Summary
Theacrine is a structural analog of caffeine with about two-thirds the potency for stimulation but stronger effects on focus. It has a biphasic dose-response: low doses may be sedating while higher doses are stimulating. Unlike caffeine, theacrine does not appear to significantly affect blood pressure.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 50-100mg | 100-150mg | 150-300mg | 300mg+ |
| Insufflated | - | 25-100mg | - | - |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Total |
|---|---|---|
| Oral | 30-60 min | 30-60 min |
| Insufflated | 5-30 min | 5-30 min |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Stimulant
6.4
Strong
6/10
Strong focus and anxiety/jitters with moderate euphoria, mild stimulation
Stimulation / Energy
×3
5
stimulation
wakefulness
Euphoria / Mood Lift
×2
7
physical euphoria
cognitive euphoria
motivation enhancement
Focus / Productivity
×2
10
focus enhancement
analysis enhancement
memory enhancement
motivation enhancement
thought acceleration
Anxiety / Jitters
×1
8
anxiety
bruxism
increased heart rate
Based on reports from:
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute tolerance; longer for full reset
Tolerance Decay
Full tolerance
1d
Half tolerance
10d
Baseline
~18d
Effects
Positive
- Stimulation
- Pain Relief
- Bronchodilation
- Physical euphoria
Negative
- Nausea
- Bruxism
- Increased heart rate
- Increased blood pressure
- Increased perspiration
- Frequent urination
Positive
- Focus Enhancement
- Analysis Enhancement
- Motivation Enhancement
- Memory Enhancement
- Wakefulness
- Cognitive Euphoria
Negative
- Anxiety
- Compulsive Redosing
- Irritability
- Thought Acceleration
Positive
- Increased Music Appreciation
- Increased Libido
- Increased libido
- Tactile enhancement
- Increased music appreciation
Negative
- Appetite Suppression
- Light sensitivity
- Appetite suppression
- Dehydration
- Disinhibition
Theacrine's nerd page
Pharmacology, chemical data, effect profiles, and more
→