1S-LSD - Substance Search

Summary dose.wiki

1S-LSD (1-(3-trimethylsilyl-propionyl)-LSD) is a psychedelic lysergamide, a silicon-containing N1-acyl analogue of LSD designed to circumvent Germany's NpSG following the 1D-LSD ban in June 2024. It acts as a prodrug: analytical studies confirm it hydrolyzes in vitro and in vivo to LSD-25. User reports and reagent-testing services indicate the blotters do not trigger Ehrlich or DMAB reagents, necessitating laboratory confirmation.

Dose Information dose.wiki Drugs.Wiki

Dose basis. Dose guidance primarily extrapolated from community reports and prior N1‑acyl lysergamides. 1S‑LSD is generally reported to have a slower onset than LSD‑25; allow at least 2–3 hours before considering any redose to avoid accidental overconsumption. Potency per microgram is expected to be lower than LSD due to added N1‑substituent mass; user reports commonly assume ~70% potency by mass conversion, but batch variability exists. Evidence basis: Reddit community reports on delayed onset and approximate potency conversion; formal lab PK data for 1S‑LSD are limited; LSD baselines from TripSit/Erowid. Some users keep blotters under the tongue for 15–30 minutes. For 1‑acyl lysergamides, sublingual vs swallowed onset differences are inconsistent across reports; do not assume faster onset. Wait ≥2 hours before any redose. Same nominal ranges as oral, but expect variability. Evidence basis: community threads describing variable onset with 1S‑LSD; LSD general durations from TripSit/Erowid. (Dose figures and this note are from Drugs.Wiki.)

ROA	Light	Common	Strong	Heavy
Oral	15-50µg	50-170µg	170-300µg	300µg+
Sublingual	15-50µg	50-170µg	170-300µg	300µg+

Light Common Strong Heavy

Onset, Duration & After-effects dose.wiki Drugs.Wiki

ROA	Onset	Peak	Offset	After Effects	Total
Oral	0.75-3 hrs	3-5 hrs	2-4 hrs	6-24 hrs	9-12 hrs
Sublingual	0.75-3 hrs	3-5 hrs	2-4 hrs	6-24 hrs	9-12 hrs

Effect Profile

4 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Psychedelic 5.0

Moderate+ 5/10

Moderate visuals, headspace, and body load

Visual Intensity ×3

6

color enhancement tracers visual enhancement visual distortions

Headspace Depth ×3

6

conceptual thinking introspection thought loops time distortion

Auditory Effects ×1

0

⚠ Body Load / Somatic Effects ×1

6

vasoconstriction nausea increased heart rate

Based on reports from:

Erowid Experience Reports

Add to PsychonautWiki Journal

The PsychonautWiki Journal logging app doesn't include every substance. To track 1S-LSD there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

⬇ Download import file Import this file as custom substances and you get "1S-LSD (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.

Name

1S-LSD

Unit

µg

Description

1S-LSD
Source: SubstanceSearch (substancesearch.com)

Oral dose (µg): threshold 15 · light 15-50 · common 50-170 · strong 170-300 · heavy 300+
Sublingual dose (µg): threshold 15 · light 15-50 · common 50-170 · strong 170-300 · heavy 300+

Oral duration: onset 0.75-3h · peak 3-5h · offset 2-4h · total 9-12h · after-effects 6-24h
Sublingual duration: onset 0.75-3h · peak 3-5h · offset 2-4h · total 9-12h · after-effects 6-24h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 110 µg (Oral).

The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

Tolerance

Build-up develops rapidly after a single use (lysergamide)

Reset 7–14 days for baseline

Tolerance Decay

Half tolerance 7d Baseline ~14d

Rapid tachyphylaxis after one strong session; most effects markedly reduced next day. Approximate return to baseline sensitivity after 7–14 days. Data quality mixed: clinical for LSD itself; inference for 1S‑LSD.

Cross-Tolerances

LSD‑25

90%

other N1‑acyl lysergamides (1P‑LSD, 1B‑LSD, etc.)

90%

psilocin / psilocybin

70%

Effects Erowid

Aggregated from 4 Erowid experience reports

Positive Effects 7

Color Enhancement 100.0% 70%

Music Enhancement 100.0% 70%

Empathy 75.0% 70%

Focus Enhancement 75.0% 70%

Tactile Enhancement 75.0% 70%

Euphoria 75.0% 70%

Stimulation 75.0% 70%

Adverse Effects 2

Anxiety 75.0% 70%

Confusion 75.0% 70%

Combinations

Cross-Check 1S-LSD with another substance

Community Trip Reports

Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

Erowid 3 reports 2 neutral 1 cautionary visit

Lost in the Forest Under Fractal Skies neutral exp #119203

I have tried 1S-LSD a couple of times and I have done 125 mcg previously alone but this was my most intense trip so far. Neither the set nor the setting was very optimal, and I could feel it at the beginning of the trip. Previous night I spent doing some ketamine and smoking weed at home with a friend.

A Two-Day Long Attack on Sanity cautionary exp #118371

Note: Two days before this trip, I stopped taking agomelatine, a medicine I had been using regularly for better sleep. I had been gradually increasing my LSD doses, with the effects intensifying as I went higher. However, I had been on agomelatine for most of these trips.

Glowing Alive neutral exp #118904

First Experience / Glowing Alive Having taken 1S-LSD 5 days prior in a 20mcg dose, I felt little to nothing. Maybe a little euphoria but barely noticable. 5 days after my first encounter I tried 80mcg and was ready for the effects.

1S-LSD's nerd page Pharmacology, chemical data, effect profiles, and more

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Helpful Links

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1S-LSD Encyclopedic Encyclopedic Typical encyclopedia coverage. Cross-reference for important decisions. 2 corroborating sources 2 ROAs with full dose ladders duration data present 19 combo interactions documented classified Research-chemical dose data not in PW/TripSit (unverifiable)