2-Bromo-4,5-MDMA
Aliases: 6-bromo-mdma, 2-br-4,5-mdma
Summary
2-Bromo-4,5-MDMA is an extremely under-researched halogenated MDMA analog with almost no published human data. All dosage and duration information is extrapolated from limited animal pharmacology studies and scarce user reports. In vitro studies suggest markedly reduced SERT (serotonin transporter) affinity compared to MDMA while retaining NET and DAT activity, with modest 5-HT2B agonism.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral | 20-60 min | 30-60 min | 1.5-3 hrs | 2-3 hrs |
| Insufflated | 5-15 min | 15-30 min | 1.5-3 hrs | 2-3 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Empathogen
7.3
Strong+
7/10
Strong euphoria, stimulation, and sensory enhancement with mild empathy
Empathy / Social Openness
×3
5
empathy enhancement
sociability enhancement
Euphoria / Mood Elevation
×2
10
physical euphoria
cognitive euphoria
Stimulation
×1
8
stimulation
wakefulness
teeth grinding
increased heart rate
Sensory Enhancement
×1
8
tactile enhancement
increased libido
Stimulant
5.1
Moderate+
5/10
Strong euphoria and anxiety/jitters with mild stimulation, low focus
Stimulation / Energy
×3
5
stimulation
wakefulness
Euphoria / Mood Lift
×2
10
physical euphoria
cognitive euphoria
motivation enhancement
Focus / Productivity
×2
3
thought acceleration
motivation enhancement
Anxiety / Jitters
×1
10
anxiety
teeth grinding
increased heart rate
jaw clenching
Based on reports from:
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute; 1–3 weeks for full reset
Tolerance Decay
Full tolerance
1d
Half tolerance
12d
Baseline
~21d
Effects
Positive
- Stimulation
- Physical euphoria
- Physical Euphoria
Negative
- Teeth grinding
- Jaw clenching
- Pupil dilation
- Increased perspiration
- Increased heart rate
- Teeth Grinding
- Increased body temperature
Positive
- Cognitive euphoria
- Empathy enhancement
- Sociability enhancement
- Anxiety suppression
- Motivation enhancement
- Wakefulness
- Cognitive Euphoria
Negative
- Anxiety
- Thought acceleration
- Time distortion
Positive
- Tactile enhancement
- Increased music appreciation
- Tactile Enhancement
- Increased Music Appreciation
- Increased libido
Negative
- Disinhibition
- Dehydration
- Appetite suppression
- Light sensitivity
- Spontaneous physical sensations
Combinations
2-Bromo-4,5-MDMA's nerd page
Pharmacology, chemical data, effect profiles, and more
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