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    ๐Ÿงช This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2-Me-PiHP Limited data
    Limited data
    Sparse data. Doses and effects may be unreliable or untested.
    • 1 source
    • duration data present
    • 18 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: 2-me-alfa-pihp, 2-methyl-alpha-pihp

    Summary dose.wiki

    2-Me-PiHP is a 2-methyl analog of ฮฑ-PiHP featuring potent dopamine and norepinephrine transporter inhibition with markedly shortened duration compared to the parent compound, increasing compulsive redosing liability. Vaporized route produces intense crack cocaine-like rush lasting under 30 minutes, driving rapid pipe reloading. Crystalline HCl salt vaporizes around 210ยฐC but generates caustic aerosol causing lung discomfort and transient dyspnea; propylene glycol/glycerin e-liquid (60:40) mitigates irritation but encourages covert dosing.

    Dose Information dose.wiki

    ROA Threshold
    Insufflated 5-10mg
    Oral 10mg
    Vaporized / Smoked 3-5mg

    Only a threshold dose is documented for this substance โ€” the smallest amount with a noticeable effect. There is no published light/common/strong ladder to show above it.

    Onset, Duration & After-effects dose.wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Insufflated 5-10 min 10-20 min 30-90 min 1-3 hrs 4-10 hrs 1.75-5 hrs
    Oral 20-40 min 30-60 min 1-3 hrs 2-3 hrs 4-10 hrs 3.83-7.67 hrs
    Vaporized / Smoked 36 sec 1-5 min 20-45 min 30-90 min 4-10 hrs 0.86-2.34 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 6.1
    Strong 6/10

    Strong euphoria and anxiety/jitters with moderate focus, mild stimulation

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    10
    physical euphoria euphoria cognitive euphoria motivation enhancement
    Focus / Productivity ×2
    7
    focus enhancement motivation enhancement thought acceleration
    Anxiety / Jitters ×1
    10
    anxiety paranoia teeth grinding increased heart rate vasoconstriction sweating

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 2-Me-PiHP there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    Name
    2-Me-PiHP
    Unit
    mg
    Description
    2-Me-PiHP
    Source: SubstanceSearch (substancesearch.com)
    
    Insufflated dose (mg): threshold 5-10
    Oral dose (mg): threshold 10
    Vaporized / Smoked dose (mg): threshold 3-5
    
    Insufflated duration: onset 5-10m ยท come-up 10-20m ยท peak 0.5-1.5h ยท offset 1-3h ยท total 1.75-5h ยท after-effects 4-10h
    Oral duration: onset 20-40m ยท come-up 0.5-1h ยท peak 1-3h ยท offset 2-3h ยท total 3.83-7.67h ยท after-effects 4-10h
    Vaporized / Smoked duration: onset 36s ยท come-up 1-5m ยท peak 20-45m ยท offset 0.5-1.5h ยท total 0.86-2.34h ยท after-effects 4-10h
    
    Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3โ€“7 days for acute; 1โ€“3 weeks for full reset

    Tolerance Decay

    Full tolerance 1d Half tolerance 12d Baseline ~21d

    Effects dose.wiki

    Positive
    • Stimulation
    • Physical euphoria
    Negative
    • Teeth grinding
    • Vasoconstriction
    • Increased heart rate
    • Temperature regulation suppression
    • Insomnia
    • Increased perspiration
    • Increased blood pressure
    • Sweating
    Positive
    • Euphoria
    • Cognitive euphoria
    • Motivation enhancement
    • Focus enhancement
    • Wakefulness
    Negative
    • Compulsive redosing
    • Anxiety
    • Paranoia
    Neutral
    • Thought acceleration
    • Ego inflation
    Positive
    • Increased libido
    • Tactile enhancement
    • Increased music appreciation
    Negative
    • Appetite suppression
    • Dehydration
    • Light sensitivity
    • Disinhibition
    Neutral
    • Vibrating vision
    • Increase sexuality

    Combinations

    Cross-Check 2-Me-PiHP with another substance

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