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    Disclaimer
    ๐Ÿงช This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    โš  Benzodiazepines can cause physical dependence with regular use. Withdrawal can be life-threatening. Never combine with opioids or alcohol.
    โš  Deliriants can cause frightening, uncontrollable hallucinations and dangerous behavior. Medical emergencies are common at higher doses.

    Gaboxadol

    Aliases: Thip, Ov101, Mk-0928, Lu-2-030, Lu-02-030

    Depressant Deliriant Research-chemical Benzodiazepine

    Summary TheDrug.Wiki PsychonautWiki

    Gaboxadol (THIP) is a direct-acting GABA-A receptor agonist developed by Lundbeck and Merck as an experimental sleep aid. Clinical trials were discontinued in 2007 due to narrow therapeutic index and psychiatric side effects at effective doses. Unlike benzodiazepines, it acts as an orthosteric agonist at the GABA binding site with preferential activity at extrasynaptic ฮด subunit-containing receptors.

    Dose Information TheDrug.Wiki PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 10-15mg 15-30mg 30-45mg 45mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects
    Oral 15-60 min 30-60 min 1-3 hrs 2-4 hrs 1-6 hrs

    Effect Profile

    2 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Benzodiazepine 4.3
    Moderate 4/10

    Strong cognitive impairment with mild anxiolysis, sedation, and euphoria

    Anxiolysis ×3
    5
    anxiolysis muscle relaxation
    Sedation / Relaxation ×2
    5
    sedation muscle relaxation
    ⚠ Motor / Cognitive Impairment ×1
    9
    motor control loss ataxia memory suppression confusion
    Euphoria / Mood Lift ×1
    4
    cognitive euphoria
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Gaboxadol
    View methodology →

    Tolerance

    Build-up develops over 1โ€“4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
    Reset weeks to months depending on half-life and duration of use; taper recommended

    Tolerance Decay

    Full tolerance 3d Half tolerance 7d Baseline ~14d

    Evidence on tolerance kinetics in humans is sparse. Rapid tolerance is expected with daily use by analogy to other GABAergic sedatives; some animal data suggest distinct receptor populations (extrasynaptic ฮด vs. synaptic ฮณ2) which may alter cross-tolerance magnitude relative to benzodiazepines.

    Cross-Tolerances

    Benzodiazepines (GABA-A positive allosteric modulators)
    30%
    Barbiturates
    30%
    Z-drugs (zolpidem, zopiclone)
    30%

    Effects TheDrug.Wiki

    Positive
    • Muscle relaxation
    • Anxiolysis
    • Pain relief
    Negative
    • Nausea
    • Ataxia
    • Muscle twitching
    Neutral
    • Sedation
    • Sleepiness
    • Muscle twitches
    • Increased salivation
    Positive
    • Cognitive euphoria
    • Dream potentiation
    • Empathy enhancement
    Negative
    • Memory suppression
    • Dizziness
    • Motor control loss
    • Delirium
    • Confusion
    Neutral
    • Perspective distortions
    • Consciousness disconnection
    Positive
    • Colour shifting
    • Increased music appreciation
    Neutral
    • Auditory hallucinations
    • External hallucinations
    • Internal hallucinations
    • Visual distortions
    • Drifting
    • External hallucination
    • Internal hallucination
    • Spontaneous physical sensations

    Combinations TripSit

    Trip Reports Effect Index

    Gaboxadol's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    ๐Ÿ“˜ Experience Reports ๐Ÿ“– TheDrug.Wiki ๐Ÿ“– PsychonautWiki