Cocaethylene
Aliases: Homocaine, Ethylcocaine
Summary
Cocaethylene is not found in nature and forms exclusively in the liver through transesterification when cocaine and alcohol are consumed together. It carries 18-25 times greater risk of immediate death compared to cocaine alone. Cocaethylene is more cardiotoxic and hepatotoxic than either parent substance, with increased risk of seizures, liver damage, compromised immune function, and sudden cardiac death.
Dose Information
Light
Common
Strong
Heavy
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Stimulant
4.6
Moderate+
5/10
Strong euphoria and anxiety/jitters with mild stimulation
Stimulation / Energy
×3
5
increased energy
stimulation
Euphoria / Mood Lift
×2
10
physical euphoria
cognitive euphoria
enhanced euphoria
increased confidence
Focus / Productivity
×2
0
Anxiety / Jitters
×1
8
anxiety
paranoia
increased heart rate
Based on reports from:
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute tolerance; longer for full reset
Tolerance Decay
Full tolerance
1d
Half tolerance
10d
Baseline
~18d
Effects
Positive
- Increased energy
- Stimulation
- Physical euphoria
- Pain relief
Negative
- Cardiovascular stimulation
- Increased heart rate
- Nausea
- Pupil dilation
- Abnormal heartbeat
- Sedation
Positive
- Enhanced euphoria
- Increased confidence
- Increased sociability
- Cognitive euphoria
Negative
- Anxiety
- Paranoia
- Dizziness
- Reduced inhibition
- Time distortion
- Increased risk-taking behavior
Positive
- Increased libido
- Auditory enhancement
Negative
- Light sensitivity
- Appetite suppression
- Drifting
- Internal hallucination
- Auditory hallucinations
- Internal hallucinations
- Perception of increased weight
- Auditory distortion
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