Etoxadrol
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Cl-1848c, U-37862a
Summary
Etoxadrol is a dioxolane NMDA antagonist developed as a dissociative anesthetic; unlike arylcyclohexylamines (PCP/ketamine), it features a 1,3-dioxolane piperidine scaffold. Clinical work shows IV 0.75 mg/kg yields anesthesia averaging 26 minutes (14-53 minutes) with active airway reflexes but raised heart rate/blood pressure and tachypnea. Prominent post-dose phenomena include alternating nystagmus lasting hours and vivid dream-like states; approximately 20% of patients reported unpleasant or threatening dreams persisting up to 24 hours.
Dose Information
No curated dose ladder is available for this substance. The figures below are drawn from SubstanceIndex (DoseWiki) as a fallback — often a conservative threshold only. Treat them as approximate and cross-reference before use.
Dose basis. Human dosing derives from historical clinical studies using intravenous bolus in fully monitored operating-theatre conditions; not studied for non-medical use. Values below summarize anesthetic-range exposures observed in peer‑reviewed trials and should not be interpreted as advice to use outside medical settings. (Dose figures and this note are from Drugs.Wiki.)
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Intravenous | 0.3-0.5mg/kg | 0.6-0.9mg/kg | 1.0-1.5mg/kg | 2.0mg/kg+ |
Onset, Duration & After-effects
| ROA | Onset | Offset | Total |
|---|---|---|---|
| Intravenous | <1-1 min | 15-60 min | 26-61 min |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong dissociative depth with moderate motor impairment, low mania and insight
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Etoxadrol there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Etoxadrol Source: SubstanceSearch (substancesearch.com) Intravenous dose (mg/kg): threshold 0.2 · light 0.3-0.5 · common 0.6-0.9 · strong 1.0-1.5 · heavy 2.0+ Intravenous duration: onset <1-1m · offset 0.25-1h · total 0.43-1.02h · after-effects 18-24h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 0.75 mg/kg (Intravenous).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Human tolerance data for etoxadrol are not available. Based on class effects with uncompetitive NMDA antagonists, tolerance often builds rapidly with repeated short‑interval use and partially decays over days to weeks; cross‑tolerance is expected across NMDA channel blockers. Data quality is low and inferred from related agents.
Cross-Tolerances
Effects
- Analgesia
- Stimulation
- Physical euphoria
- Stamina enhancement
- Creativity enhancement
- Nystagmus
- Tachycardia
- Nausea
- Numbness
- Loss of balance
- Cognitive euphoria
- Amnesia
- Depersonalization
- Confusion
- Anxiety
- Derealization
- Motor control loss
- Memory suppression
- Dissociation
- Time distortion
- Perception of bodily lightness
- Bodily control enhancement
- Visual acuity enhancement
- Tactile suppression
- Derealization
- Dream-like imagery
- After images
- Drifting
- Environmental cubism
- Environmental orbism
Combinations
Cross-Check Etoxadrol with another substanceHelpful Links
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