GABOB
Aliases: Buxamine, Buxamina, ฮ-hydroxy-gaba, 3-hydroxy-gaba
Categories
Summary
Oral bioavailability is relatively low; commercial Gamalate B6 contains only 37.5 mg GABOB per tablet (standard therapeutic dose: 225 mg/day via 6 tablets). Recreational users resort to bulk powder or rectal administration. Weak potency and high inter-individual variability reported; one Bluelight user found 1 g rectally essentially without effect. Racemic mixtures display stereoselectivity: (R)-GABOB shows moderate GABA-B agonism, while (S)-GABOB is both a partial GABA-B agonist and full GABA-A agonist, making it twice as potent as an anticonvulsant. Standard harm reduction: titrate with 300 mg or less initially, avoid mixing with depressants, and store powder in desiccated containers as it is hygroscopic.
Dose Information
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Oral | 20-60 min | 1-2 hrs | 1-2 hrs | 1-4 hrs |
| Rectal | 10-30 min | 1-2 hrs | 1-2 hrs | 1-4 hrs |
Tolerance
Effects
- Anxiolysis
- Muscle Relaxation
- Sleep Enhancement
- Muscle relaxation
- Stimulation
- Physical euphoria
- Motor impairment
- Increased heart rate
- Nausea
- Sedation
- Cognitive Enhancement
- Reduced anxiety
- Anxiety suppression
- Focus enhancement
- Motivation enhancement
- Memory enhancement
- Analysis enhancement
- Mindfulness
- Motor control loss
- Thought organization
- Appetite Enhancement
- Increased libido
- Increased music appreciation
- Appetite enhancement
- Light sensitivity
- Disinhibition
- Double vision
- Dehydration
- Dulled perception
- Optical sliding