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    2-MEC Stats & Data

    Ortho-ethcathinone
    NPS DataHub
    MW227.73
    FormulaC12H18ClNO
    IUPAC2-Methylethylcathinone hydrochloride
    SMILES[Cl-].CCNC(C)C(=O)c1ccccc1C.[H+]
    InChIKeySERVJVLEXBDVEE-UHFFFAOYSA-N
    Phenethylamines; Cathinones; 2020/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2021/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2022/1. Von 2-Phenethylamin abgeleitete Verbindungen
    Chemical Class Cathinone
    Psychoactive Class Stimulant
    Half-Life Not established in humans (no reliable PK). Treat as unknown; analog inferences are uncertain.

    Receptor Profile

    Receptor Actions

    Inhibitors
    Dopamine-norepinephrine reuptake inhibitor (NDRI)
    Other
    Serotonin releasing agent (weak)

    Effect Profile

    Curated
    Empathogen 5.7

    Strong sensory enhancement and stimulation with mild empathy, low euphoria

    Empathy / Social Openness×3
    5
    Euphoria / Mood Elevation×2
    3
    Stimulation×1
    9
    Sensory Enhancement×1
    10
    Stimulant 4.9

    Strong anxiety/jitters with moderate focus, mild stimulation and euphoria

    Stimulation / Energy×3
    5
    Euphoria / Mood Lift×2
    5
    Focus / Productivity×2
    7
    Anxiety / Jitters×1
    10

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Not established in humans (no reliable PK). Treat as unknown; analog inferences are uncertain.
    Addiction Potential
    Moderate to high. Cathinones of this class show short duration and strong reinforcement; user forums consistently report ‘fiendish’ redosing with mephedrone and related analogues—risk likely extends to 2‑MEC. Limit session totals and avoid multi‑day binges.

    Tolerance Decay

    Full tolerance 6h Half tolerance 3d Baseline ~10d

    Acute within‑session tachyphylaxis is common with cathinones; repeated redosing produces diminishing returns and a harsher comedown. Cross‑tolerance with other monoaminergic stimulants/empathogens is expected based on mechanism overlap. Waiting at least 7–14 days between sessions reduces residual tolerance and mood after‑effects.

    Cross-Tolerances

    Mephedrone (4‑MMC)
    60% ●○○
    4‑MEC
    70% ●○○
    Other stimulant cathinones
    50% ●○○

    Harm Reduction

    drugs.wiki

    2‑MEC is a positional isomer in the ‘MEC’ family with no formal human pharmacology; dosing and timelines are inferred from closely related cathinones (especially 4‑MEC and 4‑MMC) and should be treated as tentative. Purity and identity are major risks in this market; drug checking services repeatedly find mislabelled or mixed cathinones—do not assume a product sold as ‘MEC’ contains a single compound. Reagent kits have limitations; laboratory GC/MS‑based checking is the gold standard. As with other stimulants/empathogens, hyperthermia and sodium imbalance are key preventable harms: sip electrolytes instead of excess plain water, take cooling breaks, and watch for confusion, headache, or nausea consistent with hyponatraemia. Strong vasoconstriction and tachycardia occur with related cathinones; cold or blue fingertips indicate reduced peripheral blood flow—stop use, rehydrate, warm, and seek care if persistent. Intranasal use increases local vasoconstriction and mucosal injury; alternate nostrils, avoid frequent re‑dosing, and rinse with sterile saline after sessions. Urge‑to‑redose is common; set firm pre‑measured doses and maximum session totals, allow sleep and nutrition, and space sessions by at least 1–2 weeks to reduce mood crash and tolerance. Avoid self‑medicating stimulant side‑effects with random cardio‑active medicines; if chest pain, severe headache, confusion, or overheating occurs, seek emergency medical care—clinicians typically manage severe stimulant toxicity with supportive measures and benzodiazepines.

    References

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