1,4-DMAA
Aliases: 1,4-dimethylamylamine, 5-methylhexan-2-amine
Categories
Summary
1,4-DMAA is a positional isomer of 1,3-DMAA with limited human safety data. Anecdotal reports suggest it produces smoother stimulation with enhanced mood elevation compared to 1,3-DMAA. It raises heart rate and blood pressure, causes vasoconstriction, and can precipitate serious cardiovascular events including tachyarrhythmias and intracranial hemorrhage at high doses or in susceptible individuals. Found in dietary supplements at doses ranging from 21-94 mg per serving. The FDA considers products containing 1,4-DMAA to be illegal dietary supplements.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 15-45 min | 30-60 min | 45 min | 2-3 hrs | 2-6 hrs |
| Insufflated | 5-15 min | 15-30 min | 45 min | 2-3 hrs | 2-6 hrs |
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute tolerance; longer for full reset
Effects
Positive
- Stimulation
Negative
- Increased heart rate
- Increased perspiration
- Vasoconstriction
- Teeth grinding
- Restlessness
- Increased blood pressure
- Tachycardia
- Temperature regulation suppression
- Difficulty urinating
Positive
- Focus enhancement
- Motivation enhancement
- Euphoria
- Increased sociability
- Enhanced focus
- Cognitive enhancement
Negative
- Anxiety
- Irritability
- Cognitive fatigue
- Time distortion
Positive
- Increased libido
- Color enhancement
- Increased music appreciation
- Tactile enhancement
Negative
- Appetite suppression
- Light sensitivity
- Dehydration
- Disinhibition
- Dulled perception
- Drifting