1,4-DMAA
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 2 corroborating sources
- duration data present
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- duration data present
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: 1,4-dimethylamylamine, 5-methylhexan-2-amine
Summary
1,4-DMAA is a positional isomer of 1,3-DMAA with limited human safety data. Anecdotal reports suggest it produces smoother stimulation with enhanced mood elevation compared to 1,3-DMAA. It raises heart rate and blood pressure, causes vasoconstriction, and can precipitate serious cardiovascular events including tachyarrhythmias and intracranial hemorrhage at high doses or in susceptible individuals.
Dose Information
| ROA | Threshold |
|---|---|
| Oral | 5-10 |
| Insufflated | 5 |
Only a threshold dose is documented for this substance — the smallest amount with a noticeable effect. There is no published light/common/strong ladder to show above it.
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 15-45 min | 30-60 min | 45 min | 2-3 hrs | 3.5-5.5 hrs |
| Insufflated | 5-15 min | 15-30 min | 45 min | 2-3 hrs | 3.08-4.5 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong focus and anxiety/jitters with mild euphoria, low stimulation
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track 1,4-DMAA there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
1,4-DMAA Source: SubstanceSearch (substancesearch.com) Oral dose: threshold 5-10 Insufflated dose: threshold 5 Oral duration: onset 15-45m · come-up 0.5-1h · peak 45m · offset 2-3h · total 3.5-5.5h · after-effects 2-6h Insufflated duration: onset 5-15m · come-up 15-30m · peak 45m · offset 2-3h · total 3.08-4.5h · after-effects 2-6h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
- Stimulation
- Increased heart rate
- Increased perspiration
- Vasoconstriction
- Teeth grinding
- Restlessness
- Increased blood pressure
- Tachycardia
- Temperature regulation suppression
- Difficulty urinating
- Focus enhancement
- Motivation enhancement
- Euphoria
- Increased sociability
- Enhanced focus
- Cognitive enhancement
- Anxiety
- Irritability
- Cognitive fatigue
- Time distortion
- Increased libido
- Color enhancement
- Increased music appreciation
- Tactile enhancement
- Appetite suppression
- Light sensitivity
- Dehydration
- Disinhibition
- Dulled perception
- Drifting
Helpful Links
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