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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Benzodiazepines can cause physical dependence with regular use. Withdrawal can be life-threatening. Never combine with opioids or alcohol.

    Pyrazolam

    Aliases: Sh-i-04

    Depressant Research-chemical Benzodiazepine

    Summary TheDrug.Wiki TripSit PsychonautWiki

    Pyrazolam is a novel depressant substance of the benzodiazepine class. Pyrazolam was originally developed at Hoffman-La Roche in the 1970s and subsequently "rediscovered" and sold as a research chemical starting in 2012. Subjective effects include sedation, anxiety suppression, muscle relaxation, disinhibition, and euphoria.

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 0.5-0.75mg 0.75-1.5mg 1.5-3mg 3mg+
    Light Common Strong Heavy

    Benzo Equivalence Calculator

    mg
    2.0 mg Pyrazolam
    =
    — mg Diazepam

    ⚠ These are approximate equivalences for educational and cross-tapering reference. Individual response, tolerance, and half-life differences mean actual equivalence varies. Always consult a healthcare provider for tapering guidance.

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Peak Offset After Effects Total
    Oral 10-15 min 1-3 hrs 4-6 hrs 1-12 hours 5.2-9.2 hrs

    Effect Profile

    9 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Benzodiazepine 6.9
    Strong+ 7/10

    Strong anxiolysis and cognitive impairment with moderate euphoria, mild sedation

    Anxiolysis ×3
    10
    anxiety suppression anxiolytic muscle relaxation muscle relaxant
    Sedation / Relaxation ×2
    5
    sedation muscle relaxation
    ⚠ Motor / Cognitive Impairment ×1
    8
    motor control loss amnesia delusions of sobriety double vision
    Euphoria / Mood Lift ×1
    6
    physical euphoria disinhibition
    Based on reports from:
    Effect Index Pyrazolam Erowid Experience Reports PsychonautWiki Pyrazolam The Drug Users Bible Pyrazolam
    View methodology →

    Tolerance

    Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
    Reset weeks to months depending on half-life and duration of use; taper recommended

    Tolerance Decay

    Full tolerance 3d Half tolerance 7d Baseline ~21d

    As with other benzodiazepines, tolerance to sedative/hypnotic effects can build within days of repeated dosing; anxiolytic tolerance may develop more gradually. Rough recovery to baseline often requires several weeks off. Estimates here are conservative and based on general benzo patterns and user reports, not controlled studies.

    Cross-Tolerances

    Other benzodiazepines
    80%
    Z-drugs (e.g., zolpidem)
    40%

    Effects Erowid

    Aggregated from 9 Erowid experience reports

    Positive Effects 5

    Anxiety Suppression 77.8% 70%
    Sedation 66.7% 70%
    Euphoria 55.6% 70%
    Stimulation 55.6% 70%
    Color Enhancement 33.3% 70%

    Adverse Effects 2

    Muscle Tension 33.3% 70%
    Increased Heart Rate 33.3% 70%

    Combinations TripSit

    Trip Reports Effect Index

    Pyrazolam Dilemma
    Pyrazolam's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki 📖 TripSit 📖 The Drug Users Bible