Summary
Sibutramine was withdrawn from most markets in 2010 due to increased risk of cardiovascular events (heart attack and stroke), particularly in patients with pre-existing cardiovascular disease. It is a centrally acting appetite suppressant that acts as a prodrug, metabolized to more potent active metabolites (M1 and M2) with longer half-lives. Unlike amphetamines, it does not cause monoamine release and does not produce euphoria. Contraindicated in patients with history of cardiovascular disease, uncontrolled hypertension, eating disorders, severe depression, mania, or narrow-angle glaucoma. Regular blood pressure monitoring is essential during use.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 1-2 hrs | 1-2 hrs | 3-6 hrs | 12-24 hrs | 24 hrs |
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute tolerance; longer for full reset
Effects
Positive
- Stimulation
- Increased energy
- Pain Relief
- Muscle Relaxation
Negative
- Increased heart rate
- Increased blood pressure
- Dry mouth
- Insomnia
- Nausea
- Headache
Positive
- Alertness enhancement
- Reduced anxiety
- Anxiety suppression
- Cognitive euphoria
- Dream potentiation
Negative
- Anxiety
- Dizziness
- Constipation
- Drowsiness
- Talkativeness
Positive
- Increased music appreciation
Negative
- Appetite suppression
- Light sensitivity
- Double vision
- Disinhibition
- Acuity suppression
- Visual acuity suppression
- Dulled perception
- Internal hallucination
- Perception of bodily heaviness