Summary
2-MEC appeared on grey-market outlets around 2012 as a mephedrone substitute, often in 'NRG-2' blends. Studies indicate 2-substituted cathinones are generally weaker than 3- or 4-substituted analogs due to steric hindrance. Users describe it as producing less empathogenic effects compared to mephedrone, with more prominent stimulation and cardiovascular strain. Limited pharmacokinetic data exists; exercise extreme caution with dosing. Multi-gram binges carry serious risks of hyperthermia, hyponatraemia, and severe vasoconstriction.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral / Sublingual | 50-100mg | 100-200mg | 200-350mg | 350mg+ |
| Insufflated | 25-50mg | 50-100mg | 100-250mg | 250mg+ |
| Oral | 50-100mg | 100-200mg | 200-350mg | 350mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral / Sublingual | 15-40 min | 20-40 min | 30-90 min | 1-2 hrs | 2-6 hrs |
| Insufflated | 5-10 min | 10-20 min | 30-90 min | 1-2 hrs | 2-6 hrs |
| Rectal | 10-20 min | 15-30 min | 30-90 min | 1-2 hrs | 2-6 hrs |
| Oral | - | - | 3.0-5.0 hrs | - | 1.0-6.0 hrs |
Tolerance
Build-up
develops rapidly, often within a single session; compulsive redosing common
Reset
a few days for acute tolerance
Effects
Positive
- Stimulation
Negative
- Teeth Grinding
- Jaw Clenching
- Increased Heart Rate
- Vasoconstriction
- Increased heart rate
- Teeth grinding
- Pupil dilation
- Increased perspiration
- Insomnia
Positive
- Euphoria
- Increased Sociability
- Focus Enhancement
- Empathy Enhancement
- Wakefulness
- Motivation enhancement
Negative
- Compulsive Redosing
- Anxiety
- Time distortion
- Thought acceleration
Positive
- Tactile Enhancement
- Tactile enhancement
- Increased libido
- Increased music appreciation
- Color enhancement
- Tracers
Negative
- Light sensitivity
- Dehydration
- Appetite suppression
- Disinhibition