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    Clobromazolam molecular structure

    Clobromazolam Stats & Data

    Dm-ii-90 Phenazolam Brn 4550445
    NPS DataHub
    MW387.67
    FormulaC17H12BrClN4
    CAS87213-50-1
    IUPAC8-bromo-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
    SMILESBrc1ccc2c(c1)C(=NCc1nnc(C)n12)c1ccccc1Cl
    InChIKeyBUTCFAZTKZDYCN-UHFFFAOYSA-N
    Benzodiazepines; 2020/3. Benzodiazepine; 2021/3. Benzodiazepine; 2022/3. Benzodiazepine
    Chemical Class Benzodiazepine
    Psychoactive Class Depressant
    Half-Life Unknown in humans; practical sedation often persists 12–24+ h per reports

    Effect Profile

    Curated
    Benzodiazepine 7.7

    Strong anxiolysis, sedation, and cognitive impairment with moderate euphoria

    Anxiolysis×3
    10
    Sedation / Relaxation×2
    8
    Motor / Cognitive Impairment×1
    8
    Euphoria / Mood Lift×1
    6

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Unknown in humans; practical sedation often persists 12–24+ h per reports
    Addiction Potential
    High: very potent with strong amnesia and delusions of sobriety; rapid tolerance and dependence with daily or frequent use; severe benzodiazepine withdrawal risk.

    Tolerance Decay

    Full tolerance 3d Half tolerance 14d Baseline ~28d

    Benzodiazepine sedative/hypnotic tolerance can develop rapidly with daily use; partial reversal requires weeks to months of abstinence and is highly individualized. Data are largely anecdotal; treat any numerical model as a rough guide only. Avoid consecutive‑day use to limit tolerance and dependence risk.

    Cross-Tolerances

    all benzodiazepines
    80% ●○○
    Z‑drugs (zolpidem, zopiclone)
    50% ●○○
    thieno-/triazolo‑benzodiazepines
    80% ●○○

    Harm Reduction

    drugs.wiki

    Phenazolam is the same compound as clobromazolam; it first appeared on the market circa 2016 and has no approved medical use. Forum meta-reports consistently place its potency in the sub‑milligram range, with ~0.25 mg often compared to a typical anxiolytic dose range of diazepam; avoid any pressed tablets claiming multi‑milligram doses. Onset is notably slow for a triazolobenzodiazepine (often 1–2 h, sometimes 3 h), which greatly increases redosing risk and blackout potential. Volumetric dosing is essential: dissolve a known amount in a measured volume (e.g., 1 mg in 10–20 mL ethanol/propylene glycol), mix thoroughly, and measure doses with an oral syringe; do not eyeball powders or shave tablets. Wait a full 3–4 hours before considering any redose due to delayed peak and amnesia. Multiple reports describe next‑day impairment lasting well beyond the perceived high; avoid driving or hazardous tasks for at least 24 h after dosing. Novel benzodiazepines are widely found in counterfeit ‘Xanax/Valium’-type tablets and in non‑benzo samples; mislabeling and extreme dose variability have been repeatedly documented by drug‑checking and early warning systems — treat unknown tablets/solutions as suspect and test where possible. Combining with opioids, alcohol, GHB/GBL, dissociatives, or gabapentinoids is the main cause of life‑threatening events; treat these as hard contraindications. Naloxone reverses opioids but not benzodiazepines; always prioritize airway and breathing in mixed‑drug poisonings until help arrives. Flumazenil can precipitate acute withdrawal and seizures in dependent users and should only be given in a clinical setting by trained staff. Because supply may include bromazolam or other benzos mis‑sold as clobromazolam, assume mislabeling until proven otherwise and start at the absolute minimum dose.

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