Summary
Theacrine is a structural analog of caffeine with about two-thirds the potency for stimulation but stronger effects on focus. It has a biphasic dose-response: low doses may be sedating while higher doses are stimulating. Unlike caffeine, theacrine does not appear to significantly affect blood pressure. Effects take longer to manifest (approximately 2 hours to peak plasma concentration) compared to caffeine but are more persistent due to its longer half-life. At higher doses, forced stimulation may lead to jaw clenching, involuntary shakes, and loss of motor control.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 50-100mg | 100-150mg | 150-300mg | 300mg+ |
| Insufflated | - | 25-100mg | - | - |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Total |
|---|---|---|
| Oral | 30-60 min | 120-0 min |
| Insufflated | 5-30 min | 120-0 min |
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute tolerance; longer for full reset
Effects
Positive
- Stimulation
- Pain Relief
- Bronchodilation
- Physical euphoria
Negative
- Nausea
- Bruxism
- Increased heart rate
- Increased blood pressure
- Increased perspiration
- Frequent urination
Positive
- Focus Enhancement
- Analysis Enhancement
- Motivation Enhancement
- Memory Enhancement
- Wakefulness
- Cognitive Euphoria
Negative
- Anxiety
- Compulsive Redosing
- Irritability
- Thought Acceleration
Positive
- Increased Music Appreciation
- Increased Libido
- Increased libido
- Tactile enhancement
- Increased music appreciation
Negative
- Appetite Suppression
- Light sensitivity
- Appetite suppression
- Dehydration
- Disinhibition