Yesterday I decided to try taking the GHB analogue GABOB (gamma-amino-beta-hydroxy-butyric acid ) again. I had tried it previously while I was experimenting with massive amounts of GHB, GBL, 4-Methyl-GHB, GVL, etc. without much success.
GABOB
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Buxamine, Buxamina, ฮ-hydroxy-gaba, 3-hydroxy-gaba
Summary
Oral bioavailability is relatively low; commercial Gamalate B6 contains only 37.5 mg GABOB per tablet (standard therapeutic dose: 225 mg/day via 6 tablets). Recreational users resort to bulk powder or rectal administration. Weak potency and high inter-individual variability reported; one Bluelight user found 1 g rectally essentially without effect.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset |
|---|---|---|---|
| Oral | 20-60 min | 1-2 hrs | 1-2 hrs |
| Rectal | 10-30 min | 1-2 hrs | 1-2 hrs |
Effect Profile
2 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
3.3
Light+
3/10
Strong sedation with mild itching/nausea, low euphoria
Euphoria / Warmth
×3
3
physical euphoria
Analgesia
×2
0
Sedation / Relaxation
×1
8
sedation
sleep enhancement
muscle relaxation
Itching / Nausea
×1
4
nausea
Based on reports from:
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7โ14 days for partial reset; full reset may take weeks โ tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
1d
Half tolerance
21d
Baseline
~35d
Acute tolerance: develops within a single session โ the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Positive
- Anxiolysis
- Muscle Relaxation
- Sleep Enhancement
- Muscle relaxation
- Stimulation
- Physical euphoria
Negative
- Motor impairment
- Increased heart rate
- Nausea
- Sedation
Positive
- Cognitive Enhancement
- Reduced anxiety
- Anxiety suppression
- Focus enhancement
- Motivation enhancement
- Memory enhancement
- Analysis enhancement
- Mindfulness
Negative
- Motor control loss
- Thought organization
Positive
- Appetite Enhancement
- Increased libido
- Increased music appreciation
- Appetite enhancement
Negative
- Light sensitivity
- Disinhibition
- Double vision
- Dehydration
- Dulled perception
- Optical sliding
Combinations
Cross-Check GABOB with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 1 report 1 neutral visit
GABOB's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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