Serdexmethylphenidate
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
- partial dose data
- duration data present
- dose data not in PW/TripSit (unverifiable)
- 1 source
- partial dose data
- duration data present
- dose data not in PW/TripSit (unverifiable)
Aliases: Sdx, Kp415, Azstarys
Summary
Serdexmethylphenidate is a prodrug of dexmethylphenidate designed to provide extended therapeutic effects with reduced abuse potential through delayed onset. FDA-approved in 2021 as part of Azstarys for ADHD treatment in patients 6 years and older. The substance is metabolized in the lower gastrointestinal tract to release dexmethylphenidate gradually.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 26.1 mg (with 5.2 mg dexmethylphenidate) | - | - | - |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 1-2 hrs | 2-3 hrs | 4-8 hrs | 3-5 hrs | 10-18 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong anxiety/jitters with moderate euphoria and focus, mild stimulation
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Serdexmethylphenidate there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Serdexmethylphenidate Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold Not established · light 26.1 (with 5.2 dexmethylphenidate) Oral duration: onset 1-2h · come-up 2-3h · peak 4-8h · offset 3-5h · total 10-18h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Model extrapolated from stimulant-class patterns (methylphenidate/amphetamines) and clinical experience; high individual variability. Drug holidays may partially reverse tolerance but should only be done with medical guidance. Data quality is limited for SDX specifically.
Cross-Tolerances
Effects
- Stimulation
- Physical Euphoria
- Creativity Enhancement
- Increased heart rate
- Nausea
- Increased blood pressure
- Increased perspiration
- Vasoconstriction
- Sedation
- Difficulty urinating
- Focus enhancement
- Motivation enhancement
- Wakefulness
- Cognitive euphoria
- Analysis enhancement
- Anxiety
- Irritability
- Time distortion
- Tactile Enhancement
- Increased Music Appreciation
- Increased libido
- Pattern Recognition Enhancement
- Synaesthesia
- Appetite suppression
- Light sensitivity
- Auditory hallucination
- Dulled perception
- Auditory distortion
Pill Identifiers
Helpful Links
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