Summary
2-Bromo-4,5-MDMA is an extremely under-researched halogenated MDMA analog with almost no published human data. All dosage and duration information is extrapolated from limited animal pharmacology studies and scarce user reports. In vitro studies suggest markedly reduced SERT (serotonin transporter) affinity compared to MDMA while retaining NET and DAT activity, with modest 5-HT2B agonism. This profile indicates the compound may be less empathogenic and more stimulant-focused than MDMA. Halogen substitution can extend half-life and increase 5-HT2B receptor activation, potentially raising cardiac valvulopathy risk.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 20-60 min | 30-60 min | 1.5-3 hrs | 2-3 hrs | 6-24 hrs |
| Insufflated | 5-15 min | 15-30 min | 1.5-3 hrs | 2-3 hrs | 6-24 hrs |
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute; 1–3 weeks for full reset
Effects
Positive
- Stimulation
- Physical euphoria
- Physical Euphoria
Negative
- Teeth grinding
- Jaw clenching
- Pupil dilation
- Increased perspiration
- Increased heart rate
- Teeth Grinding
- Increased body temperature
Positive
- Cognitive euphoria
- Empathy enhancement
- Sociability enhancement
- Anxiety suppression
- Motivation enhancement
- Wakefulness
- Cognitive Euphoria
Negative
- Anxiety
- Thought acceleration
- Time distortion
Positive
- Tactile enhancement
- Increased music appreciation
- Tactile Enhancement
- Increased Music Appreciation
- Increased libido
Negative
- Disinhibition
- Dehydration
- Appetite suppression
- Light sensitivity
- Spontaneous physical sensations