Flumazenil
Aliases: Anexate, Lanexat, Mazicon, Romazicon, Ro 15-1788
Summary
Flumazenil is the benzodiazepine antidote and can abruptly trigger withdrawal or seizures in dependent individuals. It should only be used with seizure management on standby and careful screening for mixed overdoses. Flumazenil competitively blocks the benzodiazepine site on the GABAA receptor.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset |
|---|---|---|---|
| Intravenous (Bolus) | 1-2 min | 6-10 min | 1-2 hrs |
| Intranasal (Investigational / Pediatric) | 5-8 min | 10-20 min | 1-2 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Benzodiazepine
3.6
Moderate
4/10
Low anxiolysis and sedation
Anxiolysis
×3
3
reduced anxiety
Sedation / Relaxation
×2
3
sedation
Motor / Cognitive Impairment
×1
0
Euphoria / Mood Lift
×1
0
Based on reports from:
Tolerance
Build-up
develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
Reset
weeks to months depending on half-life and duration of use; taper recommended
Tolerance Decay
Full tolerance
3d
Half tolerance
37d
Baseline
~60d
Effects
Negative
- Nausea or vomiting
- Tremor
- Motor impairment
- Sedation
Positive
- Reduced anxiety
Negative
- Anxiety or panic
- Dysphoria
- Dizziness
- Abrupt return of consciousness
Neutral
- Dulled perception
Combinations
Flumazenil's nerd page
Pharmacology, chemical data, effect profiles, and more
→