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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    Clomethiazole Limited data
    Limited data
    Sparse data. Doses and effects may be unreliable or untested.
    • 1 source
    • partial dose data
    • duration data present
    • 19 combo interactions documented
    • classified Tentative
    • classified Research-chemical

    Depressant Research-chemical Opioid

    Summary TripSit

    Structurally related to Thiamine (vitamin B1), but with binding potential at the GABAa site, which causes it to produce effects most like those of a barbiturate: an effective sedative and hypnotic. Originally developed by Hoffman-LaRoche in the 1930s, it has seen use as a treatment for acute alcohol withdrawal.

    Dose Information TripSit

    ROA Light Common Strong Heavy
    Oral 100-150mg 150-200mg - 200mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TripSit

    ROA Onset Peak After Effects Total
    Oral 15-40 min 5-8 hrs 1-16 hrs 5-8 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 4.7
    Moderate+ 5/10

    Moderate euphoria with mild sedation

    Euphoria / Warmth ×3
    6
    euphoria cognitive euphoria
    Analgesia ×2
    0
    Sedation / Relaxation ×1
    5
    sedation muscle relaxant
    ⚠ Itching / Nausea ×1
    0
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Clomethiazole
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 1d Half tolerance 21d Baseline ~35d

    Effects TripSit

    Positive
    • Anxiolytic
    • Muscle Relaxant
    • Stimulation
    Negative
    • Increased heart rate
    • Pupil dilation
    • Insomnia
    Neutral
    • Sedative
    • Dystaxia
    • Hypnotic
    • Sedation
    Positive
    • Reduced anxiety
    • Euphoria
    • Cognitive euphoria
    • Wakefulness
    • Empathy
    Negative
    • Amnesia
    • Anxiety
    • Confusion
    • Compulsive redosing
    Neutral
    • Time distortion
    Positive
    • Increased music appreciation
    • Color enhancement
    • Brightened colour
    • Tactile enhancement
    Negative
    • Light sensitivity
    • Disinhibition
    • Appetite suppression
    • Dehydration
    Neutral
    • Dulled perception
    • Drifting

    Combinations TripSit

    Cross-Check Clomethiazole with another substance

    Clomethiazole's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TripSit 📖 PsychonautWiki