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    Flubromazepam molecular structure

    Flubromazepam Stats & Data

    NPS DataHub
    MW333.16
    FormulaC15H10BrFN2O
    CAS2647-50-9
    IUPAC7-Bromo-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one
    SMILESO=C1CN=C(c2ccccc2F)c2cc(Br)ccc2N1
    InChIKeyZRKDDZBVSZLOFS-UHFFFAOYSA-N
    Benzodiazepines; 2020/3. Benzodiazepine; 2021/3. Benzodiazepine; 2022/3. Benzodiazepine
    Chemical Class Benzodiazepine
    Psychoactive Class Depressant
    Half-Life Very long; user reports and case discussions suggest on the order of days (~100 h), with substantial interindividual variability; formal human PK data are scarce.

    Interaction Warnings

    dissociatives

    This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.

    stimulants

    It is dangerous to combine benzodiazepines with stimulants due to the risk of excessive intoxication. Stimulants decrease the sedative effect of benzodiazepines, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of benzodiazepines will be significantly increased, leading to intensified disinhibition as well as other effects.

    Receptor Profile

    Receptor Actions

    Modulators
    GABA-A receptor positive allosteric modulator (benzodiazepine site)
    Other
    Voltage-gated sodium channel blocker (anticonvulsant mechanism)

    History & Culture

    Flubromazepam is a benzodiazepine derivative first synthesized in 1960. Despite being developed during a period of active benzodiazepine research that produced many compounds which would eventually reach clinical use, flubromazepam was never marketed and received no further scientific attention for over fifty years. The compound reemerged in late 2012 when it appeared on the grey market as a novel designer drug. Since then, it has been sold primarily through online research chemical vendors for recreational use and has not undergone formal clinical study. An alternate structural isomer, sometimes referred to as "iso-flubromazepam," has reportedly been sold under the same name during this period.

    Subjective Effect Notes

    physical: The physical effects of flubromazepam can be broken down into several components which progressively intensify proportional to dosage.

    cognitive: The cognitive effects of flubromazepam can be broken down into several components which progressively intensify proportional to dosage. The general head space of flubromazepam is described by many as one of intense sedation and decreased inhibition. It contains a large number of typical depressant cognitive effects.

    Effect Profile

    Curated + 4 Reports
    Benzodiazepine 7.1

    Strong anxiolysis, cognitive impairment, and euphoria with mild sedation

    Anxiolysis×3
    10
    Sedation / Relaxation×2
    5
    Motor / Cognitive Impairment×1
    10
    Euphoria / Mood Lift×1
    10

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Very long; user reports and case discussions suggest on the order of days (~100 h), with substantial interindividual variability; formal human PK data are scarce.
    Addiction Potential
    High, comparable to other benzodiazepines; dependence and severe withdrawal (including seizures) are risks with regular or high-dose use.

    Tolerance Decay

    Full tolerance 14d Half tolerance 14d Baseline ~28d

    Rapid functional tolerance develops with repeated use, as with other GABA-A positive allosteric modulators; recovery is slow. Model parameters are approximate and intended for harm-reduction planning (spacing doses by several days); individual variability is high. Data quality largely anecdotal.

    Cross-Tolerances

    Other benzodiazepines
    80% ●●○
    Z-drugs (zolpidem, zopiclone)
    40% ●○○
    Alcohol (GABAergic effects)
    30% ●○○

    Experience Report Analysis

    Erowid
    4 Reports
    2012–2022 Date Range
    4 With Age Data
    2 Effects Detected

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Effect Analysis

    Erowid

    Effects aggregated from 4 experience reports (4 Erowid)

    4 Reports
    2 Effects Detected
    1 Positive
    1 Adverse
    0 Neutral

    Effect Sentiment Distribution

    Confidence Distribution

    Positive Effects 1

    Euphoria 75.0% 70%

    Adverse Effects 1

    Memory Suppression 75.0% 70%

    Real-World Dose Distribution

    62K Doses

    From 4 individual dose entries

    Form / Preparation

    Most common forms and preparations reported

    Benzodiazepine Equivalence

    8.0 mg Flubromazepam = 10.0 mg Diazepam
    Potency ratio 1.25

    Flubromazepam - 6-8mg ~=10mg Diazepam.

    Legal Status

    Country Status Notes
    Canada Schedule IV CDSA Controlled as a benzodiazepine under Schedule IV of the Controlled Drugs and Substances Act.
    Germany Anlage II BtMG Listed in Anlage II of the Betäubungsmittelgesetz (Narcotics Act) since November 21, 2015. Manufacturing, possession, import, export, purchase, sale, procurement, and dispensing are prohibited without a license.
    Russia Schedule III Classified as a Schedule III controlled substance since 2017.
    Switzerland Verzeichnis E Specifically named as a controlled substance under Verzeichnis E of Swiss narcotics regulations.
    Turkey Controlled Classified as a controlled drug under national legislation. Possession, production, supply, and importation are illegal.
    United Kingdom Class C Controlled under the Misuse of Drugs Act 1971 as of May 31, 2017. Possession, production, and supply are prohibited.
    United States Unscheduled (Federal); Schedule I (Virginia) No federal scheduling under the Controlled Substances Act. Virginia has independently classified flubromazepam as a Schedule I controlled substance under state law.

    Harm Reduction

    drugs.wiki

    Identity confusion and mislabeling have occurred: two positional isomers (“flubromazepam” vs “iso-flubromazepam”) have circulated; use drug checking where possible and avoid assuming pellets/tablets contain accurate doses. The long and variable half-life promotes accumulation—space doses by multiple days and avoid redosing during the same session to prevent unintended multi-day intoxication. Delayed onset (often ≥60 minutes) increases redose temptation; plan a fixed single dose and wait. Strong sedation, psychomotor impairment, anterograde amnesia, and next-day ‘hangover’ are commonly reported—do not drive, cycle, swim, or operate machinery for at least 24 hours after dosing (longer after high doses). Combining with other depressants—especially opioids, alcohol, GHB/GBL or tramadol—markedly increases risk of respiratory depression and fatal overdose; avoid these combinations. If physically dependent, do not abruptly stop: benzodiazepine withdrawal can be severe or life-threatening; taper gradually with clinical guidance. Avoid insufflation or injection: poor solubility and binders increase harm with no benefit; if using powder, prepare a measured solution (e.g., in propylene glycol/ethanol) for volumetric dosing to improve accuracy. Consider pregnancy and neonatal risks: benzodiazepines cross the placenta and may cause neonatal withdrawal; seek medical advice. Given frequent counterfeit/overdosed tablets in the market, prefer known-concentration solutions and send suspect samples to a lab drug-checking service when feasible.

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