Serdexmethylphenidate - Substance Search

Summary TheDrug.Wiki

Serdexmethylphenidate is a prodrug of dexmethylphenidate designed to provide extended therapeutic effects with reduced abuse potential through delayed onset. FDA-approved in 2021 as part of Azstarys for ADHD treatment in patients 6 years and older. The substance is metabolized in the lower gastrointestinal tract to release dexmethylphenidate gradually.

Dose Information TheDrug.Wiki

ROA	Light	Common	Strong	Heavy
Oral	26.1mg(with5.2mgdexmethylphenidate)	-	-	-

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki

ROA	Onset	Comeup	Peak	Offset
Oral	1-2 hrs	2-3 hrs	4-8 hrs	3-5 hrs

Effect Profile

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Stimulant 6.4

Strong 6/10

Strong euphoria and anxiety/jitters with moderate focus, mild stimulation

Stimulation / Energy ×3

5

stimulation wakefulness

Euphoria / Mood Lift ×2

10

physical euphoria cognitive euphoria motivation enhancement

Focus / Productivity ×2

7

focus enhancement analysis enhancement motivation enhancement

⚠ Anxiety / Jitters ×1

8

anxiety increased heart rate vasoconstriction

Based on reports from:

Erowid Experience Reports PsychonautWiki Serdexmethylphenidate

Tolerance

Build-up develops over days to weeks of regular use

Reset 3–7 days for acute tolerance; longer for full reset

Tolerance Decay

Full tolerance 14d Half tolerance 7d Baseline ~28d

Model extrapolated from stimulant-class patterns (methylphenidate/amphetamines) and clinical experience; high individual variability. Drug holidays may partially reverse tolerance but should only be done with medical guidance. Data quality is limited for SDX specifically.