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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2-Bromo-4,5-MDMA Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 18 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: 6-bromo-mdma, 2-br-4,5-mdma

    Stimulant Research-chemical

    Summary TheDrug.Wiki

    2-Bromo-4,5-MDMA is an extremely under-researched halogenated MDMA analog with almost no published human data. All dosage and duration information is extrapolated from limited animal pharmacology studies and scarce user reports. In vitro studies suggest markedly reduced SERT (serotonin transporter) affinity compared to MDMA while retaining NET and DAT activity, with modest 5-HT2B agonism.

    Dose Information TheDrug.Wiki

    ROA Light Common Strong Heavy
    Oral 40-70mg 70-120mg 120-160mg 160mg+
    Insufflated 20-35mg 35-60mg 60-90mg 90mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset After Effects Total
    Oral 20-60 min 1.5-3 hrs 2-3 hrs 6-24 hrs 5-8 hrs
    Insufflated 5-15 min 1.5-3 hrs 2-3 hrs 6-24 hrs 5-8 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Empathogen 7.3
    Strong+ 7/10

    Strong euphoria, stimulation, and sensory enhancement with mild empathy

    Empathy / Social Openness ×3
    5
    empathy enhancement sociability enhancement
    Euphoria / Mood Elevation ×2
    10
    physical euphoria cognitive euphoria
    Stimulation ×1
    8
    stimulation wakefulness teeth grinding increased heart rate
    Sensory Enhancement ×1
    8
    tactile enhancement increased libido
    Stimulant 5.1
    Moderate+ 5/10

    Strong euphoria and anxiety/jitters with mild stimulation, low focus

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    10
    physical euphoria cognitive euphoria motivation enhancement
    Focus / Productivity ×2
    3
    thought acceleration motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety teeth grinding increased heart rate jaw clenching
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 2-Bromo-4,5-MDMA
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 1d Half tolerance 12d Baseline ~21d

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    • Physical euphoria
    • Physical Euphoria
    Negative
    • Teeth grinding
    • Jaw clenching
    • Pupil dilation
    • Increased perspiration
    • Increased heart rate
    • Teeth Grinding
    Neutral
    • Increased body temperature
    Positive
    • Cognitive euphoria
    • Empathy enhancement
    • Sociability enhancement
    • Anxiety suppression
    • Motivation enhancement
    • Wakefulness
    • Cognitive Euphoria
    Negative
    • Anxiety
    Neutral
    • Thought acceleration
    • Time distortion
    Positive
    • Tactile enhancement
    • Increased music appreciation
    • Tactile Enhancement
    • Increased Music Appreciation
    • Increased libido
    Negative
    • Disinhibition
    • Dehydration
    • Appetite suppression
    • Light sensitivity
    Neutral
    • Spontaneous physical sensations

    Combinations TripSit

    Cross-Check 2-Bromo-4,5-MDMA with another substance

    2-Bromo-4,5-MDMA's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki