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    Disclaimer
    πŸ§ͺ This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    SR-17018

    Aliases: 5,6-dichloro desmethylchlorphine

    Depressant Research-chemical Opioid

    Summary TheDrug.Wiki

    Sold solely as a research chemical with no quality control or clinical data in humans. SR-17018 is not orally bioavailable when dissolved in water due to poor solubility; must be taken as powder or with appropriate excipients. Primarily reported for opioid tapering due to craving suppression and tolerance reduction properties, not recreation.

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Comeup Peak Offset After Effects
    Oral 15-45 min 30-60 min 1-3 hrs 4-6 hrs 2-4 hrs
    Sublingual 10-30 min 20-45 min 1-3 hrs 4-6 hrs 2-4 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 4.7
    Moderate+ 5/10

    Moderate euphoria and itching/nausea with mild pain relief, low sedation

    Euphoria / Warmth ×3
    6
    physical euphoria cognitive euphoria
    Analgesia ×2
    4
    pain relief
    Sedation / Relaxation ×1
    3
    sedation
    ⚠ Itching / Nausea ×1
    6
    nausea constipation
    Based on reports from:
    Erowid Experience Reports PsychonautWiki SR-17018
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks β€” tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 7d Half tolerance 3d Baseline ~14d

    Model reflects preclinical evidence for relatively slower tolerance build than morphine in some assays and community reports of tolerance reduction during SR‑17018 use; human kinetics unknown. Values are heuristic for harm‑reduction planning, not physiological truths.

    Cross-Tolerances

    Other μ‑opioid agonists
    70%

    Effects TheDrug.Wiki

    Positive
    • Pain relief
    • Physical euphoria
    • Stimulation
    Negative
    • Nausea
    • Respiratory depression
    • Pupil dilation
    • Increased heart rate
    • Teeth grinding
    Neutral
    • Sedation
    • Itchiness
    Positive
    • Cognitive euphoria
    • Craving suppression
    • Anxiety suppression
    • Wakefulness
    • Focus enhancement
    • Motivation enhancement
    Negative
    • Constipation
    • Dizziness
    • Anxiety
    • Cognitive fatigue
    Positive
    • Tactile enhancement
    • Color enhancement
    • Increased music appreciation
    Negative
    • Appetite suppression
    • Light sensitivity
    • Disinhibition
    Neutral
    • Dulled perception
    • Increased sexuality
    • Visual and auditory hallucinations
    • Drifting

    Combinations TripSit

    SR-17018's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    πŸ“˜ Experience Reports πŸ“– TheDrug.Wiki πŸ“– PsychonautWiki