Grapefruit
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
- partial dose data
- duration data present
- dose data not in PW/TripSit (unverifiable)
- 1 source
- partial dose data
- duration data present
- dose data not in PW/TripSit (unverifiable)
Aliases: Pomelo, Forbidden fruit
Summary
Bergamottin and 6',7'-dihydroxybergamottin in grapefruit irreversibly inactivate intestinal CYP3A4 via mechanism-based covalent binding, reducing enzyme abundance by 50-70% after a single 200 ml serving. Full resynthesis takes 24-72 hours, meaning timing separation of grapefruit and medication does not prevent interactions. Parallel inhibition of intestinal P-glycoprotein raises systemic exposure to many substrates, while OATP1A2 blockade can paradoxically lower absorption of drugs like fexofenadine.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 100-200ml | - | - | - |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 15-30 min | 30-60 min | 30 min | 24 hrs | 25.25-26 hrs |
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Grapefruit there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Grapefruit Source: SubstanceSearch (substancesearch.com) Oral dose (ml): threshold 50 · light 100-200 Oral duration: onset 15-30m · come-up 0.5-1h · peak 30m · offset 24h · total 25.25-26h · after-effects 24-72h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
- Mild digestive stimulation
- Bitter-sweet citrus flavor
Helpful Links
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