Thiopental
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 2 corroborating sources
- duration data present
- PubChem toxicity data
- 2 corroborating sources
- duration data present
- PubChem toxicity data
Aliases: Pentothal, Thiopentone, Penthiobarbital, Sodium pentothal, Sodium thiopental
Summary
Thiopental is an ultra-short-acting barbiturate used primarily for anesthesia induction, rapid sedation, emergency seizure control, and reducing intracranial pressure. It must be administered intravenously by trained medical professionals. The drug's brief duration of action results from rapid redistribution to fat and muscle tissue rather than metabolism.
Dose Information
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Intravenous | 1 min | 1 min | 1-2 min | 5-15 min |
Tolerance
Tolerance Decay
Clinically, acute tolerance to hypnotic effects can develop rapidly with repeated doses during a case; chronic tolerance and dependence are well documented with barbiturates as a class. Data specific to thiopental tolerance kinetics in humans are limited; estimates here reflect class effects and expert inference.
Cross-Tolerances
Effects
- Muscle relaxation
- Physical Euphoria
- Analgesia
- Loss of consciousness
- Respiratory depression
- Nausea
- Sedation
- Decreased intracranial pressure
- Reduction of external stimuli
- Buzzing sensation in nerve
- Anxiety suppression
- Reduced anxiety
- Cognitive Euphoria
- Laughter Fits
- Amnesia
- Motor control loss
- Cognitive impairment
- Motor Control Loss
- Ego Death
- Dissociation
- Visual Geometry
- Disinhibition
- Tactile Suppression
- Acuity suppression
- Auditory suppression
- Dulled perception
- Auditory Distortion
- Sound distortion
- Minor to strong hallucinations
- Changes in felt bodily form
Helpful Links
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