N-Acetylcysteine
Aliases: Nac, Acetylcysteine
Summary
N-Acetylcysteine (NAC), also known as Acetylcysteine, is a medication that is used to treat paracetamol (acetaminophen) overdose, and to loosen thick mucus in individuals with chronic bronchopulmonary disorders like pneumonia, bronchitis and cystic fibrosis. It has been used to treat lactobezoar in infants. It can be taken intravenously, by mouth, or inhaled as a mist.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 400-600mg | 600-1000mg | 1000-1500mg | 1500mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 20-60 min | 1-3 hrs | 2-4 hrs | 3.3-8 hrs |
Tolerance
Build-up
varies by mechanism; therapeutic tolerance may develop over weeks of regular use
Reset
typically days to weeks after discontinuation
Tolerance Decay
Full tolerance
3d
Half tolerance
8d
Baseline
~14d
Effects
Positive
- Bronchodilation
- Cough Suppression
- Stimulation
Negative
- Nausea
- Headaches
- Increased Blood Pressure
- Increased heart rate
- Headache
- Itchiness
- Sedation
Positive
- Addiction Suppression
- Anxiety Suppression
- Focus Enhancement
- Motivation Enhancement
- Mindfulness
- Cognitive Clarity
- Wakefulness
- Motivation enhancement
- Focus enhancement
Negative
- Anxiety
Positive
- Increased music appreciation
- Increased libido
- Increased Music Appreciation
- Color enhancement
Negative
- Appetite Suppression
- Dehydration
- Light sensitivity
- Appetite suppression
- Dulled perception
- Spontaneous physical sensations
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