Summary
Sold solely as a research chemical with no quality control or clinical data in humans. SR-17018 is not orally bioavailable when dissolved in water due to poor solubility; must be taken as powder or with appropriate excipients. Primarily reported for opioid tapering due to craving suppression and tolerance reduction properties, not recreation. CRITICAL: Reduces opioid tolerance rapidly; returning to previous opioid doses after using SR-17018 risks fatal overdose.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 15-45 min | 30-60 min | 1-3 hrs | 4-6 hrs | 2-4 hrs |
| Sublingual | 10-30 min | 20-45 min | 1-3 hrs | 4-6 hrs | 2-4 hrs |
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Effects
Positive
- Pain relief
- Physical euphoria
- Stimulation
Negative
- Nausea
- Respiratory depression
- Pupil dilation
- Increased heart rate
- Teeth grinding
- Sedation
- Itchiness
Positive
- Cognitive euphoria
- Craving suppression
- Anxiety suppression
- Wakefulness
- Focus enhancement
- Motivation enhancement
Negative
- Constipation
- Dizziness
- Anxiety
- Cognitive fatigue
Positive
- Tactile enhancement
- Color enhancement
- Increased music appreciation
Negative
- Appetite suppression
- Light sensitivity
- Disinhibition
- Dulled perception
- Increased sexuality
- Visual and auditory hallucinations
- Drifting