My drug background: I'm normally a stim-loving girl - meth and adderall - and I sometimes do coke, although overall I'm underwhelmed by it. I mean, it's nice, but just nice, not awesome. And It doesn't fuck me up seriously, just buzzes me a bit.
Cocaethylene
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
Aliases: Homocaine, Ethylcocaine
Summary
Cocaethylene is not found in nature and forms exclusively in the liver through transesterification when cocaine and alcohol are consumed together. It carries 18-25 times greater risk of immediate death compared to cocaine alone. Cocaethylene is more cardiotoxic and hepatotoxic than either parent substance, with increased risk of seizures, liver damage, compromised immune function, and sudden cardiac death.
Dose Information
| ROA | Threshold |
|---|---|
| Endogenous Formation | Not applicable - cocaethylene is formed endogenously in the liver when cocaine and alcohol are consumed together |
Only a threshold dose is documented for this substance — the smallest amount with a noticeable effect. There is no published light/common/strong ladder to show above it.
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Stimulant
4.6
Moderate+
5/10
Strong euphoria and anxiety/jitters with mild stimulation
Stimulation / Energy
×3
5
increased energy
stimulation
Euphoria / Mood Lift
×2
10
physical euphoria
cognitive euphoria
enhanced euphoria
increased confidence
Focus / Productivity
×2
0
Anxiety / Jitters
×1
8
anxiety
paranoia
increased heart rate
Add to PsychonautWiki Journal
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Name
Cocaethylene
Unit
mg
Description
Cocaethylene Source: SubstanceSearch (substancesearch.com) Endogenous Formation dose: threshold Not applicable - cocaethylene is formed endogenously in the liver when cocaine and alcohol are consumed together Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute tolerance; longer for full reset
Tolerance Decay
Full tolerance
1d
Half tolerance
10d
Baseline
~18d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Positive
- Increased energy
- Stimulation
- Physical euphoria
- Pain relief
Negative
- Cardiovascular stimulation
- Increased heart rate
- Nausea
- Pupil dilation
- Abnormal heartbeat
- Sedation
Positive
- Enhanced euphoria
- Increased confidence
- Increased sociability
- Cognitive euphoria
Negative
- Anxiety
- Paranoia
- Dizziness
- Reduced inhibition
- Time distortion
- Increased risk-taking behavior
Positive
- Increased libido
- Auditory enhancement
Negative
- Light sensitivity
- Appetite suppression
- Drifting
- Internal hallucination
- Auditory hallucinations
- Internal hallucinations
- Perception of increased weight
- Auditory distortion
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Bluelight 1 thread 1 neutral visit
Cocaethylene's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Cocaethylene? Let us know. Reports are reviewed by moderators — this is not posted publicly.