Home
    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    Clomethiazole

    Depressant Research-chemical Opioid

    Summary TripSit

    Structurally related to Thiamine (vitamin B1), but with binding potential at the GABAa site, which causes it to produce effects most like those of a barbiturate: an effective sedative and hypnotic. Originally developed by Hoffman-LaRoche in the 1930s, it has seen use as a treatment for acute alcohol withdrawal.

    Dose Information TripSit

    ROA Light Common Strong Heavy
    Oral 100-150mg 150-200mg - 200mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TripSit

    ROA Onset Peak After Effects Total
    Oral 15-40 min 5-8 hrs 1-16 hrs 5.2-8.7 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 4.7
    Moderate+ 5/10

    Moderate euphoria with mild sedation

    Euphoria / Warmth ×3
    6
    euphoria cognitive euphoria
    Analgesia ×2
    0
    Sedation / Relaxation ×1
    5
    sedation muscle relaxant
    ⚠ Itching / Nausea ×1
    0
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Clomethiazole
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 1d Half tolerance 21d Baseline ~35d

    Effects TripSit

    Positive
    • Anxiolytic
    • Muscle Relaxant
    • Stimulation
    Negative
    • Increased heart rate
    • Pupil dilation
    • Insomnia
    Neutral
    • Sedative
    • Dystaxia
    • Hypnotic
    • Sedation
    Positive
    • Reduced anxiety
    • Euphoria
    • Cognitive euphoria
    • Wakefulness
    • Empathy
    Negative
    • Amnesia
    • Anxiety
    • Confusion
    • Compulsive redosing
    Neutral
    • Time distortion
    Positive
    • Increased music appreciation
    • Color enhancement
    • Brightened colour
    • Tactile enhancement
    Negative
    • Light sensitivity
    • Disinhibition
    • Appetite suppression
    • Dehydration
    Neutral
    • Dulled perception
    • Drifting

    Combinations TripSit

    Clomethiazole's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 TripSit 📖 PsychonautWiki