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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2-Bromo-4,5-MDMA Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 18 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: 6-bromo-mdma, 2-br-4,5-mdma

    Stimulant Research-chemical

    Summary dose.wiki

    2-Bromo-4,5-MDMA is an extremely under-researched halogenated MDMA analog with almost no published human data. All dosage and duration information is extrapolated from limited animal pharmacology studies and scarce user reports. In vitro studies suggest markedly reduced SERT (serotonin transporter) affinity compared to MDMA while retaining NET and DAT activity, with modest 5-HT2B agonism.

    Dose Information dose.wiki Drugs.Wiki

    Dose basis. Dose ranges are based on sparse user reports and analog reasoning from MDMA; start well below light range when bio-assaying and titrate cautiously with accurate milligram scales. Limited reports; nasal administration produces a faster onset, harsher local irritation, and can encourage redosing—avoid for first trials. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 40-70mg 70-120mg 120-160mg 160mg+
    Insufflated 20-35mg 35-60mg 60-90mg 90mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 20-60 min 30-60 min 1.5-3 hrs 2-3 hrs 6-24 hrs 4.33-8 hrs
    Insufflated 5-15 min 15-30 min 1.5-3 hrs 2-3 hrs 6-24 hrs 3.83-6.75 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Empathogen 5.6
    Strong 6/10

    Moderate stimulation and euphoria with mild empathy and sensory enhancement

    Empathy / Social Openness ×3
    5
    empathy enhancement sociability enhancement
    Euphoria / Mood Elevation ×2
    6
    physical euphoria cognitive euphoria
    Stimulation ×1
    7
    stimulation wakefulness teeth grinding increased heart rate
    Sensory Enhancement ×1
    5
    tactile enhancement increased libido
    Stimulant 4.4
    Moderate 4/10

    Strong anxiety/jitters with moderate euphoria, mild stimulation, low focus

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    7
    physical euphoria cognitive euphoria motivation enhancement
    Focus / Productivity ×2
    3
    thought acceleration motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety teeth grinding increased heart rate jaw clenching
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 2-Bromo-4,5-MDMA there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "2-Bromo-4,5-MDMA (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    2-Bromo-4,5-MDMA
    Unit
    mg
    Description 
    2-Bromo-4,5-MDMA
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 15-25 · light 40-70 · common 70-120 · strong 120-160 · heavy 160+
Insufflated dose (mg): threshold 5-10 · light 20-35 · common 35-60 · strong 60-90 · heavy 90+

Oral duration: onset 0.33-1h · come-up 0.5-1h · peak 1.5-3h · offset 2-3h · total 4.33-8h · after-effects 6-24h
Insufflated duration: onset 5-15m · come-up 15-30m · peak 1.5-3h · offset 2-3h · total 3.83-6.75h · after-effects 6-24h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 95 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 1d Half tolerance 12d Baseline ~21d

    Effects dose.wiki

    Positive
    • Stimulation
    • Physical euphoria
    Negative
    • Teeth grinding
    • Jaw clenching
    • Pupil dilation
    • Increased perspiration
    • Increased heart rate
    Neutral
    • Increased body temperature
    Positive
    • Cognitive euphoria
    • Empathy enhancement
    • Sociability enhancement
    • Anxiety suppression
    • Motivation enhancement
    • Wakefulness
    Negative
    • Anxiety
    Neutral
    • Thought acceleration
    • Time distortion
    Positive
    • Tactile enhancement
    • Increased music appreciation
    • Increased libido
    Negative
    • Disinhibition
    • Dehydration
    • Appetite suppression
    • Light sensitivity
    Neutral
    • Spontaneous physical sensations

    Combinations

    Cross-Check 2-Bromo-4,5-MDMA with another substance

    2-Bromo-4,5-MDMA's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki