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    Meclofenoxate

    Aliases: Anp 235, Acephen, Lucidril, Helfergin, Centrophenoxine

    Stimulant Nootropic

    Summary TheDrug.Wiki Erowid TripSit PsychonautWiki

    Meclofenoxate is not FDA-approved in the United States but is sold as a dietary supplement; it is a prescription medication in some countries including Japan and parts of Europe. Individuals with depression, mania, epilepsy, or convulsive disorders should avoid use entirely. The substance is prohibited for athletes under WADA regulations as a stimulant.

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 50-200mg 400-800mg 800-1000mg 600mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Peak Offset After Effects Total
    Oral 30-90 min 2-4 hrs 2-4 hrs 12-12 hrs 4.5-9.5 hrs

    Effect Profile

    1 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 5.5
    Strong 6/10

    Moderate stimulation and focus with mild anxiety/jitters, low euphoria

    Stimulation / Energy ×3
    7
    stimulation stamina enhancement wakefulness
    Euphoria / Mood Lift ×2
    2
    motivation enhancement
    Focus / Productivity ×2
    7
    focus enhancement memory enhancement motivation enhancement
    ⚠ Anxiety / Jitters ×1
    5
    increased heart rate teeth grinding
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Meclofenoxate
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute tolerance; longer for full reset

    Tolerance Decay

    Full tolerance 1d Half tolerance 10d Baseline ~18d

    Effects TheDrug.Wiki

    Positive
    • Stamina Enhancement
    • Stimulation
    • Subtle Stimulation
    Negative
    • Increased heart rate
    • Headaches
    • Fatigue
    • Headache
    • Teeth grinding
    Neutral
    • Gastrointestinal Distress
    • Body odor alteration
    Positive
    • Focus Enhancement
    • Memory Enhancement
    • Wakefulness
    • Motivation Enhancement
    • Dream Potentiation
    • Mindfulness
    • Thought Connectivity
    • Anxiety Suppression
    • Addiction Suppression
    Neutral
    • Focus intensification
    Positive
    • Bodily Control Enhancement
    • Visual Acuity Enhancement
    • Acuity Enhancement
    • Auditory Acuity Enhancement
    • Color Enhancement
    Negative
    • Light sensitivity
    • Appetite Suppression
    • Appetite suppression
    • Dehydration
    Neutral
    • Olfactory Intensification
    Meclofenoxate's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

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