Sibutramine
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- PubChem toxicity data
- dose data not in PW/TripSit (unverifiable)
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- PubChem toxicity data
- dose data not in PW/TripSit (unverifiable)
Aliases: Meridia, Siredia, Reductil, Sibutrex
Summary
Sibutramine was withdrawn from most markets in 2010 due to increased risk of cardiovascular events (heart attack and stroke), particularly in patients with pre-existing cardiovascular disease. It is a centrally acting appetite suppressant that acts as a prodrug, metabolized to more potent active metabolites (M1 and M2) with longer half-lives. Unlike amphetamines, it does not cause monoamine release and does not produce euphoria.
Dose Information
Dose basis. Doses are based on clinical use in obesity and once-daily administration; not recommended for recreational use. Redosing the same day raises cardiovascular risk due to long-acting active metabolites. Information primarily from clinical and pharmacology sources; not user-report derived. (Dose figures and this note are from Drugs.Wiki.)
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-10mg | 10-15mg | 15-20mg | 20mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 1-2 hrs | 1-2 hrs | 3-6 hrs | 12-24 hrs | 17-34 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Moderate stimulation and anxiety/jitters with low euphoria
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Sibutramine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Sibutramine Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 5 · light 5-10 · common 10-15 · strong 15-20 · heavy 20+ Oral duration: onset 1-2h · come-up 1-2h · peak 3-6h · offset 12-24h · total 17-34h · after-effects 24h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 12.5 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Robust human tolerance kinetics are not well characterized. Anecdotally, some loss of appetite-suppressing effect occurs over weeks with daily use and partially reverses over several weeks of abstinence. Data quality is low; model provided for harm-reduction planning rather than precise prediction.
Cross-Tolerances
Effects
- Stimulation
- Increased energy
- Pain Relief
- Muscle Relaxation
- Increased heart rate
- Increased blood pressure
- Dry mouth
- Insomnia
- Nausea
- Headache
- Alertness enhancement
- Reduced anxiety
- Anxiety suppression
- Cognitive euphoria
- Dream potentiation
- Anxiety
- Dizziness
- Constipation
- Drowsiness
- Talkativeness
- Increased music appreciation
- Appetite suppression
- Light sensitivity
- Double vision
- Disinhibition
- Acuity suppression
- Visual acuity suppression
- Dulled perception
- Internal hallucination
- Perception of bodily heaviness
Pill Identifiers
Helpful Links
Report an issue or suggest an edit
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