Coluracetam
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 4 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- PubChem toxicity data
- classified Research-chemical
- 4 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- PubChem toxicity data
- classified Research-chemical
Aliases: Bci-540, Mkc-231
Summary
Coluracetam (BCI-540; formerly MKC-231) is a nootropic belonging to the racetam family of drugs. It was originally developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer's disease. After the drug had failed to reach the endpoints in its clinical trials, it was in-licensed by BrainCells Inc for investigations into major depressive disorder (MDD), which was preceded by being awarded a "Qualifying Therapeutic Discovery Program Grant" by the state of California.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 3-5mg | 5-10mg | 10-20mg | 20mg+ |
| Sublingual | 2-5mg | 5-10mg | 10mg | 10mg+ |
| Insufflated | 2-5mg | 5-10mg | 10-20mg | 20mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 15-30 min | 1-2 hrs | 3-5 hrs | 3-6 hrs |
| Sublingual | 1-5 min | 1-2 hrs | 3-5 hrs | 3-6 hrs |
| Insufflated | 0-6 min | - | - | 0-6 min |
Effect Profile
1 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong focus and stimulation with low euphoria and anxiety/jitters
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Tolerance patterns are based on community reports (no controlled human data). Many users report diminishing returns with daily use and prefer spacing doses to a few days per week. Cross‑tolerance between racetams is plausible but unquantified.
Cross-Tolerances
Effects
- Stimulation
- Stamina enhancement
- Mild stimulation
- Creativity enhancement
- Increased heart rate
- Headaches
- Insomnia
- Headache
- Motor impairment
- Sedation
- Memory enhancement
- Motivation enhancement
- Thought connectivity
- Anxiety suppression
- Dream potentiation
- Focus enhancement
- Mindfulness
- Wakefulness
- Analysis enhancement
- Irritability
- Color enhancement
- Visual acuity enhancement
- Auditory acuity enhancement
- Acuity enhancement
- Auditory enhancement
- Colour enhancement
- Tactile enhancement
- Music enhancement
- Light sensitivity
- Dulled perception
Helpful Links
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