Summary
Cocaethylene is not found in nature and forms exclusively in the liver through transesterification when cocaine and alcohol are consumed together. It carries 18-25 times greater risk of immediate death compared to cocaine alone. Cocaethylene is more cardiotoxic and hepatotoxic than either parent substance, with increased risk of seizures, liver damage, compromised immune function, and sudden cardiac death. The metabolite has a longer half-life than cocaine, prolonging euphoric effects while significantly increasing health risks. There is no safe dose, and concurrent use of cocaine and alcohol should be avoided.
Dose Information
Light
Common
Strong
Heavy
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute tolerance; longer for full reset
Effects
Positive
- Increased energy
- Stimulation
- Physical euphoria
- Pain relief
Negative
- Cardiovascular stimulation
- Increased heart rate
- Nausea
- Pupil dilation
- Abnormal heartbeat
- Sedation
Positive
- Enhanced euphoria
- Increased confidence
- Increased sociability
- Cognitive euphoria
Negative
- Anxiety
- Paranoia
- Dizziness
- Reduced inhibition
- Time distortion
- Increased risk-taking behavior
Positive
- Increased libido
- Auditory enhancement
Negative
- Light sensitivity
- Appetite suppression
- Drifting
- Internal hallucination
- Auditory hallucinations
- Internal hallucinations
- Perception of increased weight
- Auditory distortion