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    ๐Ÿงช This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2-Me-PiHP

    Aliases: 2-me-alfa-pihp, 2-methyl-alpha-pihp

    Stimulant Research-chemical

    Summary TheDrug.Wiki

    2-Me-PiHP is a 2-methyl analog of ฮฑ-PiHP featuring potent dopamine and norepinephrine transporter inhibition with markedly shortened duration compared to the parent compound, increasing compulsive redosing liability. Vaporized route produces intense crack cocaine-like rush lasting under 30 minutes, driving rapid pipe reloading. Crystalline HCl salt vaporizes around 210ยฐC but generates caustic aerosol causing lung discomfort and transient dyspnea; propylene glycol/glycerin e-liquid (60:40) mitigates irritation but encourages covert dosing.

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Comeup Peak Offset After Effects
    Insufflated 5-10 min 10-20 min 30-90 min 1-3 hrs 4-10 hrs
    Oral 20-40 min 30-60 min 1-3 hrs 2-3 hrs 4-10 hrs
    Vaporized / Smoked 1 min 1-5 min 20-45 min 30-90 min 4-10 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 6.1
    Strong 6/10

    Strong euphoria and anxiety/jitters with moderate focus, mild stimulation

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    10
    physical euphoria euphoria cognitive euphoria motivation enhancement
    Focus / Productivity ×2
    7
    focus enhancement motivation enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    10
    anxiety paranoia teeth grinding increased heart rate vasoconstriction sweating
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 2-Me-PiHP
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3โ€“7 days for acute; 1โ€“3 weeks for full reset

    Tolerance Decay

    Full tolerance 1d Half tolerance 12d Baseline ~21d

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    • Physical euphoria
    Negative
    • Teeth grinding
    • Vasoconstriction
    • Increased heart rate
    • Temperature regulation suppression
    • Insomnia
    • Increased perspiration
    • Increased blood pressure
    • Sweating
    Positive
    • Euphoria
    • Cognitive euphoria
    • Motivation enhancement
    • Focus enhancement
    • Wakefulness
    Negative
    • Compulsive redosing
    • Anxiety
    • Paranoia
    Neutral
    • Thought acceleration
    • Ego inflation
    Positive
    • Increased libido
    • Tactile enhancement
    • Increased music appreciation
    Negative
    • Appetite suppression
    • Dehydration
    • Light sensitivity
    • Disinhibition
    • Appetite Suppression
    Neutral
    • Vibrating vision
    • Increase sexuality

    Combinations TripSit

    2-Me-PiHP's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    ๐Ÿ“˜ Experience Reports ๐Ÿ“– TheDrug.Wiki ๐Ÿ“– PsychonautWiki