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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Coluracetam

    Aliases: Bci-540, Mkc-231

    Stimulant Nootropic Research-chemical

    Summary PsychonautWiki

    Coluracetam (BCI-540; formerly MKC-231) is a nootropic belonging to the racetam family of drugs. It was originally developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer's disease. After the drug had failed to reach the endpoints in its clinical trials, it was in-licensed by BrainCells Inc for investigations into major depressive disorder (MDD), which was preceded by being awarded a "Qualifying Therapeutic Discovery Program Grant" by the state of California.

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 3-5mg 5-10mg 10-20mg 20mg+
    Sublingual 2-5mg 5-10mg 10mg 10mg+
    Insufflated 2-5mg 5-10mg 10-20mg 20mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Peak Offset After Effects Total
    Oral 15-30 min 1-2 hrs 3-5 hrs 1-6 hrs 4.2-7.5 hrs
    Sublingual 1-5 min 1-2 hrs 3-5 hrs 1-6 hrs 4-7.1 hrs
    Insufflated 0-6 min - - 1-4 hours 0-6 min

    Effect Profile

    1 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 6.8
    Strong+ 7/10

    Strong focus and stimulation with low euphoria and anxiety/jitters

    Stimulation / Energy ×3
    8
    stimulation stamina enhancement wakefulness mild stimulation
    Euphoria / Mood Lift ×2
    2
    motivation enhancement
    Focus / Productivity ×2
    9
    focus enhancement analysis enhancement memory enhancement motivation enhancement
    ⚠ Anxiety / Jitters ×1
    2
    increased heart rate
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Coluracetam
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute tolerance; longer for full reset

    Tolerance Decay

    Full tolerance 3d Half tolerance 7d Baseline ~14d

    Tolerance patterns are based on community reports (no controlled human data). Many users report diminishing returns with daily use and prefer spacing doses to a few days per week. Cross‑tolerance between racetams is plausible but unquantified.

    Cross-Tolerances

    Other racetams
    20%

    Effects TheDrug.Wiki TripSit

    Positive
    • Stimulation
    • Stamina enhancement
    • Mild stimulation
    • Creativity enhancement
    Negative
    • Increased heart rate
    • Headaches
    • Insomnia
    • Headache
    • Motor impairment
    Neutral
    • Sedation
    Positive
    • Memory enhancement
    • Motivation enhancement
    • Thought connectivity
    • Anxiety suppression
    • Dream potentiation
    • Focus enhancement
    • Mindfulness
    • Wakefulness
    • Analysis enhancement
    Negative
    • Irritability
    Positive
    • Color enhancement
    • Visual acuity enhancement
    • Auditory acuity enhancement
    • Acuity enhancement
    • Auditory enhancement
    • Colour enhancement
    • Tactile enhancement
    • Music enhancement
    Negative
    • Light sensitivity
    Neutral
    • Dulled perception
    Coluracetam's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki 📖 TripSit