Bought a bottle of Picamilon powder, 20 G, some time ago which was refrigerated until use and after checking out dosages. Recently tried 350 mg which is what I could stuff into a '00' capsule. The highest dosage I noted on the internet was 100 mg 3 times a day.
Picamilon
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 1 ROA with full dose ladder
- duration data present
- 16 combo interactions documented
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 1 ROA with full dose ladder
- duration data present
- 16 combo interactions documented
Summary
An analogue of GABA that does pass the brain blood barrier, which is then hydrolyzed into GABA and Niacin. In which the GABA could produce an anxiolytic effect. The Niacin as a vasodilator.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 40-80mg | 80-140mg | 140-250mg | 250mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Total |
|---|---|---|---|
| Oral | 10-45 min | 2-4 hrs | 2-4 hrs |
Tolerance
Build-up
develops over weeks of regular use via CB1 receptor downregulation
Reset
2–4 weeks for most users; heavy users may need longer
Tolerance Decay
Full tolerance
3d
Half tolerance
21d
Baseline
~28d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Positive
- Stimulation
- Physical euphoria
Negative
- Motor impairment
- Increased heart rate
- Nausea
- Headache
- Headaches
- Insomnia
- Vasoconstriction
- Sedation
Positive
- Reduced anxiety
- Wakefulness
- Motivation enhancement
- Focus enhancement
- Memory enhancement
- Anxiety suppression
- Cognitive euphoria
- Focus Enhancement
Negative
- Anxiety
- Irritability
Positive
- Increased music appreciation
- Increased libido
- Increased Music Appreciation
- Color enhancement
Negative
- Light sensitivity
- Appetite suppression
- Dehydration
- Appetite Suppression
- Dulled perception
- Spontaneous physical sensations
Combinations
Cross-Check Picamilon with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 1 report 1 neutral visit
Picamilon's nerd page
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Helpful Links
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