Etoxadrol
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 1 source
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Cl-1848c, U-37862a
Summary
Etoxadrol is a dioxolane NMDA antagonist developed as a dissociative anesthetic; unlike arylcyclohexylamines (PCP/ketamine), it features a 1,3-dioxolane piperidine scaffold. Clinical work shows IV 0.75 mg/kg yields anesthesia averaging 26 minutes (14-53 minutes) with active airway reflexes but raised heart rate/blood pressure and tachypnea. Prominent post-dose phenomena include alternating nystagmus lasting hours and vivid dream-like states; approximately 20% of patients reported unpleasant or threatening dreams persisting up to 24 hours.
Dose Information
No curated dose ladder is available for this substance. The figures below are drawn from SubstanceIndex (DoseWiki) as a fallback — often a conservative threshold only. Treat them as approximate and cross-reference before use.
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Intravenous | 0.3-0.5mg/kg | 0.6-0.9mg/kg | 1.0-1.5mg/kg | 2.0mg/kg+ |
Onset, Duration & After-effects
| ROA | Onset | Offset | Total |
|---|---|---|---|
| Intravenous | 1 min | 15-60 min | 26 min |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong dissociative depth with moderate motor impairment, low mania and insight
Tolerance
Tolerance Decay
Human tolerance data for etoxadrol are not available. Based on class effects with uncompetitive NMDA antagonists, tolerance often builds rapidly with repeated short‑interval use and partially decays over days to weeks; cross‑tolerance is expected across NMDA channel blockers. Data quality is low and inferred from related agents.
Cross-Tolerances
Effects
- Analgesia
- Stimulation
- Physical euphoria
- Stamina enhancement
- Creativity enhancement
- Nystagmus
- Tachycardia
- Nausea
- Numbness
- Loss of balance
- Cognitive euphoria
- Amnesia
- Depersonalization
- Confusion
- Anxiety
- Derealization
- Motor control loss
- Memory suppression
- Dissociation
- Time distortion
- Perception of bodily lightness
- Bodily control enhancement
- Visual acuity enhancement
- Tactile suppression
- Derealization
- Dream-like imagery
- After images
- Drifting
- Environmental cubism
- Environmental orbism
Combinations
Cross-Check Etoxadrol with another substanceHelpful Links
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Etoxadrol? Let us know. Reports are reviewed by moderators — this is not posted publicly.