Summary
Cyclobenzaprine is primarily prescribed as a short-term adjunct (2-3 weeks maximum) to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions. It is not effective for muscle spasm due to central nervous system disease. Overdose can cause anticholinergic toxicity including delirium, tachycardia, dry mouth, and urinary retention. There is risk of serotonin syndrome when combined with serotonergic drugs. Use with caution in elderly patients due to increased risk of confusion, cognitive impairment, and cardiac events.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 2-5mg | 5-10mg | 10-15mg | 15mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 30-60 min | 45-90 min | 2-4 hrs | 6-12 hrs | 24 hrs | 360-0 min |
Tolerance
Build-up
develops over 1–4 weeks of regular use
Reset
days to weeks depending on duration of use
Effects
Positive
- Muscle relaxation
- Physical euphoria
- Increased alertness
- Physical Euphoria
Negative
- Motor impairment
- Restlessness
- Insomnia
- Dry mouth
- Increased heart rate
- Sedation
Positive
- Cognitive euphoria
- Wakefulness
- Focus enhancement
Negative
- Drowsiness
- Motor control loss
- Dizziness
- Confusion
- Analysis suppression
- Anxiety
- Time distortion
Positive
Negative
- Appetite suppression
- Light sensitivity
- Disinhibition
- Acuity suppression
- Decreased Libido
- Acuity Suppression
- Visual acuity suppression
- Dulled perception
- Internal Hallucination
- Perception of bodily heaviness