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    L-Tryptophan

    Aliases: 5-htp, Oxyfan, Telesol, Triptum, Levothym, 5htp, 5-hydroxytryptophan, tryptophan, oxitriptan

    Nootropic Supplement Opioid

    Summary Erowid TripSit PsychonautWiki

    L-Tryptophan is an essential amino acid, meaning the human body does not produce it naturally, but is required for the body's healthy functioning. L-Tryptophan is present in a wide range of foods including beans, nuts, milk, and poultry. L-Tryptophan is a precursor to 5-HTP (which is a precursor to serotonin) and is sold as a sleep aid and mood enhancer.

    Dose Information TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 50-100mg 100-300mg 300-500mg 500mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TripSit PsychonautWiki

    ROA Onset Peak Total
    Oral 30-60 min 4-6 hrs 4.5-7 hrs

    Effect Profile

    101 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 101 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 3.9
    Moderate 4/10

    Strong itching/nausea and sedation with moderate euphoria

    Euphoria / Warmth ×3
    6
    cognitive euphoria
    Analgesia ×2
    0
    Sedation / Relaxation ×1
    8
    sedation dream potentiation
    ⚠ Itching / Nausea ×1
    9
    nausea
    Based on reports from:
    Erowid Experience Reports PsychonautWiki L-Tryptophan
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 1d Half tolerance 21d Baseline ~35d

    Effects Erowid

    Aggregated from 101 Erowid experience reports

    Positive Effects 12

    Anxiety Suppression 38.6% 70%
    Stimulation 33.7% 70%
    Euphoria 32.7% 70%
    Sedation 32.7% 70%
    Tactile Enhancement 21.8% 70%
    Color Enhancement 19.8% 70%
    Empathy 19.8% 70%
    Music Enhancement 16.8% 70%
    Focus Enhancement 16.8% 70%
    Body High 9.9% 70%
    Introspection 8.9% 70%
    Creativity Enhancement 4.0% 70%

    Adverse Effects 10

    Nausea 29.7% 70%
    Confusion 19.8% 70%
    Sweating 11.9% 70%
    Headache 7.9% 70%
    Increased Heart Rate 7.9% 70%
    Memory Suppression 7.9% 70%
    Jaw Clenching 6.9% 70%
    Muscle Tension 5.9% 70%
    Motor Impairment 5.0% 70%
    Seizure 3.0% 70%

    Combinations TripSit

    L-Tryptophan's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

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