Summary
1S-LSD is 1-(3-trimethylsilyl-propionyl)-LSD, a silicon-containing N1-acyl analogue designed to circumvent Germany's NpSG following the 1D-LSD ban in June 2024. Analytical studies confirm it hydrolyzes in vitro and in vivo to LSD-25. User reports and reagent-testing services indicate the blotters do not trigger Ehrlich or DMAB reagents, necessitating laboratory confirmation. Community consensus suggests oral potency is approximately 70 percent of equimolar LSD-25, with a noticeably slower onset but identical plateau once conversion occurs. Silicon-carbon bonds are hydrolytically labile; moisture-exposed tabs may degrade within weeks.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral / Sublingual (Blotter Or Liquid) | 0.75-2 hrs | 30-90 min | 3-5 hrs | 2-4 hrs | 6-24 hrs |
Tolerance
Build-up
develops rapidly after a single use (lysergamide)
Reset
7–14 days for baseline
Cross-tolerance
Effects
Positive
- Stimulation
- Physical euphoria
Negative
- Vasoconstriction
- Increased heart rate
- Nausea
- Insomnia
- Pupil dilation
- Dilated pupils
- Sedation
- Decreased appetite
Positive
- Euphoria
- Giggling
- Introspection
- Conceptual Thinking
- Wakefulness
- Cognitive euphoria
Negative
- Thought Loops
- Anxiety
- Time Distortion
- Time distortion
Positive
- Visual Enhancement
- Color Enhancement
- Tracers
- Color enhancement
- Increased music appreciation
Negative
- Light sensitivity
- Appetite suppression
- Dehydration
- Geometric Patterns
- Visual distortions