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    CBC Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 16 combo interactions documented
    • toxicity data (PsychonautWiki)
    • dose data not in PW/TripSit (unverifiable)

    Depressant Nootropic Cannabinoid

    Summary dose.wiki

    CBC is a rare, non-intoxicating cannabinoid found in small amounts in Cannabis sativa. It shows preferential affinity for CB2 receptors, TRPA1, TRPV1, and other TRP channels, demonstrating anti-inflammatory, analgesic, anticonvulsant, antidepressant-like, and neuroprotective properties in preclinical studies. Human data are sparse; most information derives from animal studies and anecdotal reports with commercial CBC isolates.

    Dose Information dose.wiki Drugs.Wiki

    Dose basis. Ranges compiled from commercial CBC isolate labels and user reports; no controlled human titration studies exist. Interindividual variability likely high; treat as provisional and titrate cautiously. Ranges inferred from user reports and typical fill strengths; delivered mg per puff varies with device temperature and puff duration. Start at the low end to assess airway sensitivity due to TRPA1 agonism of CBC. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 10-30mg 30-70mg 70-150mg 150mg+
    Vaporized 1-5mg 5-20mg 20-50mg 50mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 30-90 min 30-60 min 1-3 hrs 2-4 hrs 2-12 hrs 4-9.5 hrs
    Vaporized 0-5 min 5-15 min 10-30 min 30-60 min 2-12 hrs 0.75-1.83 hrs

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track CBC there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "CBC (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    CBC
    Unit
    mg
    Description 
    CBC
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 5 · light 10-30 · common 30-70 · strong 70-150 · heavy 150+
Vaporized dose (mg): threshold 1 · light 1-5 · common 5-20 · strong 20-50 · heavy 50+

Oral duration: onset 0.5-1.5h · come-up 0.5-1h · peak 1-3h · offset 2-4h · total 4-9.5h · after-effects 2-12h
Vaporized duration: onset 0-5m · come-up 5-15m · peak 10-30m · offset 0.5-1h · total 0.75-1.83h · after-effects 2-12h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 50 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over weeks of regular use via CB1 receptor downregulation
    Reset 2–4 weeks for most users; heavy users may need longer

    Tolerance Decay

    Full tolerance 14d Half tolerance 14d Baseline ~28d

    No controlled human data. Tolerance, if any, appears to build slowly with daily use and decays over weeks, extrapolated from general cannabinoid exposure patterns and user reports.

    Cross-Tolerances

    Other cannabinoids (partial)
    30%

    Effects dose.wiki

    Positive
    • Anxiolysis
    • Body relaxation
    • Pain relief
    • Anti-inflammatory relief
    • Stimulation
    Negative
    • Increased heart rate
    • Nausea
    • Headaches
    • Headache
    Neutral
    • Sedation
    Positive
    • Clear-headed focus
    • Mild mood lift
    • Reduced anxiety
    • Wakefulness
    • Motivation enhancement
    • Focus enhancement
    • Memory enhancement
    • Anxiety suppression
    • Cognitive euphoria
    Negative
    • Anxiety
    Positive
    • Increased libido
    • Increased music appreciation
    • Color enhancement
    Negative
    • Light sensitivity
    • Appetite suppression
    • Dehydration
    Neutral
    • Dulled perception
    • Spontaneous physical sensations

    Combinations

    Cross-Check CBC with another substance

    CBC's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    💊 Pill Identifier 📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki