I have tried 1S-LSD a couple of times and I have done 125 mcg previously alone but this was my most intense trip so far. Neither the set nor the setting was very optimal, and I could feel it at the beginning of the trip. Previous night I spent doing some ketamine and smoking weed at home with a friend.
1S-LSD
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Summary
1S-LSD (1-(3-trimethylsilyl-propionyl)-LSD) is a psychedelic lysergamide, a silicon-containing N1-acyl analogue of LSD designed to circumvent Germany's NpSG following the 1D-LSD ban in June 2024. It acts as a prodrug: analytical studies confirm it hydrolyzes in vitro and in vivo to LSD-25. User reports and reagent-testing services indicate the blotters do not trigger Ehrlich or DMAB reagents, necessitating laboratory confirmation.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 15-50µg | 50-170µg | 170-300µg | 300µg+ |
| Sublingual | 15-50µg | 50-170µg | 170-300µg | 300µg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 0.75-3 hrs | 3-5 hrs | 2-4 hrs | 9-12 hrs |
| Sublingual | 0.75-3 hrs | 3-5 hrs | 2-4 hrs | 9-12 hrs |
Effect Profile
4 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
6.5
Strong
6/10
Strong visuals and headspace with moderate body load
Visual Intensity
×3
8
color enhancement
tracers
visual enhancement
visual distortions
Headspace Depth
×3
8
conceptual thinking
introspection
thought loops
time distortion
Auditory Effects
×1
0
Body Load / Somatic Effects
×1
6
vasoconstriction
nausea
increased heart rate
Based on reports from:
Tolerance
Build-up
develops rapidly after a single use (lysergamide)
Reset
7–14 days for baseline
Tolerance Decay
Half tolerance
7d
Baseline
~14d
Rapid tachyphylaxis after one strong session; most effects markedly reduced next day. Approximate return to baseline sensitivity after 7–14 days. Data quality mixed: clinical for LSD itself; inference for 1S‑LSD.
Cross-Tolerances
Effects
Aggregated from 4 Erowid experience reports
Positive Effects 7
Color Enhancement
100.0%
70%
Music Enhancement
100.0%
70%
Empathy
75.0%
70%
Focus Enhancement
75.0%
70%
Tactile Enhancement
75.0%
70%
Euphoria
75.0%
70%
Stimulation
75.0%
70%
Adverse Effects 2
Anxiety
75.0%
70%
Confusion
75.0%
70%
Combinations
Cross-Check 1S-LSD with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 3 reports 3 neutral visit
Note: Two days before this trip, I stopped taking agomelatine, a medicine I had been using regularly for better sleep. I had been gradually increasing my LSD doses, with the effects intensifying as I went higher. However, I had been on agomelatine for most of these trips.
First Experience / Glowing Alive Having taken 1S-LSD 5 days prior in a 20mcg dose, I felt little to nothing. Maybe a little euphoria but barely noticable. 5 days after my first encounter I tried 80mcg and was ready for the effects.
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