Pyrovalerone
Aliases: O-2371, Centroton, Thymergix, 4-methyl-ฮฒ-keto-prolintane
Summary
Pyrovalerone was originally prescribed for chronic fatigue and obesity in the 1960s at daily doses of 60 mg (20 mg three times daily), but patients frequently developed tolerance and compulsive redosing, leading to discontinuation of its clinical use. Modern reports describe it as a stimulant with a profile between methylphenidate and MDPV, with strong drive to redose every 2-3 hours. Its pharmacology shows high affinity inhibition of dopamine and norepinephrine transporters, with negligible serotonin activity.
Dose Information
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral | 10-30 min | 30-60 min | 30 min | 1-3 hrs |
| Insufflated | 5-10 min | 15-30 min | 30 min | 1-3 hrs |
| Rectal | 10-20 min | 20-40 min | 30 min | 1-3 hrs |
| Intravenous | 2 min | 2-5 min | 30 min | 1-3 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong anxiety/jitters with moderate euphoria, mild stimulation, low focus
Tolerance
Tolerance Decay
Model is an anecdotal approximation based on pyrrolidinophenone user reports: rapid escalation during binges with partial recovery over several days; crossโtolerance within the class is expected given shared DAT/NET inhibition. Treat this as a planning aid for spacing sessions, not a guarantee. Data quality: anecdotal/communityโderived.
Cross-Tolerances
Effects
- Stimulation
- Increased Energy
- Teeth grinding
- Increased heart rate
- Pupil Dilation
- Increased Heart Rate
- Jaw Tension
- Restlessness
- Teeth Grinding
- Difficulty Sleeping
- Motivation enhancement
- Euphoria
- Enhanced Sociability
- Motivation Enhancement
- Anxiety
- Compulsive redosing
- Irritability
- Depression
- Increased focus
- Talkativeness
- Increased libido
- Tactile enhancement
- Increased music appreciation
- Appetite suppression
- Light sensitivity
- Appetite Suppression
- Disinhibition
- Dehydration
- Vibrating vision
- Increase sexuality