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    Nicotine

    Aliases: Nic

    Categories

    Stimulant Nootropic
    Nicotine structure

    Summary TheDrug.Wiki Erowid TripSit PsychonautWiki

    Nicotine is a potent, highly addictive stimulant alkaloid found naturally in tobacco plants. While nicotine itself is not carcinogenic, tobacco smoke contains over 7,000 chemicals, including at least 250 known harmful substances. Overdose can cause severe nausea, vomiting, increased heart rate, convulsions, and in extreme cases death. Chronic tobacco use is strongly associated with cardiovascular disease, cancer, and respiratory illness. Lethal dose is estimated at 6.5-13 mg/kg orally.

    Dose Information TheDrug.Wiki PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 1-3mg 3-5mg 5-7mg 7mg+
    Smoked 0.3-0.8mg 0.8-1.5mg 1.5-3.5mg 3.5mg+
    Sublingual 1-3mg 3-5mg 5-7mg 7mg+
    Buccal 0.5-2mg 2-4mg 4-6mg 6mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 20-40 min 60-90 min 60-90 min 2.5-3.5 hrs 2-4 hrs -
    Smoked 0-1 min 0-0 min 2-5 min 1-2 hrs 1-3 hrs 600-0 min
    Sublingual 3-15 min 3-15 min 5-20 min 1-2 hrs 2-6 hrs -
    Transdermal 15-30 min - - 1-2 hrs 1-2 hrs -
    Buccal 6-12 min 6-12 min 6-18 min 1-2 hrs 2-6 hrs -

    Tolerance

    Build-up develops rapidly within days of regular use
    Reset 2–4 weeks for acute tolerance; receptor upregulation persists longer

    Effects TheDrug.Wiki TripSit

    Positive
    • Stimulation
    • Physical euphoria
    Negative
    • Increased heart rate
    • Nausea
    • Increased perspiration
    • Abnormal heartbeat
    • Vasoconstriction
    • Teeth grinding
    • Headache
    Neutral
    • Sedation
    Positive
    • Anxiety suppression
    • Cognitive euphoria
    • Focus enhancement
    • Motivation enhancement
    • Wakefulness
    • Memory enhancement
    • Dream potentiation
    Negative
    • Dizziness
    • Compulsive redosing
    • Anxiety
    Neutral
    • Thought acceleration
    Positive
    • Increased music appreciation
    • Increased libido
    • Tactile enhancement
    Negative
    • Appetite suppression
    • Light sensitivity
    • Disinhibition
    • Dehydration
    Neutral
    • Increase sexuality
    • Visual and audiotory hallucinations itchiness
    • Auditory hallucination

    Combinations TripSit

    Helpful Links

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