Summary
Structurally related to Thiamine (vitamin B1), but with binding potential at the GABAa site, which causes it to produce effects most like those of a barbiturate: an effective sedative and hypnotic. Originally developed by Hoffman-LaRoche in the 1930s, it has seen use as a treatment for acute alcohol withdrawal.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 100-150mg | 150-200mg | - | 200mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | After Effects | Total |
|---|---|---|---|---|
| Oral | 15-40 min | 5.0-8.0 hrs | 1.0-16.0 hrs | 300-0 min |
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Effects
Positive
- Anxiolytic
- Muscle Relaxant
- Stimulation
Negative
- Increased heart rate
- Pupil dilation
- Insomnia
- Sedative
- Dystaxia
- Hypnotic
- Sedation
Positive
- Reduced anxiety
- Euphoria
- Cognitive euphoria
- Wakefulness
- Empathy
Negative
- Amnesia
- Anxiety
- Confusion
- Compulsive redosing
- Time distortion
Positive
- Increased music appreciation
- Color enhancement
- Brightened colour
- Tactile enhancement
Negative
- Light sensitivity
- Disinhibition
- Appetite suppression
- Dehydration
- Dulled perception
- Drifting