CBL
Aliases: Cbp, Cannabipinol, Pentylcannabicyclol
Summary
CBL is a photodegradation product of cannabichromene (CBC), occurring naturally in aged or UV-exposed Cannabis. Human pharmacology remains almost completely unstudied; however, recent 2025 research revealed CBL has high affinity for the 5-HT1A serotonin receptor, acting as a potent positive allosteric modulator at low concentrations. A 1976 study in rabbits showed convulsions and death at 8 mg/kg, though this limited two-animal study offers minimal guidance for human safety.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | Nodata | - | - | - |
| Sublingual | Nodata | - | - | - |
| Inhaled | Nodata | - | - | - |
Light
Common
Strong
Heavy
Tolerance
Build-up
develops over weeks of regular use via CB1 receptor downregulation
Reset
2–4 weeks for most users; heavy users may need longer
Effects
Combinations
CBL's nerd page
Pharmacology, chemical data, effect profiles, and more
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