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    Clobromazolam molecular structure

    Clobromazolam Stats & Data

    Dm-ii-90 Phenazolam Brn 4550445
    NPS DataHub
    MW387.67
    FormulaC17H12BrClN4
    CAS87213-50-1
    IUPAC8-bromo-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
    SMILESBrc1ccc2c(c1)C(=NCc1nnc(C)n12)c1ccccc1Cl
    InChIKeyBUTCFAZTKZDYCN-UHFFFAOYSA-N
    Benzodiazepines
    Chemical Class Triazolobenzodiazepine
    Psychoactive Class Depressant

    Effect Profile

    Curated
    Benzodiazepine 7.7

    Strong anxiolysis and sedation with strong cognitive impairment, moderate euphoria

    Anxiolysis×3
    10
    Sedation / Relaxation×2
    8
    Motor / Cognitive Impairment×1
    8
    Euphoria / Mood Lift×1
    6

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Unknown in humans; practical sedation often persists 12–24+ h per reports
    Addiction Potential
    High: very potent with strong amnesia and delusions of sobriety; rapid tolerance and dependence with daily or frequent use; severe benzodiazepine withdrawal risk.

    No tolerance chart. Our decay curves for these drugs were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.

    How fast tolerance to these drugs fades after a break has not been measured well enough to draw, so don't count on a dose you used to take still being safe: after time off, start with a much smaller amount and don't use alone. Mixing sedatives with each other, with alcohol or with opioids sharply raises the risk of a fatal overdose. If you've been using regularly, don't stop suddenly: withdrawal from benzodiazepines, alcohol or GHB/GBL can cause seizures or delirium, so get medical help to cut down gradually.

    Sources: FRANK: benzodiazepines · Alcohol and Drug Foundation: GHB · FDA 2020: benzodiazepine boxed warning · FDA 2019: gabapentinoids and breathing · NHS: alcohol use disorder

    Cross-Tolerances

    all benzodiazepines
    Z‑drugs (zolpidem, zopiclone)
    thieno-/triazolo‑benzodiazepines

    Harm Reduction

    drugs.wiki

    Phenazolam is the same compound as clobromazolam; it first appeared on the market circa 2016 and has no approved medical use. Forum meta-reports consistently place its potency in the sub‑milligram range, with ~0.25 mg often compared to a typical anxiolytic dose range of diazepam; avoid any pressed tablets claiming multi‑milligram doses. Onset is notably slow for a triazolobenzodiazepine (often 1–2 h, sometimes 3 h), which greatly increases redosing risk and blackout potential. Volumetric dosing is essential: dissolve a known amount in a measured volume (e.g., 1 mg in 10–20 mL ethanol/propylene glycol), mix thoroughly, and measure doses with an oral syringe; do not eyeball powders or shave tablets. Wait a full 3–4 hours before considering any redose due to delayed peak and amnesia. Multiple reports describe next‑day impairment lasting well beyond the perceived high; avoid driving or hazardous tasks for at least 24 h after dosing. Novel benzodiazepines are widely found in counterfeit ‘Xanax/Valium’-type tablets and in non‑benzo samples; mislabeling and extreme dose variability have been repeatedly documented by drug‑checking and early warning systems — treat unknown tablets/solutions as suspect and test where possible. Combining with opioids, alcohol, GHB/GBL, dissociatives, or gabapentinoids is the main cause of life‑threatening events; treat these as hard contraindications. Naloxone reverses opioids but not benzodiazepines; always prioritize airway and breathing in mixed‑drug poisonings until help arrives. Flumazenil can precipitate acute withdrawal and seizures in dependent users and should only be given in a clinical setting by trained staff. Because supply may include bromazolam or other benzos mis‑sold as clobromazolam, assume mislabeling until proven otherwise and start at the absolute minimum dose.

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