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    Nicotine

    Aliases: Nic

    Stimulant Nootropic

    Summary TheDrug.Wiki Erowid TripSit PsychonautWiki

    Nicotine is a potent, highly addictive stimulant alkaloid found naturally in tobacco plants. While nicotine itself is not carcinogenic, tobacco smoke contains over 7,000 chemicals, including at least 250 known harmful substances. Overdose can cause severe nausea, vomiting, increased heart rate, convulsions, and in extreme cases death.

    Dose Information TheDrug.Wiki PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 1-3mg 3-5mg 5-7mg 7mg+
    Smoked 0.3-0.8mg 0.8-1.5mg 1.5-3.5mg 3.5mg+
    Sublingual 1-3mg 3-5mg 5-7mg 7mg+
    Buccal 0.5-2mg 2-4mg 4-6mg 6mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 20-40 min 60-90 min 60-90 min 2.5-3.5 hrs 2-4 hrs -
    Smoked 0-1 min - 2-5 min 1-2 hrs 1-3 hrs 1-2.1 hrs
    Sublingual 3-15 min 3-15 min 5-20 min 1-2 hrs 2-6 hrs -
    Buccal 6-12 min 6-12 min 6-18 min 1-2 hrs 2-6 hrs -

    Effect Profile

    41 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 41 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 8.4
    Intense 8/10

    Strong euphoria, focus, anxiety/jitters, and stimulation

    Stimulation / Energy ×3
    9
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    10
    physical euphoria cognitive euphoria motivation enhancement
    Focus / Productivity ×2
    10
    focus enhancement memory enhancement motivation enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    10
    anxiety increased heart rate teeth grinding vasoconstriction
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Nicotine
    View methodology →

    Tolerance

    Build-up develops rapidly within days of regular use
    Reset 2–4 weeks for acute tolerance; receptor upregulation persists longer

    Tolerance Decay

    Full tolerance 3d Half tolerance 14d Baseline ~30d

    Tolerance to stimulant and autonomic effects rises quickly with daily use and decays over weeks; values are approximate and inferred from dependence literature and user reports rather than controlled dosing studies.

    Cross-Tolerances

    Other nicotinic agonists (e.g., cytisinicline, varenicline partial agonism differs)
    30%

    Effects Erowid

    Aggregated from 41 Erowid experience reports

    Positive Effects 9

    Euphoria 51.2% 70%
    Stimulation 51.2% 70%
    Focus Enhancement 34.1% 70%
    Music Enhancement 31.7% 70%
    Empathy 29.3% 70%
    Color Enhancement 26.8% 70%
    Tactile Enhancement 12.2% 70%
    Introspection 9.8% 70%
    Body High 7.3% 70%

    Adverse Effects 4

    Anxiety 46.3% 70%
    Nausea 39.0% 70%
    Confusion 19.5% 70%
    Increased Heart Rate 7.3% 70%

    Combinations TripSit

    Nicotine's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

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