Home
    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    1-(2,5-Dimethoxybenzyl) piperazine

    Aliases: 2c-benzylpiperazine, 2,5-dimethoxybenzyl

    Psychedelic Stimulant Research-chemical

    Summary TheDrug.Wiki

    Very little peer-reviewed human data exist. Limited forensic reports indicate occasional appearance in illicit 'party pill' blends between 2013-2019. Animal receptor-binding screens show micromolar affinity for 5-HT2A/2C and moderate inhibition of serotonin uptake, suggesting a hybrid psychedelic-stimulant profile comparable to 4-bromo-2,5-dimethoxy-BZP (2C-B-BZP) but with lower potency.

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Comeup Peak Offset After Effects
    Oral 0.75-2 hrs 30-90 min 3-6 hrs 1.5-3 hrs 12-24 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 4.0
    Moderate 4/10

    Strong visuals and body load with mild auditory effects

    Visual Intensity ×3
    9
    colour enhancement tracers visual enhancement pattern recognition enhancement
    Headspace Depth ×3
    0
    Auditory Effects ×1
    4
    enhanced music appreciation
    ⚠ Body Load / Somatic Effects ×1
    9
    nausea vasoconstriction teeth grinding bruxism tachycardia
    Stimulant 3.8
    Moderate 4/10

    Strong anxiety/jitters with moderate stimulation, low euphoria and focus

    Stimulation / Energy ×3
    6
    stimulation wakefulness alertness enhancement
    Euphoria / Mood Lift ×2
    3
    euphoria
    Focus / Productivity ×2
    3
    focus enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety teeth grinding bruxism tachycardia vasoconstriction
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 1-(2,5-Dimethoxybenzyl) piperazine
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    Negative
    • Teeth grinding
    • Pupil dilation
    • Nausea
    • Vasoconstriction
    • Bruxism
    • Tachycardia
    • Insomnia
    • Headache
    Neutral
    • Elevated blood pressure
    Positive
    • Euphoria
    • Increased sociability
    • Wakefulness
    • Alertness enhancement
    • Enhanced music appreciation
    • Empathy Enhancement
    • Focus enhancement
    Negative
    • Anxiety
    • Dizziness
    Neutral
    • Talkativeness
    Positive
    • Visual enhancement
    • Pattern recognition enhancement
    • Colour enhancement
    • Tactile enhancement
    • Bodily control enhancement
    • Color Enhancement
    • Tracers
    Negative
    • Appetite suppression
    • Light sensitivity
    Neutral
    • Closed-Eye Visuals

    Combinations TripSit

    1-(2,5-Dimethoxybenzyl) piperazine's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki