Picamilon
Summary
An analogue of GABA that does pass the brain blood barrier, which is then hydrolyzed into GABA and Niacin. In which the GABA could produce an anxiolytic effect. The Niacin as a vasodilator.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 40-80mg | 80-140mg | 140-250mg | 250mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Total |
|---|---|---|---|
| Oral | 10-45 min | 2-4 hrs | 2.2-4.8 hrs |
Tolerance
Build-up
develops over weeks of regular use via CB1 receptor downregulation
Reset
2–4 weeks for most users; heavy users may need longer
Tolerance Decay
Full tolerance
3d
Half tolerance
21d
Baseline
~28d
Effects
Positive
- Stimulation
- Physical euphoria
Negative
- Motor impairment
- Increased heart rate
- Nausea
- Headache
- Headaches
- Insomnia
- Vasoconstriction
- Sedation
Positive
- Reduced anxiety
- Wakefulness
- Motivation enhancement
- Focus enhancement
- Memory enhancement
- Anxiety suppression
- Cognitive euphoria
- Focus Enhancement
Negative
- Anxiety
- Irritability
Positive
- Increased music appreciation
- Increased libido
- Increased Music Appreciation
- Color enhancement
Negative
- Light sensitivity
- Appetite suppression
- Dehydration
- Appetite Suppression
- Dulled perception
- Spontaneous physical sensations
Combinations
Picamilon's nerd page
Pharmacology, chemical data, effect profiles, and more
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