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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    1S-LSD

    Psychedelic Research-chemical

    Summary TheDrug.Wiki

    1S-LSD is 1-(3-trimethylsilyl-propionyl)-LSD, a silicon-containing N1-acyl analogue designed to circumvent Germany's NpSG following the 1D-LSD ban in June 2024. Analytical studies confirm it hydrolyzes in vitro and in vivo to LSD-25. User reports and reagent-testing services indicate the blotters do not trigger Ehrlich or DMAB reagents, necessitating laboratory confirmation.

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Comeup Peak Offset After Effects
    Oral / Sublingual (Blotter Or Liquid) 0.75-2 hrs 30-90 min 3-5 hrs 2-4 hrs 6-24 hrs

    Effect Profile

    4 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 6.5
    Strong 6/10

    Strong visuals and headspace with moderate body load

    Visual Intensity ×3
    8
    color enhancement tracers visual enhancement visual distortions
    Headspace Depth ×3
    8
    conceptual thinking introspection thought loops time distortion
    Auditory Effects ×1
    0
    ⚠ Body Load / Somatic Effects ×1
    6
    vasoconstriction nausea increased heart rate
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 1S-LSD
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use (lysergamide)
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 0h Half tolerance 3d Baseline ~7d

    Rapid tachyphylaxis after one strong session; most effects markedly reduced next day. Approximate return to baseline sensitivity after 7–14 days. Data quality mixed: clinical for LSD itself; inference for 1S‑LSD.

    Cross-Tolerances

    LSD‑25
    90%
    other N1‑acyl lysergamides (1P‑LSD, 1B‑LSD, etc.)
    90%
    psilocin / psilocybin
    70%

    Effects Erowid

    Aggregated from 4 Erowid experience reports

    Positive Effects 7

    Color Enhancement 100.0% 70%
    Music Enhancement 100.0% 70%
    Empathy 75.0% 70%
    Focus Enhancement 75.0% 70%
    Tactile Enhancement 75.0% 70%
    Euphoria 75.0% 70%
    Stimulation 75.0% 70%

    Adverse Effects 2

    Anxiety 75.0% 70%
    Confusion 75.0% 70%

    Combinations TripSit

    1S-LSD's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki