Serdexmethylphenidate
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
- partial dose data
- duration data present
- dose data not in PW/TripSit (unverifiable)
- 1 source
- partial dose data
- duration data present
- dose data not in PW/TripSit (unverifiable)
Aliases: Sdx, Kp415, Azstarys
Summary
Serdexmethylphenidate is a prodrug of dexmethylphenidate designed to provide extended therapeutic effects with reduced abuse potential through delayed onset. FDA-approved in 2021 as part of Azstarys for ADHD treatment in patients 6 years and older. The substance is metabolized in the lower gastrointestinal tract to release dexmethylphenidate gradually.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 26.1mg(with5.2mgdexmethylphenidate) | - | - | - |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral | 1-2 hrs | 2-3 hrs | 4-8 hrs | 3-5 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria and anxiety/jitters with moderate focus, mild stimulation
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Model extrapolated from stimulant-class patterns (methylphenidate/amphetamines) and clinical experience; high individual variability. Drug holidays may partially reverse tolerance but should only be done with medical guidance. Data quality is limited for SDX specifically.
Cross-Tolerances
Effects
- Stimulation
- Physical Euphoria
- Creativity Enhancement
- Increased heart rate
- Nausea
- Increased blood pressure
- Increased perspiration
- Vasoconstriction
- Sedation
- Difficulty urinating
- Focus enhancement
- Motivation enhancement
- Wakefulness
- Cognitive euphoria
- Analysis enhancement
- Cognitive Euphoria
- Anxiety
- Irritability
- Time distortion
- Time Distortion
- Tactile Enhancement
- Increased Music Appreciation
- Increased libido
- Pattern Recognition Enhancement
- Synaesthesia
- Appetite suppression
- Light sensitivity
- Auditory hallucination
- Dulled perception
- Auditory distortion
Pill Identifiers
Helpful Links
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