1-(2,5-Dimethoxybenzyl) piperazine
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Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: 2c-benzylpiperazine, 2,5-dimethoxybenzyl
Summary
Very little peer-reviewed human data exist. Limited forensic reports indicate occasional appearance in illicit 'party pill' blends between 2013-2019. Animal receptor-binding screens show micromolar affinity for 5-HT2A/2C and moderate inhibition of serotonin uptake, suggesting a hybrid psychedelic-stimulant profile comparable to 4-bromo-2,5-dimethoxy-BZP (2C-B-BZP) but with lower potency.
Dose Information
Dose basis. Ranges are extrapolated from limited user reports and by-analogy to other benzyl/phenylpiperazines; treat as highly uncertain. Start with an allergy test (1–2 mg), then a low test dose only after no adverse reaction. Many piperazines are supplied as hydrochloride salts; milligram potency may differ vs freebase. Avoid redosing for at least 3 hours due to delayed peak and risk of cumulative toxicity. (Dose figures and this note are from Drugs.Wiki.)
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 20-40mg | 40-80mg | 80-120mg | 120mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 0.75-2 hrs | 30-90 min | 3-6 hrs | 1.5-3 hrs | 5.75-12.5 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong visuals and body load with mild auditory effects
Strong anxiety/jitters with moderate stimulation, low euphoria and focus
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track 1-(2,5-Dimethoxybenzyl) piperazine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
1-(2,5-Dimethoxybenzyl) piperazine Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 10 · light 20-40 · common 40-80 · strong 80-120 · heavy 120+ Oral duration: onset 0.75-2h · come-up 0.5-1.5h · peak 3-6h · offset 1.5-3h · total 5.75-12.5h · after-effects 12-24h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 60 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
- Stimulation
- Teeth grinding
- Pupil dilation
- Nausea
- Vasoconstriction
- Bruxism
- Tachycardia
- Insomnia
- Headache
- Elevated blood pressure
- Euphoria
- Increased sociability
- Wakefulness
- Alertness enhancement
- Enhanced music appreciation
- Empathy Enhancement
- Focus enhancement
- Anxiety
- Dizziness
- Talkativeness
- Visual enhancement
- Pattern recognition enhancement
- Colour enhancement
- Tactile enhancement
- Bodily control enhancement
- Color Enhancement
- Tracers
- Appetite suppression
- Light sensitivity
- Closed-Eye Visuals
Combinations
Cross-Check 1-(2,5-Dimethoxybenzyl) piperazine with another substanceHelpful Links
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