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    Disclaimer
    ๐Ÿงช This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    โš  Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    GABOB

    Aliases: Buxamine, Buxamina, ฮ’-hydroxy-gaba, 3-hydroxy-gaba

    Depressant Nootropic Research-chemical Opioid

    Summary TheDrug.Wiki

    Oral bioavailability is relatively low; commercial Gamalate B6 contains only 37.5 mg GABOB per tablet (standard therapeutic dose: 225 mg/day via 6 tablets). Recreational users resort to bulk powder or rectal administration. Weak potency and high inter-individual variability reported; one Bluelight user found 1 g rectally essentially without effect.

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset After Effects
    Oral 20-60 min 1-2 hrs 1-2 hrs 1-4 hrs
    Rectal 10-30 min 1-2 hrs 1-2 hrs 1-4 hrs

    Effect Profile

    2 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 3.3
    Light+ 3/10

    Strong sedation with mild itching/nausea, low euphoria

    Euphoria / Warmth ×3
    3
    physical euphoria
    Analgesia ×2
    0
    Sedation / Relaxation ×1
    8
    sedation sleep enhancement muscle relaxation
    ⚠ Itching / Nausea ×1
    4
    nausea
    Based on reports from:
    Erowid Experience Reports PsychonautWiki GABOB
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7โ€“14 days for partial reset; full reset may take weeks โ€” tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 1d Half tolerance 21d Baseline ~35d

    Effects TheDrug.Wiki

    Positive
    • Anxiolysis
    • Muscle Relaxation
    • Sleep Enhancement
    • Muscle relaxation
    • Stimulation
    • Physical euphoria
    Negative
    • Motor impairment
    • Increased heart rate
    • Nausea
    Neutral
    • Sedation
    Positive
    • Cognitive Enhancement
    • Reduced anxiety
    • Anxiety suppression
    • Focus enhancement
    • Motivation enhancement
    • Memory enhancement
    • Analysis enhancement
    • Mindfulness
    Negative
    • Motor control loss
    Neutral
    • Thought organization
    Positive
    • Appetite Enhancement
    • Increased libido
    • Increased music appreciation
    • Appetite enhancement
    Negative
    • Light sensitivity
    • Disinhibition
    • Double vision
    • Dehydration
    Neutral
    • Dulled perception
    • Optical sliding

    Combinations TripSit

    GABOB's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    ๐Ÿ“˜ Experience Reports ๐Ÿ“– TheDrug.Wiki ๐Ÿ“– PsychonautWiki