical studies. Human data are sparse; most information derives from animal studies and anecdotal reports with commercial CBC isolates.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral | 30-90 min | 30-60 min | 1-3 hrs | 2-4 hrs |
Tolerance
Build-up
develops over weeks of regular use via CB1 receptor downregulation
Reset
2–4 weeks for most users; heavy users may need longer
Tolerance Decay
Full tolerance
14d
Half tolerance
14d
Baseline
~28d
No controlled human data. Tolerance, if any, appears to build slowly with daily use and decays over weeks, extrapolated from general cannabinoid exposure patterns and user reports.
Cross-Tolerances
Effects
Positive
- Anxiolysis
- Body relaxation
- Pain relief
- Anti-inflammatory relief
- Stimulation
Negative
- Increased heart rate
- Nausea
- Headaches
- Headache
- Sedation
Positive
- Clear-headed focus
- Mild mood lift
- Reduced anxiety
- Wakefulness
- Motivation enhancement
- Focus enhancement
- Memory enhancement
- Anxiety suppression
- Cognitive euphoria
Negative
- Anxiety
Positive
- Increased libido
- Increased music appreciation
- Increased Music Appreciation
- Color enhancement
Negative
- Light sensitivity
- Appetite suppression
- Dehydration
- Appetite Suppression
- Dulled perception
- Spontaneous physical sensations
Combinations
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Pharmacology, chemical data, effect profiles, and more
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