Methaqualone
Aliases: 714s, Sopor, Ludes, Quack, Parest, quaaludes, qualudes, mandrax
Summary
Methaqualone (brand name Quaalude in the US and Mandrax in the UK) is a central nervous system (CNS) depressant of the quinazolinone class that acts as a sedative and hypnotic. The sedative–hypnotic activity of methaqualone was first noted by researchers in the 1950s and in 1962 methaqualone itself was patented in the US by Wallace and Tiernan. Its use peaked in the early 1970s as a hypnotic, for the treatment of insomnia, and as a sedative and muscle relaxant.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 150-300mg | 300-500mg | 500-600mg | 300mg+ |
| Smoked | 50-100mg | 100-200mg | 200-300mg | 300mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 20-45 min | 30-60 min | 2-4 hrs | 2-4 hrs | 4.8-9.8 hrs |
| Smoked | 30-45 minutes | - | - | - | 60-120 minutes |
Tolerance
Tolerance Decay
Erowid documents rapid tolerance; tolerance to euphoria rises faster than to respiratory depression, increasing overdose risk when escalating doses. Spacing doses by several days to a week is prudent. Estimates above are approximate and based on HR consensus/user reports, not controlled studies.
Cross-Tolerances
Effects
Aggregated from 21 Erowid experience reports