1-(2,5-Dimethoxybenzyl) piperazine
Aliases: 2c-benzylpiperazine, 2,5-dimethoxybenzyl
Categories
Summary
Very little peer-reviewed human data exist. Limited forensic reports indicate occasional appearance in illicit 'party pill' blends between 2013-2019. Animal receptor-binding screens show micromolar affinity for 5-HT2A/2C and moderate inhibition of serotonin uptake, suggesting a hybrid psychedelic-stimulant profile comparable to 4-bromo-2,5-dimethoxy-BZP (2C-B-BZP) but with lower potency. Users report a slow come-up, mild closed-eye visuals, warmth/euphoria, tachycardia, jaw tension and long-lasting stimulation. Nausea, vasoconstriction and headaches are common at >80 mg.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 0.75-2 hrs | 30-90 min | 3-6 hrs | 1.5-3 hrs | 12-24 hrs |
Tolerance
Build-up
develops rapidly after a single use
Reset
7–14 days for baseline
Effects
Positive
- Stimulation
Negative
- Teeth grinding
- Pupil dilation
- Nausea
- Vasoconstriction
- Bruxism
- Tachycardia
- Insomnia
- Headache
- Elevated blood pressure
Positive
- Euphoria
- Increased sociability
- Wakefulness
- Alertness enhancement
- Enhanced music appreciation
- Empathy Enhancement
- Focus enhancement
Negative
- Anxiety
- Dizziness
- Talkativeness
Positive
- Visual enhancement
- Pattern recognition enhancement
- Colour enhancement
- Tactile enhancement
- Bodily control enhancement
- Color Enhancement
- Tracers
Negative
- Appetite suppression
- Light sensitivity
- Closed-Eye Visuals