Summary
CBC is a rare, non-intoxicating cannabinoid found in small amounts in Cannabis sativa. It shows preferential affinity for CB2 receptors, TRPA1, TRPV1, and other TRP channels, demonstrating anti-inflammatory, analgesic, anticonvulsant, antidepressant-like, and neuroprotective properties in preclinical studies. Human data are sparse; most information derives from animal studies and anecdotal reports with commercial CBC isolates. CBC is metabolized primarily by CYP2C9 and shows minimal to weak inhibitory effects on CYP450 enzymes. Monitor medications metabolized by CYP2C9 and 2C19, particularly those with narrow therapeutic indices.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 30-90 min | 30-60 min | 1-3 hrs | 2-4 hrs | 2-12 hrs |
| Vaporized | 0-5 min | 5-15 min | 10-30 min | 30-60 min | 2-12 hrs |
Tolerance
Build-up
develops over weeks of regular use via CB1 receptor downregulation
Reset
2–4 weeks for most users; heavy users may need longer
Effects
Positive
- Anxiolysis
- Body relaxation
- Pain relief
- Anti-inflammatory relief
- Stimulation
Negative
- Increased heart rate
- Nausea
- Headaches
- Headache
- Sedation
Positive
- Clear-headed focus
- Mild mood lift
- Reduced anxiety
- Wakefulness
- Motivation enhancement
- Focus enhancement
- Memory enhancement
- Anxiety suppression
- Cognitive euphoria
Negative
- Anxiety
Positive
- Increased libido
- Increased music appreciation
- Increased Music Appreciation
- Color enhancement
Negative
- Light sensitivity
- Appetite suppression
- Dehydration
- Appetite Suppression
- Dulled perception
- Spontaneous physical sensations